Inventi Rapid: Novel Excipients

Inventi:prne/113440/25

Preformulation and Compatibility Study of Nifedipine Drugs with their Excipients

The objective of the present research work was preformulation study, evaluating physicochemical compatibility between synthetic drugs and herbal excipients. Nifedipine drug were selected as model drug where as tamrind seed gum (TSG) and fenugreek seed gum (FSG) were used as excipients. Preformulation studies were performed using Ultra Violet spectroscopy (UV) and Higher Performance Liquid Chromatography (HPLC). Then after drug and excipients compatibility studies were checked by Fourier transform infrared spectroscopy (FTIR), Different Scanning Colorimetric study (DSC) and Thin layer chromatography (TLC). The spectrophotometric graphs showed that there was no significant alteration occurred in position of functional groups in pure drugs and their herbal excipients with respect to their physical mixtures. DSC study represented that the characteristic peaks of drug appeared which showing that drug and their excipients was present as a crystalline form as well. The Rf values of the physical mixtures obtained from TLC study on the 0th and 30th day were approximately similar to the Rf values of the pure drug and herbal excipients. All of the experimental results and retention factor clearly validated that the synthetic-herbal drug combinations with pharmaceutical excipients are compatible with each other and can be utilized for successful development of different dosage formulations....