Frequency: Quarterly E- ISSN: 0976-3791 P- ISSN: IBI Factor: 4, H-Index: 1, RI Factor 2.24, Global Impact Factor 0.76 (2015) Abstracted/ Indexed in: CAS database (a division of the American Chemical Society), Ulrich's International Periodical Directory, Google Scholar, SCIRUS, Genamics Journal Seek, PSOAR, getCITED, InfoBase Index, EBSCO Information Services
Quarterly published in print and online "Inventi Rapid: NDDS" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under novel drug delivery systems. It welcomes articles pertaining to nano drug delivery systems; gastroretensive system, colonic drug delivery, bioadhesive and mucoadhesive systems; nasopulmonary drug delivery; ocular delivery; transdermal delivery, implants and inserts; protein and peptide delivery; manufacturing, quality control and regulatory aspects of NDDS, etc.
Self-emulsifying drug delivery systems (SEDDS) are mixtures of oils, surfactants and co-surfactants, which improve dissolution of poorly soluble drugs by rapid self-emulsification. It is estimated that about 40% of active pharmaceutical substances are poorly water soluble. Various strategies are reported including micronization, solid dispersions, complexation and other technologies. Among various approach SEDDS has gained an important attention due to enhanced oral bioavailability, more consistent temporal profiles of drug absorption, targeting of drugs toward specific absorption window and protection of drug from the hostile environment in gut. The important characterization parameters are their globule size and shape, ability to encapsulate the drug, gastrointestinal and thermodynamic stability and rheological characteristics. This review highlights an explicit discussion on important applications of the SEDDS and other important relevant information....
Manuscript removed on reviewer/editorial board recommendation...
Fast dissolving tablets are well established dosage forms available in the market. These are novel types of tablets that disintegrate/dissolve/ disperse in saliva within few seconds. The numerous advantages that they offer to the patients in terms of compliance as well as to the manufacturers in terms of huge revenues by line extension of products are well known. In spite of such popularity, there seems to be lack of a standardized system to characterize these dosage forms. This review article attempts to present a various technology for preparation and patented technology of this novel type of dosage form along with the advances made so far in the area of evaluation with respect to special characteristics of these unique dosage forms....
The Parenteral administration route is the most effective and common form of delivery for active drug substances with poor bio-availability and the drugs with a narrow therapeutic index. Though parenteral administration of drug is often critical and associated with problems such as limited number of acceptable excipients, stringent requirements of aseptic production process, safety issues and patient non-compliance. Still this route maintains its value due to special advantages like quicker onset of action in case of emergency, target the drug quickly to desired site of action, prevention of first pass metabolism etc. The Atrigel system is a proprietary delivery system that can be used for both parenteral and site-specific drug delivery. It consists of biodegradable polymers dissolved in a biocompatible carrier. When the liquid polymer system is placed in the body using standard needles and syringes, it solidifies upon contact with aqueous body fluids to form a solid implant. The ease of manufacture of the Atrigel system and its relatively pain-free subcutaneous injection into the body provide significant advantages over both solid implants and microparticles. Atrigel technology was licensed to the Atrix Laboratories. Atrigel technology currently used in cancer therapy, periodontal treatment and delivery of protein and peptide drugs. By using this technology we can delivered anaesthetics, antibiotics, vaccines, antipsychotics, hormones and NSAIDS in future. This review article complies the information on the in-situ gel forming system i.e. Atrigel technology designed to provide a more stable, ready-to-use formulation to provide drug release in sustained manner....
Multiparticulate dosage forms are receiving a great deal of attention as alternative system for oral drug delivery. The present review outlines the theory behind the pellet formation, its growth mechanism, its purposes and advantages. The techniques namely extrusion-spheronization, the most widely used pelletization technique in the pharmaceutical industry as it is a robust, simple, fast processing and reproducible pellet production process, have been described along with parameters affecting pelletization. Extrusion spheronization is widely utilized in formulation of immediate release, sustained release and controlled release delivery systems. Evaluation of the pellets is discussed with reference to the size distribution, shape, surface morphology, specific surface area, friability, tensile strength, density, porosity, disintegration time and in vitro dissolution studies of pellets. This review focuses on the extrusion-spheronization techniques of pelletization with its merits, process mechanisms, process variables and pellets characterization, as a tool in the multiparticulate drug delivery system....
