Frequency: Quarterly E- ISSN: 2320-1029 P- ISSN: IBI Factor: 4.09, Global Impact Factor 0.76 Abstracted/ Indexed in: Ulrich's International Periodical Directory, Google Scholar, SCIRUS, Genamics Journal Seek, PSOAR, getCITED, InfoBase Index, EBSCO Information Services
Quarterly published in print and online "Inventi Rapid: Pharmaceutical Process Development" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. It focuses on multidimensional aspects of pharmaceutical process development, particularly ingredients and equipment selection, scale-up and pilot plant studies, factoring environment, automaton and robotic procedures, in-process characterization, bioprocesses etc.
In this review it is necessary to understand the capacities of the pharmaceutical industry to meet the new challenges arising from the TRIPS Agreement. In past, pharmaceutical industry did not face any rigours of strong patent systems. The new situation is going to be totally different. This article will give brief review on pharmaceutical market of India, Indonesia, Sri Lanka and a co-relation between the pharmaceutical policy and the patent laws has to be established to the maximum extent so that the industry is able to play its role adequately to facilitate easy access to medicines at competitive prices. Rising research and development (R&D) expenditures by pharmaceutical industries are, in part, a consequence of changing industry structure, notably the increase of the biotechnology sector....
With the objective of reducing analysis time and maintaining good efficiency, there has been substantial focus on high-speed chromatographic separations. Recently, commercially available ultra-performance liquid chromatography (UPLC) has proven to be one of the most promising developments in the area of fast chromatographic separations. In this work, a new isocratic reverse phase chromatographic method was developed using UPLC for Ziprasidone Hydrochloride Monohydrate. The newly developed method is applicable for assay determination of the Ziprasidone in capsule dosage form. The chromatographic separation of Ziprasidone was achieved on a Zorbax SB C-8 (50 x 4.6) mm, 3.5 µm column within a short runtime of 2 min. The method was validated according to the International Conference on Harmonization [ICH] guidelines with respect to specificity, precision, linearity, accuracy, range, stability of analytical solution, robustness and system suitability....
The ability to deliver the same quality could be a necessity for remaining in business in an extremely regulated and quality vital pharmaceutical sector. There is an increasing target creating the production simpler and optimizing processes to deliver consistent quality. Pharmaceutical corporations follow the trend of product transfer to boost the potency of production and improve the standard of prescription drugs. Many times product transfer helps to regain the company�s position within the drug company world. Comparison studies ought to be taken into thought before following the merchandise transfer method followed by standardization and validation of the batches before exploiting industrial edges. Standardization is that the act of optimizing the method parameters for continuous production of the merchandise. Validation could be a gismo of quality assurance that has conformation of the quality in equipment, manufacturing approach, code and methodology used for testing. Quality of finished product that depends on many concern like, assortment of quality elements and material, adequate product and manufacturing procedure vogue, management of method variable and consequence testing. Method validation deliver assurance that manufacturing product is appropriate for doomed purpose and unfailingly meet pre-set specification and quality attributes as per mounted master formula record. It collectively provides a documented proof for the structure and schedule of producing product and to figure out the vital method parameter and variables in manufacturing method of tablets....
Stability means the time during which the drug product remain in its same property and characters. Stability study necessary during the decomposition of active drug, toxic product may be formed. In manufacturing, good formulation will taken long time for decomposition. Drug degradation has studied individually but it time consuming. In accelerated stability testing to predict the shelf life of a product by accelerating the rate of decomposition, preferably by testing the temperature of reaction condition. In this rapid detection in the formulation prediction of shelf life, protect reputation of producer, established storage condition. There are different stages of drug development during stability study. Some basic principle of stability testing follow during testing of product i.e. selection of batches and samples, testing criteria, analytical procedure, specification, storage condition, number of batches, packaging material, evaluation, testing frequency, storage period, stability information....
