Frequency: Quarterly E- ISSN: 0976-3856 P- ISSN: IBI Factor: 4.1 Abstracted/ Indexed in: Ulrich's International Periodical Directory, Google Scholar, SCIRUS, Genamics Journal Seek, PSOAR, getCITED, JOURNAL directory, InfoBase Index, EBSCO Information Services
Quarterly published in print and online "Inventi Rapid: Molecular Pharmacology" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas in the growing field of molecular pharmacology. It aims to cover the developments in cellular and molecular pharmacology with a major emphasis on the mechanism of action of drugs under development, innovative pharmacological technologies, cell signaling, transduction pathway analysis, genomics, and proteomics.
Cardiac biomarkers play a crucial role in accurate diagnosis of myocardial necrosis and for assessing risk and directing appropriate therapy that improves clinical outcome. The use of biomarkers in basic and clinical research as well as in clinical practice has become so common. The earliest biomarkers such as alanine aminotransferase and lactate dehydrogenase have fallen out of use with the development of more sensitive and specific cardiac biomarkers like creatine kinase isoenzyme MB and cardiac troponin. Myoglobin must be considered a biomarker that may lack sensitivity for the diagnosis of MI but appears to have value for risk stratification. The major classes of biomarkers are biomarkers of necrosis, biomarkers of inflammation and biomarkers of hemodynamic stress. The discovery of novel and tissue-specific cardiac biomarkers is important to early detect and prevent cardiac damage....
Most of the women take either prescribed or over-the-counter medication during pregnancy. Pregnant women often make independent decisions about their treatment and require careful counseling that allows them to balance the risk of taking a drug against the risk of not taking a drug and leaving a medical condition untreated. Most drugs are safe in pregnancy but some have unproven safety and may adversely affect the growing fetus. The safety profile of some of the medication may change according to the gestational age of the fetus. An estimated 10% or more of the birth defects results from maternal drug exposure. The development of knowledge in understanding the use of drugs during pregnancy has been in stalemate in comparison to other areas of therapeutics, mainly due to difficulties in testing new products in pregnant women and paucity of good quality research....
Phenolics are the large classes of compounds, spread extensively in plant kingdom, especially the secondary metabolites like simple phenol and phenolic acids. Article was designed to explore the therapeutic effect of quinic acid through available literature (last 20 years literature). The last 20 years literatures was carried out by searching bibliographic data bases such as Pubmed, Scopus, Google scholar and web of science. The data were collected by keywords like “Quinic Acid” and “Pharmacological activity” without narrowing or limiting search items. Publications with abstracts were reviewed only. Total publications found in initial research were 80, in which 37 publications were considered for study and remaining were excluded because of its specificity to the subject. This article will provide all the information of quinic acid like description, physical properties, pharmacokinetics and pharmacodynamics studies, molecular mechanism and its scope for future work....
Rheumatoid arthritis is a chronic, systemic inflammatory disorder that may affect many tissues and organs, but principally attacks synovial joints. About 1% of the world's population is afflicted by rheumatoid arthritis, women three times more often than men. The exact causes of rheumatoid arthritis are unknown. Rheumatoid arthritis is most likely triggered by a combination of factors, including an abnormal autoimmune response, genetic susceptibility, and some environmental or biologic trigger, such as a viral infection or hormonal changes. The process produces an inflammatory response of the synovium (synovitis) secondary to hyperplasia of synovial cells, is excess synovial fluid, and the development of pannus in the synovium. The pathology of the disease process often leads to the destruction of articular cartilage and ankylosis of the joints. Cytokines like TNF-a and IL-1 are found to be present in the rheumatoid joint fluids and synovial membranes of patients with rheumatoid arthritis (RA). TNF-a is important in inflammation and tissue destruction, upregulates the production of IL-1 through autocrine and paracrine mechanisms and hepatic synthesis of IL-6. Both IL-1 and TNF-a trigger activation and proliferation of synovial cells, induce collagen synthesis, inhibit proteoglycan synthesis, and stimulate bone resorption, induce production of other cytokines, and upregulate the expression of adhesion molecules on endothelial cells. Thus, cytokines play a crucial role in the pathogenesis of the Rheumatoid arthritis....
Pharmacology is the science of drugs and study of mechanism of action of drugs and lead compounds on the targets or target proteins or receptor molecules. Since ages, pharmacology and pharmaco-therapeutics have emerged and have been contributing to the health sciences and medical industry through its innovation and rigorous hard work in order to find innovative cure and treatment protocols, for the enhancement of the medical sciences and for the benefit of mankind. A newer concept has been coined, which is, “Regenerative Pharmacology”. The regenerative pharmacology is defined as the pharmacology using newer tools and technology in order to reconstruct the receptor targets and cells or organ components, in order to adjust with the newly developed lead compounds for the better outcome of therapeutics applied in order to cure or find solutions for the ever increasing complexity of the diseases and ailments among the human beings. The present letter to the editor has been written to keep in the interest of the scientists and healthcare practitioners across the world, to discuss and have a thought on this newly emerging field of medical science....
