Current Issue : January-March Volume : 2026 Issue Number : 1 Articles : 5 Articles
Obesity is closely associated with appetite dysregulation, influenced by behavioral, hormonal, and neurological factors. The Council on Nutrition Appetite Questionnaire (CNAQ) is a validated tool, translated into Arabic, but its application in weight-loss interventions remains underexplored. This secondary cross-sectional analysis evaluated whether the Arabic CNAQ can differentiate appetite levels after a 6-month telenutrition weight-loss intervention supported by telemonitoring and health coaching, and whether appetite is associated with weight-loss outcomes. A total of 36 participants were assessed: the intervention group (n = 21), who completed the program, and the control group (n = 15), who received no continuous support. Appetite was measured using the CNAQ after 6 months. Independent-samples t-tests and Mann–Whitney U tests were applied to compare appetite scores, while Chi-square tests were used for appetite categories. Results showed mean CNAQ scores of 27.87 (SD = 2.64) for the control group and 26.86 (SD = 4.46) for the intervention group (p = 0.402). Most participants reported moderate appetite (93.3% control; 76.2% intervention), with no significant between-group differences (p = 0.367). Although differences were not statistically significant, the findings demonstrate the feasibility of using the Arabic CNAQ in telehealth weight management. Larger studies with repeated measures are needed to confirm its utility in clinical and dietetic practice....
Psychedelic-assisted therapy offers rapid and profound benefits for treatment-resistant psychiatric conditions but remains constrained by the need for intensive, clinic-based administration. Concurrently, advances in digital health technologies have introduced scalable tools. This systematic review evaluates the safety, efficacy, and implementation of digitally enabled psychedelic-assisted therapy delivered in non-clinical settings. A comprehensive search of five databases, registered in PROSPERO (CRD420251020968) and conducted in accordance with PRISMA guidelines, identified six eligible studies including real-world analyses, clinical trials, qualitative research, and case reports, representing a total of 12,731 participants. Most studies examined at-home ketamine or esketamine therapy supported by telehealth platforms or mobile applications. Data were synthesized narratively given the heterogeneity of designs and outcomes. Digital enablement was associated with high response rates (ranging from 56.4% to 62.8% for depression) and rapid symptom improvement, particularly in depression and anxiety. Remote monitoring and digital tools demonstrated feasibility and acceptability, but serious safety concerns—including psychiatric adverse events and one unintentional overdose—underscore the need for strict oversight. Risk of bias was moderate to serious across non-randomized studies, limiting confidence in the findings. One study on virtual ayahuasca rituals highlighted the sociocultural potential and limitations of online practices. Despite promising preliminary findings, the field is marked by low methodological rigor and absence of controlled trials. Digitally supported at-home psychedelic therapy represents a transformative but high-stakes frontier, requiring robust research and safeguards to ensure safe, equitable, and effective implementation. No funding was received for this review, and the authors declare no conflicts of interest....
Background: Family caregivers of patients with chronic diseases face high levels of burden, anxiety, and burnout, which may negatively affect both their well-being and patient outcomes. Low-cost, accessible telemedicine approaches may provide practical support in resource-limited settings. Methods: We conducted a prospective, parallel-group controlled study in Timisoara, Romania, between April 2024 and March 2025 and included 161 caregivers of older adults with chronic diseases, allocated 1:1 to receive either structured low-cost telemedicine support (weekly phone calls and SMS reminders; n = 82) or usual care (n = 79). Data were collected at baseline, three months, and six months through structured interviews. The primary outcome was caregiver burden measured by the Zarit Burden Interview (ZBI). Secondary outcomes included caregiver anxiety, burnout, satisfaction, and patient-related outcomes such as emergency room (ER) visits, hospital readmissions, and medication adherence. Analyses were performed using ANCOVA and logistic regression, adjusting for baseline values and relevant covariates. Results: At three months, caregivers in the intervention group had significantly lower burden scores compared to controls (adjusted mean difference −2.9; 95% CI −4.7 to −1.1; p = 0.002). Reductions in anxiety (−1.4; p = 0.02) and burnout (−1.6; p = 0.01) were also observed. These effects persisted at six months, though slightly attenuated. Patient outcomes favored the intervention: ER visits were lower at six months (27.50% vs. 41.02%; aOR 0.55, 95% CI 0.30–0.99; p = 0.047), while medication adherence and readmissions showed consistent but non-significant improvements. No adverse effects were reported. Conclusions: A simple, low-tech telemedicine program reduced caregiver burden, anxiety, and burnout and decreased ER visits. Improvements in medication adherence and readmissions were observed, but did not reach statistical significance. This pragmatic intervention can easily be integrated into primary care follow-up or community-based caregiver support programs, providing an affordable and low-cost technique to promote chronic disease management and caregiver well-being, especially in resource-limited health systems....
Volumetric video streaming holds transformative potential for telemedicine, enabling immersive remote consultations, surgical training, and real-time collaborative diagnostics. However, transmitting sensitive patient data (e.g., 3D medical scans, surgeon head/gaze movements) raises critical privacy risks, including exposure of biometric identifiers and protected health information (PHI). To address the above concerns, we propose SecureTeleMed, a dual-track encryption scheme tailored for volumetric video based telemedicine. SecureTeleMed combines viewport obfuscation and region of interest (ROI)-aware frame encryption to protect both patient data and clinician interactions while complying with healthcare privacy regulations (e.g., HIPAA, GDPR). Evaluations show SecureTeleMed reduces privacy leakage by 89% compared to baseline encryption methods, with sub-50 ms latency suitable for real-time telemedicine applications....
Cytoskeleton-associated protein 4 (CKAP4) has emerged as a critical player in gastrointestinal (GI) cancer progression, diagnosis, and therapy. This comprehensive review synthesizes current knowledge on CKAP4s multifaceted roles across GI malignancies, providing novel insights into its mechanisms of action and clinical potential. Its interaction with DKK1 and subsequent activation of the PI3K/AKT pathway underscores its role in promoting tumor growth. This review also highlights novel insights into CKAP4s mechanisms of action beyond the well-established DKK1-CKAP4 axis, including its interaction with integrin β1 and involvement in angiogenesis through the FMNL2/EGFL6/CKAP4/ERK pathway. CKAP4s impact on tumor microenvironment and immune evasion is elucidated, offering a new perspective on its contribution to cancer progression. In addition, CKAP4 arises as a promising serum biomarker for early detection and prognosis across multiple GI cancers, emphasizing its potential superiority over traditional markers. The therapeutic potential of targeting CKAP4 is extensively explored, including novel approaches like anti-CKAP4 antibodies and aptamers, and their synergistic effects with existing treatments. By integrating findings from esophageal, gastric, pancreatic, and colorectal cancers, this review provides a unique, comprehensive overview of CKAP4 in GI oncology, underscoring CKAP4's potential to revolutionize GI cancer diagnosis and treatment and paving the way for future translational research....
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