The objective of the present study was to develop tablet formulations of Nervine tonic. Dispensing and consumption of powder is inconvenient to the patients while in case of decoction stability problems are always. Hence, in the present investigation, an attempt was made to prepare tablet formulations of extract of plant Bacopa monnieri, Celastrus paniculatus and Centella asiatica which improve patient compliance and acceptability. Tablet formulations were developed by wet granulation technique using starch as binder. The granules were evaluated for precompression parameters like angle of repose, bulk and tapped densities, percentage compressibility and the tablets were evaluated for postcompression parameter like weight uniformity, hardness, friability and disintegration time....
An RP-HPLC method has been developed for the simultaneous estimation of moexipril (MP) and hydrochlorothiazide (HCTZ) in tablet dosage forms. . Optimum separation was achieved by using symmetry C18 (4.6x150 mm, 5, mm) with a mixture of acetonitrile (ACN): Phosphate buffer at pH 3.0 and in the ratio of 43:57 at a flow rate of 0.5ml/min. The detection was carried out at 216nm and retention time was found to be10 min. The developed method was validated as per ICH guidelines. Linearity range was found to be 20 to60 μg/ml forMP&HCTZ. . In the linearity study, regression equation and coefficient of correlation for MP and HCTZ were found to be (y = 269747x +94514.74, r2 =0.999) and (y = 194376x+795863.8, r2 = 0.999) respectively. This newly developed method was successfully utilized for the simultaneous estimation of moexipril andhydrochlorothiazide in pharmaceutical tablet dosage forms....
The auditory brainstem response (ABR) deals with ongoing electrical activity inside the brain and recorded through electrodes placed on the scalp. The resulting recording is a series of vertex positive waves in which I through V are evaluated. These waves labeled with roman numerals in Jewett and Williston convention and occur in the first 10 milliseconds after onset of an auditory stimulus. The ABR is considered an exogenous response due to its dependence upon external factors. The ABR is applying for newborn hearing screening, auditory threshold estimation, intraoperative monitoring, determining hearing loss type and degree, and auditory nerve and brainstem lesion detection. The ASSR utilizes statistical measures to determine differential diagnosis....
Olmesartan medoxomil is an AT1 subtype selected angiotensin-II receptor antagonist approved for the treatment of hypertension. It has low water solubility, so the current effort is being made to enhance the solubility of the Olmesartan by inclusion complex and to incorporate them into tablets by direct compression. Complexing agent like Beta cyclodextrin and polyvinyalpyrrolidone has been used for complexation method. FT-IR studies have shown that there is no link between drugs and complexing agents. Among all methods, the inclusion complex (OLBCD 3) containing the drug: Beta cyclodextrin in a 1: 3 ratio showed rapid drug release (87.41% within 30 minutes) and post compression parameters are within limits. All the values obtained from pre compression and post compression parameters meets the legal requirements for tablets. Stability studies of batch no OLBCD 3 shows no significant change. Therefore, it can be concluded that the structure was stable....
Tablet coating is a common pharmaceutical technique of applying a thin polymer layer which is prepared either into the aqueous solvent system or non-aqueous solvent system. Tablet coating is also carried out by preparing the drug coating solution. The main reason of coating the tablets are mainly taste masking, due to unpleasant odour, enhancement of the drug stability, appearance of the tablet and rough surface and so on. This problem can be overcome by using the aqueous solvent system rather than using the non-aqueous solvent system because this aqueous solvent system is not harmful to the human who are working in to the development area. Film coating technique is also consider for the controlled release tablet. Spray atomization technique is most useful for film coating of tablet....
Drug Discovery has been tedious and time consuming task ever since the humans started their endeavor in discovering and inventing drugs. The current and new age discovery and innovation of artificial intelligence will help in automation of operations in present case. The amount of data produced in current scenario is huge and this huge big data isn’t possible for humans to analyze and interpret. Here is the role of Artificial intelligence which can mimic the possible intelligence of the human brain and can do the task at highly astronomical speed and accuracy. The present letter has been written to highlight the importance of AI in drug discovery science....
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