Frequency: Quarterly E- ISSN: 2278-4055 P- ISSN: IBI Factor 3.9 Abstracted/ Indexed in: Ulrich's International Periodical Directory, Google Scholar, SCIRUS, Genamics Journal Seek, PSOAR, getCITED, InfoBase Index, EBSCO Information Services
Quarterly published in print and online "Inventi Rapid: Advanced Dosaging" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. This journal focuses on finding the newer methods of administering active pharmaceuticals to the patients either through newer dosage forms of by deploying newer administration devices. The first of its kind of journal, "Inventi Rapid: Advanced Dosaging" invites researchers sharing new insight in achieving the therapeutic goals.
Microencapsulation technique involves surrounding and enclosement of small discrete solid particles or small liquid droplets by an intact shell. It modifies and delays drug release from pharmaceutical dosage forms. Microencapsulation is a vital technique in novel drug delivery system and has a wide scope than conventional multi dose drug therapy. This article involves preperation, properties and uses of individually encapsulated novel small paticles....
Diabetes mellitus (DM) affects over 150 million people worldwide, with a prevalence that varies markedly from population to population. Estimates predict that almost 300 million people will suffer from DM by 2025 with the vast majority being cases of diabetes mellitus type 2. Diabetes is of two types, type 1 accounting for 5% prevalence and type 2 for 95% prevalence among diabetics. The purpose of this review is to provide the reader with knowledge concerning the diabetes treatment using alternative forms of insulin delivery....
In order to increase the retention time of the drug in the body, Floating Microsphere are used which provide the drug release for more than 12 hours. The main purpose of writing this review on floating drug delivery systems (FDDS) is to correlate and compile the recent literature on the principal mechanism and working of floatation to achieve gastric retention. In this article, Various techniques to design single-unit and multiple-unit floating systems with their classification, formulations and Evaluation aspects such as the Particle size determination and Buoyancy are elaborately discussed. The in vitro techniques and in vivo studies to evaluate the performance and application of floating systems are also mentioned. Floating drug delivery system, are useful for various problems encountered during the development of a pharmaceutical dosage form....
In the present study, spherical microbeads are able to prolong and control the release of nifedipin. were prepared by ionotropic gelation method, using sodium alginate as the hydrophilic carrier in combination with HPMC and sodium alginate as drug release modifiers in various proportions to overcome the drug related adverse effects, improve drug bioavailability in different GI tract conditions. Formulated microbeads were investigated for physicochemical properties and drug release potential. All investigated properties showed satisfactory results. While testing size distribution, flow properties and mean diameter of microbeads, there was no significant drug-polymer interactions were observed. The formulated floating alginate beads have shown higher percentage (28.11 % to 39.98 %) of drug loading, particle size (610.75 to 845.62 , higher release of drug. The Optical microscopy of floating alginate beads reveals that the beads are mainly spherical and the use of calcium carbonate, which provides floating property. In-vitro dissolution study showed that 90 % drug release, amongst the formulations, formulation 4 released Nifedipin for prolonged duration (12 hours). Formulated floating beads of Nifedipin showed good swelling behavior....
The aim of the present study was to prepare and characterize compression coated meloxicam tablets using guar gum/hydroxypropylmethylcellulose for effective delivery of drug to the colon. In vitro drug release studies were performed in the dissolution media with and without rat caecal contents. Results showed an enhanced release in rat caecal content when compared to formulation studied in dissolution media without rat caecal content, because of microbial degradation of polymer. The rate of drug release is dependent upon the coat thickness and amount of guar gum/hydroxypropylmethylcellulose used in the formulations. Combination of guar gum and hydroxypropylmethylcellulose K4M provided better protection of the drug, showing increased release lag time and controlled release rate. The nature of the drug transport was found to be non-Fickian (super case-II). Release of drug from tablets began after a time delay as a result of hydrogel swelling/retarding effect, followed by zero-order release for most of the formulations studied. The in vitro drug release studies and in vivo X-ray studies indicated that optimized formulation was a promising system to provide targeting of meloxicam to the colon....
