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Quarterly published in print and online "Inventi Rapid: Genetics (Formerly Inventi Rapid: Stem Cell)" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal focuses on all aspects of stem and progenitor cell biology. It invites articles related to stem cells, embryonic stem cells, induced pluripotent stem cells, tissue-specific stem cells, stem cell technology, epigenetics, genomics, proteomics, and metabonomics. Articles from cancer stem cells, translational and clinical research and regenerative medicine are also welcome.
Malaria has been one of the leading causes of death among children globally, making it one of the most powerful known factors for evolution in the recent history of humans. For single nucleotide polymorphism, it is becoming more crucial to predict and comprehend the impacts of genetic variation that happened in the gene in order to comprehend the molecular basis of hereditary disease. The tumor necrosis factor (TNF) gene that causes malarial disease was discovered through a review of the literature. This TNF gene was thoroughly examined in this study utilizing computational approaches to identify the genetic variation responsible for changing the expression and functionality of the gene. Following gene analysis, it was envisaged that the protein produced by the gene would have a significant role in generating the significant change in the gene. Further research was done on the disease-causing protein using the SNP analysis method and it was expected that the specific mutation that happened in the protein affected the function and structure of the gene. By substituting the original amino acid into the protein's suggested structure and sequence using a bioinformatics tool, an effort was made to stop the mutation. To confirm that the protein that was responsible for the gene alteration in malarial disease would operate normally once the necessary modifications are made in the protein that was indicated by computational methods, more clinical investigations can be conducted....
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