Current Issue : April-June Volume : 2025 Issue Number : 2 Articles : 1 Articles
In recent years, significant advancements have been made in drug delivery systems, particularly through the use of innovative microparticulate carriers such as microemulsions, nanoemulsions, nanoparticles, liposomes and ethosomes. These systems have been extensively studied for their ability to enhance the delivery of both hydrophilic and hydrophobic drugs, improving therapeutic efficacy. Liposomes, which are phospholipid-based vesicles that self-assemble into bilayers, have emerged as a promising drug delivery system. Their ability to encapsulate active agents within a central aqueous compartment makes them suitable for targeted drug delivery. In this study, rabeprazole sodium, a BCS Class III drug, was encapsulated into liposomes to improve its bioavailability and efficacy in treating gastroesophageal reflux disease (GERD). Rabeprazole sodium, being hydrophilic, presents challenges in absorption, which makes liposomal delivery a valuable approach for enhancing its therapeutic potential. The formulation process was guided by Design Expert software, utilizing a 2² central composite design to optimize the formulation. A total of 13 experimental runs were conducted, which allowed for the identification of an optimized liposomal formulation. This optimized formulation offers a promising strategy for improving drug delivery, targeting and bioavailability, which could lead to more effective treatment of GERD. This research underscores the potential of liposomal drug delivery systems in enhancing the treatment of GERD and highlights the importance of design software in optimizing pharmaceutical formulations for improved clinical outcomes....
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