Frequency: Quarterly E- ISSN: 0976-3848 P- ISSN: IBI Factor: 4.09 Abstracted/ Indexed in: Ulrich's International Periodical Directory, Google Scholar, SCIRUS, Genamics Journal Seek, PSOAR, getCITED, InfoBase Index, EBSCO Information Services
Quarterly published in print and online "Inventi Rapid: Pharmacy Practice" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. This journal focuses on discipline of pharmacy which involves developing the professional roles of pharmacists. The scope of the journal includes clinical pharmacy, hospital pharmacy, community pharmacy, pharmaceutical care, pharmacovigilance, social pharmacy, pharmacy education, process and outcome research, health promotion and education, health informatics, pharmacoeconomics and other related areas.
World Health Organization defines pharmacovigilance as the science and activities relating to the detection, assessment, understanding and prevention of adverse effects or any other medicine-related problems. In an effort to strengthen the pharmacovigilance in India, government has initiated pharmacovigilance programme of India. Spontaneous reporting of adverse drug reaction is globally practiced it under pharmacovigilance programme. But the major drawback of this system is underreporting. In this context the present survey was conducted, to assess the knowledge, attitude and practice of spontaneous ADR reporting among doctors in a tertiary care teaching hospital in South India. A cross-sectional questionnaire-based survey was conducted among doctors in a tertiary care teaching hospital in South India. The completed questionnaire information was recorded using Microsoft Excel spreadsheet (Microsoft Office 2007). The data was analyzed simple ratios, proportions, Chi-square tests were ever needed. In this study 60% of study subjects have awareness regarding pharmacovigilance, 65% have ADR reporting is a professional obligation, 73% knows about existence of pharmacovigilance programme in India. 95% felt that reporting of adverse drug reaction is necessary, 92% subjects say pharmacovigilance should be taught to health care professionals, 75% subjects opinion is that ADR monitoring center should be established in every hospital. 6% experienced adverse drug reactions in their patients only 20% reported ADR only 40% are trained on how to report ADR. The findings of the study suggest a huge scope for improving the awareness and knowledge about pharmacovigilance among the undergraduate students and health care professionals. Regular training on basic principles of pharmacovigilance and ADR reporting, easy accessibility ADR reporting forms, establishing a network of doctors for ADR reporting. For this, there is a need for continuous educational initiatives like CME and it should also be included in their curriculum as part of their study....
Around 20% of neurologists in the America were not aware of antiepileptic safety risks in patients of Asian descent. Carbamazepine (CBZ) remaining the first line therapy for trigeminal neuralgia, is causative for ADRs ranging from mild maculopapular exanthema to life threatening severe reactions, including SJS, an immune complex mediated hypersensitivity reaction that involving mucous membranes and the skin. At extreme ages, due to decreased immunity Stevens-Johnson syndrome is reported mostly. Patients with viral infections seem to have a higher risk of acquiring Stevens-Johnson syndrome. Antiepileptics, antibiotics and anticonvulsants are mostly reported to be implicated in Stevens-Johnson syndrome. Drugs with longer half-life were reported to cause adverse reactions more than those of with shorter half-life. Enzymes responsible for bioactivation and detoxification of Carbamazepine and their potential defects were proposed as possible mechanism for Stevens-Johnson syndrome. Fluid and electrolyte imbalances, moderate leukocytosis, elevated liver transaminase, microalbuminuria, hypoproteinuria, hyponatremia, and anaemia are known symptoms of Stevens-Johnson syndrome. ALDENS algorithm is specific method for diagnosis Stevens-Johnson Syndrome. The Food and Drug Administration in the United States, in 2007 recommended genetic testing of HLA-B*1502 allele in patients with ancestry across areas of Asia before prescribing Carbamazepine. Corticosteroids and intravenous immunoglobulins are immediate treatment options of Steven-Johnson syndrome. In United States, the average annual incidence of SJS was estimated to be around 1.2 to 6 cases per million with a male to female ratio of 1.5:1....
Major depressive disorder (MDD) is a common psychiatric disorder, which is emerging mental disorder in most of the population. Imbalance in serotonin and norepinephrine neurotransmitters is thought to be the major cause of depressive disorder. Pharmacological management of MDD include first generation anti depressants such as Tri Cyclic Antidepressants (TCAs), Mono Amine Oxidase Inhibitors (MAOIs), and second generation antidepressants include Selective Serotonin Reuptake inhibitors (SSRIs) and Selective Norepinephrine Reuptake inhibitors (SNRIs). In the year 2013 Food and Drug Administration (FDA) approved two drugs for the treatment of MDD, namely levomilnacipran and vortioxetine....
Anticonvulsants are the medications used in the treatment of epileptic conditions. There are various categories of anticonvulsant which includes hydantoins, barbiturates, benzodiazepines. Their use is also extended to treat bipolar disorders, borderline personality disorders as many are used in mood stabilization and reducing neuropathic pain. These drugs are known to cause various adverse effects depending on dose. Antiepileptic drugs not only cause adverse effects related to central nervous system but also cause cutaneous symptoms. Some of the cutaneous adverse symptoms related to antiepileptic medications are toxic epidermal necrolysis, Stevens-Johnson syndrome, acute generalized exanthematous pustulosis, drug induced hypersensitivity syndrome (DIHS), drug reaction with eosinophilia and systemic symptoms (DRESS). In this, we report about a patient presented with hyper pigmented scaly plaques on administration of phenytoin....
