Frequency: Quarterly E- ISSN: 2278-408X P- ISSN: IBI Factor: 4 Abstracted/ Indexed in: Ulrich's International Periodical Directory, Google Scholar, SCIRUS, Genamics Journal Seek, PSOAR, getCITED, InfoBase Index, EBSCO Information Services
Quarterly published in print and online "Inventi Rapid: Novel Excipients" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. It focuses on new pharmaceutical excipients from natural and synthetic origin. Articles pertaining to excipients for conventional dosage forms as well as novel drug delivery systems and nano-medicines are welcome.
Tablet disintegration is an essential step for fast drug release. Disintegrants are substances or mixture of substances added in drug formulations which increases dispersion or breakup of tablets and capsules into smaller particles for fast dissolution. Fast dissolving, fast melting, chewable and orally dissolving or disintegrating tablets are solid dosage forms that disintegrate rapidly and dissolve in the mouth without water. These products have staying power in the marketplace because they have great appeal to consumers and increased compliance among users. The main challenge with orally disintegrating tablets is to develop tablet formulations having rapid disintegration, pleasant mouth feel and high breaking force for tablet robustness. The disintegration of dosage forms depends upon various physical factors of superdisintegrants percentage of disintegrants used, proportion of disintegrants used, compatibility with other excipients, and presence of surfactants and hardness of the tablets, nature of drug substances and mixing and types of addition. Mechanisms for tablet disintegration are swelling, porosity and capillary action (wicking), deformation, enzymatic reaction, due to disintegrating particle/particle repulsive forces, heat of wetting, due to release of gases and combination action. Natural Superdisintegrants includes mucilage of Isapghula Husk, Cress, Gum Karaya, Fenugreek Seed and gum of Locust Bean, Chitin and chitosan, Gellan, Agar, Alginates, Soy polysaccharide, Cassia fistula, Xanthan, Cucurbita maxima pulp powder, Hibiscus rosa-sinensis Linn. Mucilage and Mango Peel Pectin. Synthetic Superdisintegrants includes Cross-linked polyvinyl pyrrolidone (crospovidone, Polyplasdone XL, XL10), Microcrystalline Cellulose (Avicel), Modified Cellulose (croscarmellose sodium, Ac-Di-Sol), Sodium Starch Glycolate (Explotab, Primogel), Resins, Calcium Silicate and Ion exchange resins....
The present investigation was aimed at investigating the potential of Pistacia Vera Linn. outer seed shell powder (PV-SSP) as superdisintegrant while formulating orodisperse exhibiting lowest disintegration time with enough mechanical strength. Interaction of piroxicam (PX) and β-cyclodextrin (β-CD) was investigated in solid state. Solubility studies demonstrated that the formation of PX- β-CD inclusion complex with 1:1 stoichiometry. Orodisperse prepared with PV-SSP (10% w/w) were directly compressible and showed superior disintegrating property due to decreased water sorption time, wetting time, increased water absorption ratio, without any significant change in swelling index. The mechanism of superdisintegration suggested that when PV-SSP used in formulation and compressed into tablet it get deformed and after contact in water these deformed particles get into their normal structure and produces a break-up of the tablet. The in-vitro release results displayed that orodispersible tablet containing PX- β-CD solid complex displayed faster PX release compared to those containing free drug. Thus, the findings signalled great potential for using PV-SSP as superdisintegrant in orodisperse with low disintegration time....
Aceclofenac is non-steroidal anti-inflammatory drug used for the treatment of inflammation and pain caused by rheumatoid arthritis and osteoarthritis. It has a half life of about 4 hrs and is characterized by low solubility and high permeability. It is poorly water soluble drug and when administered orally it may cause bioavailability problems due to its poor solubility and dissolution rates in biological fluids. Hence there is need to enhance the solubility of aceclofenac for rapid therapeutic effect and increased bioavailability. So in the present work was aimed at increasing the rate of dissolution of aceclofenac thus providing faster rate of absorption by adding potential superdisintegrants like novel superdisintegrant starch butyrate and known superdisintegrants like sodium starch glycolate and croscarmellose sodium in different concentrations....
Aceclofenac is non-steroidal anti-inflammatory drug used for the treatment of inflammation and pain caused by rheumatoid arthritis and osteoarthritis. It has a half life of about 4 hrs and is characterized by low solubility and high permeability. It is poorly water soluble drug and when administered orally it may cause bioavailability problems due to its poor solubility and dissolution rates in biological fluids. Hence there is need to enhance the solubility of aceclofenac for rapid therapeutic effect and increased bioavailability. So, the present work was aimed at increasing the rate of dissolution of aceclofenac thus providing faster rate of absorption by adding potential superdisintegrants like novel superdisintegrant starch maleate and known superdisintegrants like sodium starch glycolate and croscarmellose sodium in different concentrations....