The purpose of writing this review on gas powered systems (GPS) was to compile the recent literature with special focus on the principal mechanism of floatation to achieve gastric retention. The recent developments of Gas Powered System (GPS) including the physiological and formulation variables affecting gastric retention, approaches to design single-unit and multiple-unit floating systems, and their classification and formulation aspects are covered in detail. Drugs with narrow absorption window in the gastrointestinal tract have poor absorption. Therefore the gas powered system have been developed, which prolong the gastric empting time. The improved controlled drug delivery system of the present invention is designed to deliver effectively a drug to a patient over a specific time period (temporal control) and from particular portion of the patients gastrointestinal tract (spatial control).the improved controlled drug delivery system avoids dose dumping and results in the most therapeutic administration of a particular drug to a particular person with a particular ailment to improved the bioavaibility. These systems are useful to several problems encountered during the development of a pharmaceutical dosage form....
Hydrogels are crosslinked polymeric networks, which have the ability to hold water within the spaces available among the polymeric chains. Hydrogels have been gaining significant importance due to their potential uses in cell based therapies, tissue engineering, liquid micro-lenses, cancer therapy, cell carriers and/or entrapment, wound management and drug delivery. They are sensitive to environmental stimulus like aqueous media, pH, temperature, glucose concentration, electric field, light, etc. A number of synthetic hydrogels such as poly (N-isopropylacrylamide) (pNIPAm), polyethylene glycol (PEG), polyvinyl alcohol methylacrylate co-polymers (PVA-MA) and polylactic acid (PLA), as well as some of the natural hydrogels such as Fibrin, Hyaluronic acid (HA), Agarose, Alginate and chitosan are available. Because of the compatibility with living tissues, hydrogels can be used in different medical purposes (for making contact lenses, stents, balloon catheters, artificial muscles, substitutes for arteries and veins, trachea, oviduct, for neutraceutical delivery, regenerative medicine). Self-healing materials are of great importance as they offer longer lifetime, low replacement cost and greater product safety and can be used in any stress-bearing applications. The biocompatibility of hydrogel and its ability to response to environmental stimuli make it an attractive candidate for many biological and engineering applications....
The controlled release of drugs in slow and sustained manner is one of the major challenges in drug delivery system. Targeting of drug to the particular site is an important aspect of drug delivery system. This delivery system also used for lipophilic drug which are soluble in intestine. Microparticles were initially developed as carrier for vaccines & anticancer drugs. They have now been used to increase the efficiency of drug delivery system & improve release profile & for drug targeting. These delivery systems offer numerous advantages compared to conventional dosage forms, which include improved efficacy, reduced toxicity, improved patient compliance and convenience Microparticles have been proven to be useful in this manner for the delivery of various active pharmaceutical ingredients. The current aim of this review is to study various aspects of the microparticulate drug delivery system including method of formulation, evaluation & characterization....
Despite phenomenal advances in the injectable, inhalable, transdermal, nasal and other delivery systems, the oral route is still considered the most preferable for both patients and industry. Being natural, noninvasive and safe method of drug delivery, oral delivery is, always, associated with high degree of patient compliance. On the other hand, oral delivery systems are able to accommodate various physicochemical properties of drugs, do not require strict sterile conditions and therefore less expensive to manufacture. Thus, even small improvements in oral drug delivery technology can make significant difference in enhancing patient compliance and drug delivery fields in general. Over the past decades, several novel technologies for oral delivery have been developed, examples include; oral rapid disintegrating (dissolving) tablets, mucoadhesive buccal dosage forms, site specific drug delivery and novel controlled release dosage forms. The review describes the various formulation aspects, superdisintegrants employed and technologies developed for MDTs, along with various excipients, evaluation tests, marketed formulation and drugs used in this research area....
The concept of research subscribed in this article is directed towards the development of some NDDS for the treatment of various life threatening diseases and disorders. The nanosuspension can be proved as a gift as the poorly water soluble drugs can be easily formulated into nanosuspension. One of the critical problems associated with poorly soluble drugs is too low bioavailability. There are number of formulation approaches to resolve the problems of low solubility and low bioavailability. Nanosuspension not only solves the problems of poor solubility and bioavailability but also alters the pharmacokinetics of drug and thus improves drug safety and efficacy. Nanosuspensions are sub-micron colloidal dispersions of nanosized drug particles stabilized by surfactants....
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