Frequency: Quarterly E- ISSN: 0976-3813 P- ISSN: Global Impact Factor- 0.42, IBI Factor: 4.09 Abstracted/ Indexed in: CAS database (a division of the American Chemical Society), Ulrich's International Periodical Directory, Google Scholar, SCIRUS, Genamics Journal Seek, PSOAR, getCITED, JOURNAL directory, InfoBase Index, EBSCO Information Services
Quarterly published in print and online "Inventi Rapid: Pharm Analysis & Quality Assurance" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas under pharmaceutical analysis and quality assurance. It welcomes articles pertaining to qualitative and quantitative analysis of drugs, excipients, and impurities etc. to meet the regulatory requirements; analysis of modern and traditional medicines; quality control methods for biological drugs; quantitative and qualitative analysis in the drug screening processes; tracer analysis in molecular pharmacology; clinical and biological analysis, etc.
Formulating the 12 principles of Green Analytical Chemistry (GAC), by modification of the Green principles made them more applicable towards Analytical chemistry. These principles hold importance in designing of new methods or instruments. The focus of greening a chemical method is by generating solvent-less techniques or using alternative solvents like ionic liquids. Miniaturization of separation techniques employing FAC instruments would be another approach to reduce solvent consumption and production of analytical wastes. Capillary electrophoresis was rather unknown for its use as an alternative in place of GC, until recently. Owing its wide application and use, greening chromatographic methods like HPLC, GC is the upcoming trend. Various newer techniques complying with the principles of GAC are a safer option over conventional non-green methods for analysis. The article is primarily an overview covering the introduction and development of green methods in analytical chemistry....
Improvement of life quality is the major important objectives of the global research work. The quality of life is related to a better control of diseases, the quality of our environment and drug and food quality and safety. A continuous, fast, reliable and sensitive monitoring is required to control key parameters and biosensors are very much important for that purpose. Biosensors are composed of two main parts such as a biological recognizing component (enzyme, antibody, cell and tissue) which is connected to a physical transducer (spectro¬photometric, conductometric, voltammetric and amperometric). Various biological systems that can be used as recognizing agents allow specific biosensors for many analytes. Biosensors mainly used due to high sensitivity, specificity, ease of use, fast, cost-effective and repetitive measurements with miniaturized and portable devices for the quality analysis of drugs, medicines and other analytes of interest in the pharmaceutical, biomedical and environmental field. Biosensors allow quantification of the active component in pharmaceutical formulations and also the degradation products and metabolites analysis in biological fluids. Thus, this work presents a brief review of biosensor application in pharmaceutical analysis....
Acorus calamus is a valued drug used extensively in Ayurvedic therapeutics. Due to high market demand, Acorus is being cultivated. Hence the study was undertaken to analyze the morphological and chemical characteristics of Acorus calamus Linn. especially β-asarone collected from its cultivated as well as wild sites and demonstrate any similarities seen. The results of the study indicated that there is no much difference in the morphological features and phyto chemical parameters. GC-MS revealed β-asarone was moderately high in wild variety (85.34%) compared to cultivated one (78.49 %) which could be attributed to environmental factors. Pharmacological study is desirable for greater comparability of the results obtained to assure the usage of cultivated variety....
Nelfinavir (NFV) is an antiretroviral drug used in the treatment of the human immunodeficiency virus. NFV is available alone in dosage form as well as multicomponent formulation with various antiretroviral drugs like ritonavir, saquinavir, darunavir, atazanavir, nerverapine and lopinavir for the systematic management of HIV. The present review explores to assess the various approaches for analysis of NFV in bulk drug as well as formulated products. This review represents the compilation and discussion of about more than 25 analytical methods which includes HPLC, LCMS, HPTLC, Capillary electrophoresis, electrochemical and UV Spectrophotometry methods implemented for investigation of NFV in biological matrices bulk samples and in different dosage formulations....
Atazanavir sulfate act as a protease inhibitor for the treatment HIV infection. Drug is of crucial importance to treatment and related research all over the world. So it is great interest of study to overview the analytical profile of ATV alone and in combination. The significant work is already reported for estimation of ATV. The privilege applicability of ATV was found by HPLC method and subsequently UV method. Very less literature was reported by UPLC and HPTLC methods. The ATV found in combination with ritonavir and cobicistat which are mostly used. The present article attempt to review many existing methodologies and the instrumental conditions that were applied in the last decade to quantify ATV and its metabolites. The authors have made special efforts to gather and compile the brand names of ATV alone and in combination. Such knowledge will assist in the development of new delivery systems in pharmaceutical research. The investigation will be useful and beneficial pre-formulation research and further analytical study of ATV....
