Many changes related to aging at the cellular level may be due to the physiological\ncondition of mitochondria. One of the most common types of damage of mtDNA is the\nso-called ââ?¬Å?common deletionââ?¬Â referring to a deletion of 4977 base pairs. In the skin cells this\nphenomenon probably is caused by oxidative damage of mtDNA induced by UV. The present\nstudy was aimed at evaluating the effect of the antioxidant L-ergothioneine on UV-induced\ndamage in skin cells. The effect of L-ergothioneine on the reduced glutathione level was\nstudied. The presence of the ââ?¬Å?common deletionââ?¬Â in human fibroblasts irradiated with UVA\nand treated with L-ergothioneine was evaluated by a polymerase chain reaction. We have\ndemonstrated that L-ergothioneine enhanced the level of reduced glutathione and protected\ncells from the induction of a photoaging-associated mtDNA ââ?¬Å?common deletionââ?¬Â. In view of\nour results, L-ergothioneine could be an effective skin care and anti-photoaging ingredient.
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