The report presents a case of adverse drug reaction induced by moxifloxacin eye drops in a 26-year-old male patient who self-administered the medication for eye itching. The patient developed swelling of the eyelid and redness of the eye, which were identified as hypersensitivity reactions to the drug. The adverse event was managed by discontinuing the eye drops and providing supportive therapy, leading to the patient's recovery. The Naranjo ADR probability scale categorized this reaction as a probable adverse drug reaction with major severity. The study highlights the importance of considering a patient's medical history, allergies and potential drug interactions when prescribing moxifloxacin eye drops. Healthcare professionals should be vigilant for adverse reactions such as irritation, burning, or blurred vision and promptly address any such events to ensure patient safety. This case report underscores the significance of monitoring for adverse drug reactions and providing appropriate management to optimize patient outcomes....
Pantoprazole is the drug of proton pump inhibitor class. It is used for the treatment of stomach ulcers, short-term treatment of heartburn, gastroesophageal reflux disease. An ADR report related to a patient he developed vitamin B12 deficiency while being treated with pantoprazole. The patient, who had been treated with pantoprazole 20 mg BD for stomach upset, vomiting (G.I disturbance). After the treatment of 1 month the patient started weakness, pale skin, tingling in hands, dizziness and fatigue. The patient consulted his physician who is a gastroenterologist. After a thorough examination the physician asked to patient for blood tests which revealed that the Hb is normal but the amount of Vit. B12 present in the blood is less than the normal. It was confirmed that, after the use of pantoprazole Vit. B12 blood levels have decreased which lead to the sign and symptoms. This case report summarizes that on long term use of pantoprazole should be supported by supplemental therapy with Vit. B12....
Phytophotodermatitis is a non-immunological cutaneous phototoxic inflammatory eruption resulting from contact with light sensitizing botanical substances and long wave UV-A radiation. Mainly signs and symptoms include blister like patches that are itchy and irregular in shape. The most commonly affected areas are legs, hands, arms, face. This condition is mainly treated with antihistamines, corticosteroids and cold compress. Our patient with this condition was apparently normal 15 days back. In our patient diagnosis was confirmed by taking history and physical examination. This was treated with saline compress, Tab. Prednisolone 40 mg, Tab. cetrizine 10 mg once daily for one month and then follow up was done for 6 months. Along with the treatment, counseling should be provided to patient and also family members on exposure to plants....
Hypokalemia is one of the most commonly seen electrolyte imbalance in the clinical settings in which the serum potassium levels are less than 3.5 mEq/L (normal range: 3.5 to 5 mEq/L). Hypokalemia usually occurs in conditions such as renal tubular acidosis, villous adenoma of colon, hypomagnesemia, Zollinger Ellison syndrome, cardiovascular disorders, cancer, poisoning and often drug induced. Hypokalemia can be caused by the diuretics, antimicrobials, laxatives, beta 2 receptor agonists, high dose of insulin, xanthines over dose of verapamil, glucocorticoids and mineralocorticoids. In this case report we discussed regarding the management of prednisolone induced hypokalemia condition in a 40 year old female patient who was under the treatment for Pemphigus Vulgaris in the department of dermatology. Hypokalemia is occasionally confronted adverse reaction in the clinical setting where physicians and clinical pharmacists should be attentive while treating the patients. Early diagnosis and treatment may avoid the life threatening complications. As most of the hypokalemia incidences are drug induced, clinical pharmacists who monitor the patient’s drug therapy should be cautious in finding out the etiology of hypokalemia thereby aiding the patient wellness by decreasing the hospital stay and economic burden of the patient....
It is a cosmopolitan disease due to the embryonic shape of Taenia of the dog echinococcosis granulose. It is the disease which puts a real problem of public health in our country. We reported a case of hydatid cyst of the liver in a 32-year-old man who originally lived in India and had migrated to Andhra Pradesh 2 years earlier. He presented with right upper quadrant pain and intermittent low-grade fever. Both sonography and computed tomography (CT) demonstrated a cystic lesion with vesicles at its periphery in segments 6 and 7 of the liver. A hydatid cyst was diagnosed. The patient underwent radical excision of the cyst with total removal without opening the wall. He also received pre- and postoperative oral mebendazole. Pathology showed a hydatid cyst consisting of three layers: the inner single nucleated geminal layer, the middle acellular laminated layer and the outer pericyst originating from inflammatory and hepatic cells. This case highlights that accurate preoperative diagnosis of hydatid disease can be made from personal history; typical sonography and CT study in non-endemic areas. A laparoscopic approach is safe in some situations. Percutaneous drainage with albendazole therapy is a safe and effective alternative treatment for hydatid cysts of the liver. Radical surgery with pre- and post-operative administration of albendazole is the best treatment option for liver hydatid cysts due to low recurrence and complication rates....
The resistance among innumerable microbial species to various antimicrobial drugs has materialized as a cause of public health hazard all over the world at an alarming rate. Even though the development of multi drug resistant infection is a natural phenomenon, the incongruous use of antimicrobial drugs, inadequate sanitary conditions, irrational usage of antibiotics and underprivileged infection prevention and control practices contribute to emergence of multi drug resistant infection. Here we presented a case on multidrug resistant infection, which seems to be a challenge for antibiotics. So the objective is to create awareness regarding resistance and rational use of antibiotics to prevent multi drug resistant conditions....
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