Diabetes patients cannot produce insulin properly which is required to convert sugar, starches, and other food source into energy. Scientists have been looking for simple and effective ways to deliver insulin into the blood stream. The most common one is taking insulin pill orally. However research shows that insulin is easily broken down by the digestive system. This problem is solved by using chewing gum insulin. Compositions containing a therapeutic peptide covalently linked to Vitamin B12 at the 5'-hydroxyl group of the ribose moiety of a-ligand are described. The length of the linkage is optimized so that the biological activity of both the Vitamin B12 and the therapeutic peptide is maintained. Therapeutic peptide includes insulin, PYY, NPY and GLP-1. Attachment to Vitamin B12 provides uptake of the therapeutic peptide from the digestive tract and longer residence time....
Nanorobotics is the technology of creating machines or robots at or close to the microscopic scale of a nanometer. This work presents a new approach with details on the integrated platform and hardware architecture for nanorobots application in epidemic control, which should enable real time in vivo prognosis of biohazard infection. The recent developments in the field of nanoelectronics, with transducers progressively shrinking down to smaller sizes through nanotechnology and carbon nanotubes, are expected to result in innovative biomedical instrumentation possibilities, with new therapies and efficient diagnosis methodologies. It should provide high precision pervasive biomedical monitoring with real time data transmission. Their first useful application was in medicine to destroy cancer cells but the most interesting applications may be in dentistry. This article is a review which enlightens the potential biomedical and dental applications of Nanorobot''s....
Diabetes mellitus is caused due to deficiency in production of insulin by the pancreas, or by the ineffectiveness of the insulin producd.Diabetes mellitus often referred to as diabetes—is a condition in which the body either does not produce enough, or does not properly respond to, insulin, a hormone produced in the pancreas. Insulin enables cells to absorb glucose in order to turn it into energy. This causes glucose to accumulate in the blood, leading to various potential complications. To overcome such complication Indian scientist have develop new techniques for diabetics i.e. single shot insulin which , is very essentials, blessful, create new ray of hope to the patients of diabetics, give relief upto 120 days....
Administration of drugs to children and elderly is not always easy when there is cases of API like antibiotics, analgesics and antidiabetics in which large amount is required to administer then it results in to dosage form which is difficult to swallow orally by paediatrics and geriatrics. Dose Sipping (DS) Technology administering tasteless granules to patients by forming in-situ suspensions in the patient’s favorite beverage requires a complex development of a drinking straw. Each straw contains a single dose of small coated granules containing the prescribed amount of API in a suitably taste masked formulation. Each drinking straw system is individually packed and only removed for oral administration in-situ, while the patient drinks beverages using the straw as they are using every day drinking straw. In this way, there is no need to redisperse the powder or granules prior to administration. While sipping the beverage passes the movable controller and suspends the granules in-situ on the way to the patient’s mouth. After swallowing the suspension complete application of the drug can be checked by looking whether the controller has reached the upper end of the tube....
One promising application of soft robotics is site-specific drug delivery, which aims to deliver drugs directly to the affected site in the body, minimizing side effects and improving treatment efficacy. This review article provides an overview of the advantages soft robots offer over traditional drug delivery methods in site-specific applications, including enhanced precision, controllability and safety. Soft robots can mimic the shape and movements of biological systems, enabling navigation through complex structures like blood vessels, tissues and organs. Moreover, they can be actuated using stimuli such as light, heat and magnetic fields, allowing them to respond to environmental cues and deliver drugs at specific locations and times. The potential of soft robotics in site-specific drug delivery opens new possibilities for personalized and minimally invasive treatments. However, further research and development are necessary to optimize the design, fabrication and control of soft robots and overcome challenges related to their deployment in complex biological environments. This review highlights the current state of the field and provides insights into future directions for advancing site-specific drug delivery using soft robotics....
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