Frequency: Quarterly E- ISSN: 2278-4098 P- ISSN: 2278-4098 IBI Factor: 4.09 Abstracted/ Indexed in: Ulrich's International Periodical Directory, Google Scholar, SCIRUS, Genamics Journal Seek, PSOAR, getCITED, InfoBase Index, EBSCO Information Services
Quarterly published in print and online "Inventi Rapid: Pharm Biotech & Microbio" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. This journal focuses on methods, applications and findings in pharmaceutical microbiology and biotechnology. Papers from all relevant areas such as antimicrobial studies, tissue culture technology, gene methods, enzyme technology, recombinant DNA technology, antibiotics screening and production are invited.
This article provides general understandings about the antibiotic resistance acquired by the bacteria against which the antibiotic was used. This includes the risk related with resistance, causes and mechanism of resistance. Now a days, a number of pathogens have acquired resistance which include S.aureus, Streptococcus, Enterococcus, P.aeruginosa, C.defficile, salmonella, E.coli, Acinetobacter baumanii etc. This leads to multiple drug resistance bacteria, Superbug. This is responsible for increased need to develop newer class of antibiotics....
Quorum Sensing is term to describe the phenomenon whereby the accumulation of signaling molecules enable a single cell to sense the number of bacteria. There are many different bacteria living together which use various classes of signaling molecules in the natural environment. As they employ different languages they cannot necessarily talk to all other bacteria. Nowadays several quorum sensing systems are intensively studied in various organisms such as marine bacteria and several pathogenic bacteria. This review discusses some of the more significant break through in the areas of defining quorum sensing and harnessing quorum signaling for biotechnology that have appeared in the literature over the past few years. A hasty overview of quorum sensing mechanics is provided with greater deliberate of some of the specific functions carried out by extracellular signaling that have emerged recently....
The present review focus on the antiviral and antibacterial potential of seaweeds associated organisms. A large number of seaweeds and associated microorganism extracts and/or extracellular products have been found to have antibacterial activity, the antibacterial activity of aquatic microalgae was reported for Chlorella vulgaris. The antiviral effects of polysaccharides from marine algae toward mumps virus and influenza B virus were reported . Subsequently, polysaccharides fractions from extracts of red algae were found to inhibit herpes simplex virus (HSV) and other viruses. Compounds extracted from algae have in vitro or in vivo activity against a wide range of retroviruses, including herpes viruses (HSV-1, HSV-2, HCMV), togaviruses (Sindbis virus, Semliki Forest virus), paramyxoviruses (RSV), rhabdoviruses (vesicular stomatitis virus [VSV]), and human immune deficiency viruses (SIV, HIV) and also to on antimicrobial, antiprotozoal activity. Parasitic protozoans are single-celled organisms causing serious tropical diseases worldwide in both humans and animals. Malaria, trypanosomiasis and leishmaniasis are among the major parasitic diseases, seaweeds and associated microorganisms showed promising biopotential against them....
The use of antibiotics has rapidly increased after the discovery of penicillin made by Alexander Fleming. Since then, thousands of antibiotics from microbial origin have been discovered. The use of antibiotics in the past decades has led to a rapid evolution in microbes because of naturally occurring multi-drug resistant genes to antibiotics, so there is a need for novel antibiotics. Naturally soil is rich in microorganisms capable of antibiotic synthesis. Soil samples from the Siddhapudur region, Coimbatore, Tamil Nadu were screened for antibiotic producing microorganisms by crowded plate technique. Six strains were suspected to produce antibiotics based on the clear zone around the colony. The bacterial species were characterized by its cellular characteristics, colonial morphology and biochemical tests. The isolates tested against Staphylococcus aureus, Proteus vulgaris, Pseudomonas aeruginosa and Escherichia coli for its antibacterial activity. All the isolated colonies were screened for antimicrobial activity. Growth curve of the selected isolate was plotted against time and it was clear that secondary metabolite produced during third day. The results revealed that, though the entire isolates produced clear zone in crowded plate technique five strains fails to show antibacterial activity against tested strains. Isolate I and V produces antibacterial activity. The results suggest that soil isolates from the selected region having antibiotic producing ability and it could be utilized commercially after proper potentiation and standardisation....
