Current Issue : October-December Volume : 2025 Issue Number : 4 Articles : 3 Articles
The present work aims to establish a simple, precise and rapid spectrophotometric method for quantifying atorvastatin in Active Pharmaceutical Ingredients. In this, work is carried out to estimate atorvastatin bulk by utilizing an Area under Curve (AUC) method using UV – UV-visible spectrophotometry. For this purpose, the wavelength range between 200-400 nm was selected. Distilled water was used as a solvent throughout the work. Linearity was obtained in the concentration range of 2 to 10 µg/ml (r2 =0.997) for the method. The developed method was found to be simple and highly sensitive and can be used for routine quality control analysis for spectrophotometric estimation of Active Pharmaceutical ingredients....
The present work aims to establish a simple spectrophotometric method for quantifying caffeine in active pharmaceutical ingredients. This work was carried out to estimate caffeine bulk by utilizing an area under curve (AUC) method using UV – UV-visible spectrophotometry. For this purpose, the wavelength range between 200-400 nm was selected. Distilled water was used as a solvent throughout the work. Linearity was obtained in the concentration range of 2 to 10 µg/ml (r2 =0.9987) for the method. The developed method was found to be simple, highly sensitive and can be used for routine quality control analysis for spectrophotometric estimation of active pharmaceutical ingredients....
Two simple, sensitive and precise ultraviolet-visible spectrophotometric methods have been developed for the determination of rivaroxaban in pharmaceutical dosage forms. The spectrophotometric detection was carried out at an absorption maximum of 671.5 nm and 559 nm for method A and method B using 3-Methyl-2- benzothiazolinone hydrazone Hydrochloride (MBTH) and Sodium 1,2-naphthoquinone-4-sulfonate (NQS) reagents. The developed methods were validated according to ICH Q2R1 guidelines. The detector response for the rivaroxaban was linear over the concentration range with a correlation coefficient 10 to 50 µg/mL, 0.9993 and 10 to 60 µg/mL, 0.9996 for method A and method B respectively. The percent recoveries were found between 98.8 to 102.73%, indicating that the methods are precise and reproducible. The limit of detection and limit of quantification were found to be 0.008 μg/mL and 0.001 μg/mL and 0.033 μg/mL and 0.026 μg/mL for method A method B respectively. The methods have been successfully employed for the analysis of the marketed formulation of rivaroxaban tablets ‘RIVALTO’ by Synokem Pharmaceuticals Ltd. and the percentage purity was found to be 99.76% for both methods. The proposed methods can be successfully employed for the routine analysis of rivaroxaban in quality control laboratories....
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