Starch isolated from Borassus flabellifer (Arecaceace) plant was studied as an alternative pharmaceutical excipient to maize starch. The B. flabellifer starch has been evaluated by series of tests as mentioned in Indian Pharmacopoeia before being used for evaluation. It was tested along with maize starch as an alternative excipient by performing battery of preformulation and formulation tests. Preformulation studies like sieve analysis, micrometry, flow properties, moisture content and compatibility studies were done as per recommended procedures. The tablets were prepared by wet and dry granulation using paracetamol and aspirin respectively, with B. flabellifer starch as binder, disintegrant, binder and disintegrant and tablets were evaluated. The results obtained for B. flabellifer starch were comparable with maize starch and the B. flabellifer starch can be used as a pharmaceutical excipient in tablets preparation....
In market solid orals gain maximum popularity, because of many advantages over others. Orally disintegrating tablets (FDTs) are an emerging trend in novel drug delivery system (NDDS) and have received ever-increasing demand during the last few decades.FDTs disintegrates or dissolves rapidly in the mouth without chewing and water. This type of property in dosage form can be attained by addition of different excipients, from which disintegrant is the key adjuvant. Diverse categories of superdisintegrants such as synthetic,semi-synthetic,natural and co-processed blends etc. The present review comprises the various kinds of superdisintegrants like natural and synthetic which are being used in the formulation to provide the safer, effective drug delivery with patient''s compliance and improve efficacy of dosage form. This is achieved by decreasing the disintegration time which in turn enhances drug dissolution rate. Super-disintegrants are generally effective in a low concentration, and generally at higher concentrations they hinder disintegration. The present review describes super-disintegrants, their types, selection criteria and various methods of incorporating disintegrants and mechanism of tablet disintegration....
Many natural plant products like gum, mucilage,starches etc are used as pharmaceutical excipients for design of formulations. The seeds of Phaseolus mungo & Phaseolus roxburghi have been taken for isolation of excipients and evaluation was carried out by different methods including Phytochemical analysis and Analytical study. Characterization of isolated excipients was done with different parameters like absorption capacity, solubility etc .All results lies within the limits for modification or design of dosage form....
Taro has been reported to have 70–80% starch with small granules, Because of the small sizes of its starch granules, taro is highly digestible. On the basis of current evaluation of properties of starch it has been found that taro starch can be utilized as a better disintegrant as compared to the other traditional starches, Starches are used since a long time as exipients in pharmaceutical preparations. Mainly maize starch, potato starch and wheat starch are used and monographed in several pharmacopoeias. The classical functionalities of native starches in the past are fillers and disintegrants in tablets and fillers in dermatological powders. Also modified (pregelatinized) starches have been used as filler-binders in tablet technology. After this research activity Taro starch can be introduced in the pharmaceutical field and further more research can be done over this starch to make it highlighted in the arena of pharmaceutical research. In addition to food use, taro has found some industrial applications. The very small size of taro starch granules makes them ideal in cosmetic formulations like face powder and in dusting preparations which use aerosol dispensing systems. In spite of the above uses, the large-scale extraction and utilization of this starch is not practised anywhere. So after this research activity the taro starch can be brought to the minds of researchers and it can gain attention in the field of pharmaceutical research....
Nature has provided us a wide variety of materials to help improves and sustains the health of all living things either directly or indirectly. Many herbal medicines have been recommended for the disease. Many polysaccharides have been finding, very interesting and useful application in the biopharmaceutical field. A large number of plant based excipients are available today. They have been extensively explored as pharmaceutical excipients. Fenugreek gum is one of them that have wide potentiality in drug formulation due to its extensive application as food additive and its recognized lack of toxicity. Through the keen references of reported literature on fenugreek gum. We have described critical aspects of fenugreek seed mucilage, its manufacturing process, physicochemical properties and application in various drug delivery systems....
The purpose of this research was to develop fast disintegrating tablets of Salbutamol Sulphate using a combination of super disintegrating agents for enhancing the dissolution rate. Recently Fast Disintegrating Tablets (FDT) have started gaining popularity and acceptance as Novel Drug Delivery Systems (NDDS), because they are easy to administer and lead to better patient compliance. Salbutamol Sulphate is a selective β2 receptor agonist widely used as a bronchodilator. It forms part of initial therapy of acute as well as chronic asthma. In present work an attempt has been made to formulate and evaluate fast disintegrating tablets of Salbutamol Sulphate. Ac-di-sol (CCS), Polyplasdone–XL (CPV) and Primojel (SSG) were used as super disintegrating agents individually and in combinations of two super disintegrants (CCS: CPV; CCS: SSG and CPV: SSG) in the ratio 1:1 respectively for to study the effect of combination on the physical and dissolution parameters of the, while Mannitol (Pearlitol SD 200) is used as diluent. Direct compression technique was used as it requires conventional tablet machinery and thus process is economical. Formulations containing combination of super disintegrants CCS: CPV in the ratio 1:1 show rapid in-vitro and in-vivo dispersion time and faster dissolution rate as compared to other formulations....
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