The methanolic extract of the egg mass from C. catla was studied for the antibacterial activity against ten human pathogenic bacteria. The antibacterial activity of the methanolic extract from the egg mass of C. catla displayed zone of inhibition 19, 14, 17, 13, 14, 18, 10 and 12 mm against S. aureus, K. pneumoniae, S. typhi, K. oxytoca, S. paratyphi, E. coli, P. mirabilis and S. pyogenes at the highest concentration of 100 µg/ml. Further, the methanolic extract detected the MIC values of 80 µg/ml against E. coli and the S. typhi and E. coli were 100 µg/ml concentration. MBC value of the methanolic extract was 80 µg/ml against E. coli and the S. typhi and E. coli were 100 µg/ml concentration. Whereas the K. pneumonia, K. oxytoca, S. paratyphi, P. mirabilis and S. pyogenes were slightly arrested at 100 µg/ml. The methanolic extract from the egg mass of C. catla showed the anticancer activity of 8.02%- 30.41% at 50 - 250 µg/ml concentrations. Hence, from the above antibacterial and anticancer activity of the methanolic extract from the egg mass of C. catla, recommend it as a good biological agent in future pharmacological industry....
Mastitis is one of the costliest diseases affecting the livestock and incurs huge production losses and also involves high cost of treatment. Milk samples were obtained from the suspected mastitis animals from different parts of the Krishna district. Milk samples collected from different areas and sources were put to mastitis field surf test, white side test. Then the samples found positive were cultured on tryptose agar, MacConkey’s agar and blood agar. The cultures thus obtained were subjected to antibiotic sensitivity test (Disc diffusion method) using 10 commonly used antibiotics in the field to determine the antibiogram....
Cyanobacteria in general and marine forms in particular are one of the richest sources of known and novel bioactive compounds including toxins with wide pharmaceutical applications. The anti-inflammatory activity of marine cyanobacteria, Oscillatoria salina was studied in carrageenan - induced inflammation in rats. The ethanol extract of Oscillatoria salina showed anti- inflammatory activity at a high dosage (400 mg/kg) and this effect was on par with the commercial drug, indomethacin. The inhibition of inflammation volume was 65.8? 0.4 % and 48.7?0.4 % respectively at higher and lower dosages, in 30 minutes of treatment. The control group without any treatment exhibited an increase in the paw volume. The results indicate, further isolation of the anti-inflammatory molecules will be derived from Oscillatoria salina....
Hemidesmus indicus (L) radix (asclepediace) is being used widely in ayurvedic medicine. Literature survey revels those plant posses the diuretic, antifungal, antipyretic, anti-inflammatory, antioxidant, antibacterial, blood purifier property, Aim of the present study is to determine the antibacterial activity of Hemidesmus indicus (L) radix various extract like Petroleum ether and Chloroform....
Distilled cow urine commonly known as “Gau Mutra”, is a well-known medicament in Indian traditional medicine. On the basis of its traditional use and literature references, this plant was selected for evaluation of its antimicrobial activity against Staphylococcus aureus, Pseudomonas aureogenosa, Staphylococcus epidermis, Shigella flexineri, Bacillus substilis , E. Coli.& S.aureus,Bacillus subtilis, S.epidermidis using the agar well (cup plate) diffusion method. Distilled cow urine inhibited the growth of gram positive bacteria, with zone of inhibition between 7 - 10 mm, and a gram negative bacterium with zone of inhibition between 9-12mm. The activities of the distilled cow urine on the inhibited pathogens using the zone of inhibition were not as effective as the standard commercial antibacterial disks of tetracycline, Ofloxacin, Azithromycin, Piperacillin, Nitrofurantoin, Gentamicin, Cefotaxime, Norfloxacin....
Bacillus subtilis is the potential probiotic species. Spores of various Bacillus species including B. subtilis, B. cereus, B. pumillis, B. clausii, B. amyloliquefaciance, B. coagulance are being used as probiotic. Bacillus species are highly resistant to heat, spore forming and ideal food additives for animal. B. subtilis has the ability to produce large number of secretory proteins, enzymes and antimicrobial compounds (Bacteriocin). B. subtilis species are gaining interest in human health related to food research with their enhanced tolerance and survivability under hostile environment of gut. These bacilli are more stable during storage, processing of food and pharmaceutical preparation. B. subtilis is associated with beneficial bioactivities such as production of vitamins and immune stimulation, It has great potential to be used as an alternative to antimicrobial drug. Inoculations of B. subtilis strain WS-1 by oral feeding in animal were able to inhibit diarrhea and also death caused by pathogenic E. coli in animal. B. subtilis WS-1 strain could protect small intestine from lesion caused by E. coli infection. B. subtilis is also considered as plant growth promoting rhizobacterium, under stressful condition they produce volatile organic compound (VOC) and helps to resist pathogenic attack. In another aspect, non-recombinant and recombinant spores of B. subtilis used as a delivery system of mucosal immunization. Thus, B. subtilis as potential probiotic has shown its effectiveness as anti-diarrheal, antimicrobial, immunomodulator, improve growth performance, improve gut microflora, plant growth promoter and carrier in mucosal drug delivery system....
Loading....