Entacapone is a particular, reversible catechol methyl transferase (COMT) inhibitor for the treatment of Parkinson's ailment entacapone is a selective and reversible inhibitor of catechol ortho methyltransferase (COMT), with essentially fringe actions. It is utilized in the treatment of Parkinson's malady as an extra to levodopa/carbidopa treatment. So it is extraordinary enthusiasm of study to outlines the investigative profile of ETP alone and in mix. The benefit relevance of ETP was found by HPLC technique and in this manner UV strategy. Less writing was accounted for by UPLC and LC MS-MS strategies. Such estimations consistently need exact pharmacological and physicochemical data; subsequently creators have introduced it in advance. The article further presents a concurrent and similar appraisal of the diagnostic investigations referencing pharmaceutical estimation of medication to aid current examination. The careful writing look through uncovered twenty five research papers altogether till date. Such information will aid the advancement of new conveyance frameworks in pharmaceutical research....
Paroxetine (PAX) is a powerful and selective serotonin reuptake inhibitor (SSRI) with some neuropharmacological properties used mainly for the treatment of anxiety and depression. Due to the first pass degradation, PAX suffers poor bioavailability issues and this limits its clinical application. In context to this, the present review focuses the various formulations related with transdermal liposomes, nano emulsion via olfactory region and brain targeted intranasal in-situ gelling spray for the management of depression. Additionally, we also discuss about the various analytical methods such as HPLC, HPTLC, UV, LC-MS/MS, GC-MS which are reliable and sensitive for the quantification of PAX in different pharmaceutical dosage forms. This concise review presents the survey of physiochemical properties, transdermal as well as intranasal drug delivery systems and analytical methods used for PAX determination, being carried out through scientific journals as well as official compendia....
RP-HPLC is the most powerful and dominant analytical technique available in todays world of pharmaceutical analysis. This review presented a step-by-step approach to RP-HPLC method development and its validation. Method development, validation and its life cycle management must incorporate in it the concept of QbD and QRM. Exhaustive chromatographic literature review and collecting maximum information on sample is very first prerequisite of method development. It further requires performing various experiments with sound judgement on selection of chromatographic conditions like mobile phase, stationary phase, column temperature, flow rate, detector and detection wavelength, injection volume, etc for method optimization. Further to fasten and simplify the development work latest automated method scouting techniques can be used. Gradient scouting is a powerful technique to screen between isocratic or gradient method. Validation of analytical procedure requires addressing various validation characteristics like accuracy, precision, specificity, linearity, range, LOD, LOQ, robustness. Statistical analysis of validation data shall be used to evaluate validation characteristics against predetermined acceptance criteria. Once the validation is successful the analytical method could be transferred to laboratories for routine application....
A simple, specific, accurate and economical uv-spectrophotometric method has been developed for estimation of niacin from bulk and pharmaceutical formulation. The solvent used to develop the method was methanol. The λ max of niacin in methanol was found to be 260 nm. The drug follows linearity in the concentration range of 2-10 µg/ml with correlation coefficient value 0.999. The proposed method was applied to pharmaceutical formulation and % amount of drug estimated 99.99% was found in good agreement with the label claim. The accuracy of the method was checked by recovery experiment performed at three different levels i.e. 25%, 50% and 100%.The % recovery was found to be in the range 98.88%-99.99%. The low values of % R.S.D are indicative of the accuracy and reproducibility of the method. The precision of the method was studied as an intra-day, inter-day variations and repeatability. The % R.S.D value less than 2 indicate that the method is precise. The above method was a rapid and cost-effective quality-control tool for routine analysis of niacin in bulk and in pharmaceutical dosage form....
A simple, rapid, specific, accurate and precise reverse phase high performance liquid chromatographic method was developed for the estimation of Ilaorazole in Tablet dosage form. C18 (hypersil column) 5mm column having 250Ã?â??4.6 mm id in Isocratic mode with mobile phase containing orthophosphoric acid: methanol (70:30) was used. The flow rate was 1 ml/min and effluents were monitored at 226 nm. The retention time of Ilaprazole is 4.1. The calibration curve was linear over a concentration range from 10 Ã?µg/ml-30 Ã?µg/ml for Ilaprazole.Limit of detection (LOD) and Limit of quantitation (LOQ) were 0.05865 Ã?µg/ml and 0.195503 Ã?µg/ml for Ilaprazole respectively. The developed method was fast, accurate, precise and successfully applied to estimate the amount of Ilaprazole in bulk sample and tablet dosage form so it can be used for regular quality control of the drug....
Loading....