Ethnobotany is the study of the symbiotic relationship between humans and plants, more specifically on the ways that humans use plants in everyday life. Ethno botanical species are used as sources of food and medicinal remedies. Across the world, it is still common for plants to be used as a major component in natural medicines. Medicinal plants have also been found to be the number one source of biologically active compounds and many documented medicinal plants have been scientifically proven to have therapeutic applications. In present investigation plant Betula utilis was selected for anticonvulsant and anxiolytic activity. The result shows that the hydroalcoholic extract of bark of Betula utilis was found to be effective against the anti-convulsant as well as anxiolytic activity. The hydroalcoholic extract of this plant is attractive material for the development of a potent phytomedicine for the CNS disorder....
Gastric cancer represents a challenging health problem around the world and is one of the top causes of cancer-related deaths. Challenges in treatment of advanced gastric cancer are due to the relative resistance of disease to treatment, the frequent occurrence of symptomatic disease or impaired performance status of patients, and the propensity of gastric cancer to present when it has become locally advanced or metastatic. Recently, remarkable progress in tumor biology has led to the development of new agents that target critical aspects of oncogenic pathways. This review provides an updated summary of the current status of gastric cancer diagnosis, management, cytotoxic chemotherapy, emphasize on many chemotherapeutic options available and the reasoning that clinicians use in choosing the right treatment option for the right patient. As per the current clinical trial studies the combination therapy shows promising success rate, Pac-5-FU(56%), Cape-Cis(55%), DCF(54%), UFT-Cis(51%), CPT-Cis(50%), 5-FU-Oxal(48%), FOLFOX-4(45%). The advances in individualization of therapy offer a treatment care plan with a high rate of success and minimal toxicity. Recent progress in treatment of gastric cancer includes biologically targeted therapies (a recombinant humanized monoclonal antibody to vascular endothelial growth factor), Monoclonal Antibodies and tyrosine kinase Inhibitors, predictive markers of response, surrogate markers of response, use of nanotechnology whose scope will only increase as the understanding of the pathophysiology and carcinogenesis of this disease improves....
Hyperlipidemia is a major risk factor for atherosclerosis. In animal models ethanol, propylthiouracil, high fat diet and CCT diet are used to produces hyperlipidemia. Ehanol replaces fat as asource of energy and increases total cholesterol level. Propylthiouracil produce hypothyroidism and hyperlipidemia. In high fat diet and CCT diet both are increase the total cholesterol level by their components. Ethanol and propylthiouracil less affect the total cholesterol level as compared to high fat diet. CCT diet more increase total cholesterol level as compared to high fat diet....
Diabetes mellitus (DM) is a metabolic disorder resulting from a defect in insulin secretion, insulin action, or both. Data has been revealed that that more than 200 million people worldwide are having DM and almost it will reach to 300 million by 2025. Elevated glucose level in the blood drives to chronic complication which affects kidney, retina, heart and nervous system. Impaired Insulin secretion and its resistance are the fact of Non Insulin dependent DM, where as Insulin deficiency as the factor of Insulin dependent DM. Hormonal replacement therapy (Insulin injection) is must for the later and the former type is managed by oral hypoglycemic agents. Hypoglycemic agents are shortlisted as Secretagogues and Insulin senziters based on their mechanism like stimulation of �Ÿ-cells of pancreas, enhancing the peripheral uptake of glucose, diminishing the Insulin resistance and inhibition of Gluconeogenisis. Glucose absorption in GUT and re-absorption in the kidney were also targeted in order to get a beneficial activity. Prescription of combinational therapy is the recent trends of the physicians to get better results. Since the status is on progress day by day, a better medicament with limited adverse effects should be bloomed to minimize the morbid status....
Thiazolidinedione moiety serves as a boon in the antidiabetic therapy by increasing the sensitivity towards insulin. 1, 3-thiazolidine-2, 4-dione contains basic skeleton of thiazole or thiazolidine. Presence of carbonyl groups at 2 and 4 positions makes it thiazolidine-2, 4-dione which is basically known for its antidiabetic activity. Objective of this research was to investigate a series of five new synthesized 1, 3 thiazolidine 2,4-dione derivatives for their antidiabetic activity by alloxan induced diabetic model in male wistar rats. Structures of synthesized compounds were confirmed by chromatographic and spectral analysis. The anti-diabetic activity of five new 2, 4-thiazolidinedione derivatives in Alloxan (120 mg/kg) induced diabetic male wistar rats were evaluated by assessing blood glucose, lipid profile, glycosylated haemoglobin and serum insulin. The findings of the present study suggest that 1, 3 thiazolidine 2, 4-dione derivatives produced significant (p<0.05) antidiabetic activity in alloxan induced diabetic rat which is comparable to glibenclamide....
Loading....