Frequency: Quarterly E- ISSN: Awaited P- ISSN: Abstracted/ Indexed in: Ulrich's International Periodical Directory, Google Scholar, SCIRUS, EBSCO Information Services
Quarterly published in print and online "Inventi Rapid: Medicine (Formerly Inventi Rapid: Holistic Medicines)" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal focuses on alternative healthcare systems having wholesome or holy approach towards the health and disease management. Articles are invited from such areas as Ayurveda, Unani, Tibb, Homeopathy, Chiropractic, Osteopathy, Naturopathy, Massage Therapy, Meditation, Acupuncture, Crystals, Natural Diet and Herbal or Home Remedies.
Drugs can be fatal weaponry and we must memorize that the well-being of our patients are in our hands. Prescribing rationally must be related to every aspect of the art of general practice include patient-centered care, clinical skills and good judgment, familiarity of epidemiology. Ongoing medical education is imperative for the general practitioner. Little time is exhausted commerce with the essentials of therapeutics and all that is implicated in the suitable, rational usage of drugs....
The aim of the study was to assess knowledge, attitude and practices towards chronotherapy among final year students of medical, pharmacy and nursing. A prospective questionnaire based study was conducted in students of final year Medical, Pharmacy and Nursing of a tertiary care teaching hospital. The questionnaire consists of four parts which includes socio-demographics, knowledge, attitude and practice towards chronotherapeutics. Data collection was done in 300 students of final year medical, pharmacy and nursing. The filled questionnaires were evaluated using descriptive statistics and analysed using mean and standard deviation. With regards to mean total knowledge, results showed that there were significant difference between medical and pharmacy (p = .000) and also, medical and nursing (p = .000). Results also showed that there was significant difference between Pharmacy and Nursing (p = .000). In terms of mean total attitude, there was no significant difference between medical and pharmacy (p = 1), but there was a significant difference between Medical and Nursing (p = .000) and pharmacy and nursing (p = .000). In terms of mean total practice, there was a significant difference between medical and pharmacy (p = .000), as well as medical and nursing (p = .000) and also a significant difference between pharmacy and nursing (p = .000) in the results. From the study, it can be observed that, the final year students of medical faculty are more aware of chronotherapy in comparison to final year students of pharmacy and nursing faculties....
Drug use studies are an integral part of medical audits and are often conducted to monitor and evaluate prescribing practices. The primary goal of rational drug use is to ensure that patients receive medications that are appropriate to their clinical needs, in doses that meet their individual requirements for an adequate duration and at the lowest cost to both the patient and the community. Irrational drug use can occur through polypharmacy, underuse, or improper use of effective medicines. This study aims to evaluate prescribing patterns and the rationality of drug use in the General Medicine Department of a tertiary teaching hospital (Navodaya Medical college Hospital and Research Centre, Raichur, Karnataka, India). A prospective observational study was conducted over six months, enrolling 100 patients admitted as inpatients. Prescription data from seriously ill patients and those transferred to the ICU were excluded from the study. Data were analysed using descriptive statistics, such as mean and percentage. The study found that the majority of participants (37%) were elderly, indicating a higher representation of older patients, while 30% were middle-aged and only 11% were in the youngest age group. Gender distribution was nearly equal, with male patients comprising 49% and female patients 51%, resulting in a male-to-female ratio of 1:1. Most patients (57%) were discharged within 1-5 days, suggesting that most admissions involved mild or less complicated cases. A significant portion of patients (29%) stayed for 6-10 days, while only 11% stayed for 10-15 days and 3% stayed for 15-20 days. The study also observed that infectious diseases (6.30%), respiratory diseases (32.43%), cardiovascular disorders (2.70%), central nervous system disorders (4.50%), gastrointestinal disorders (3.60%), renal disorders (2.70%), liver disorders (6.30%), Anaemia (10.81%) and thyroid disorders (10.81%) were among the most common diagnoses, with other conditions including fever under evaluation, pancytopenia, acute febrile illness and fever under observation (27.02%). In the pre-interventional phase, the average number of drugs per prescription was 7.47. The percentage of drugs prescribed by generic names was 55.15%, the percentage of injections prescribed was 44.71% and the percentage of antibiotics prescribed was 21.40%. Furthermore, 57.29% of drugs were prescribed from the essential drug list. In the post-interventional phase, the average number of drugs per prescription decreased to 5.42, the percentage of drugs prescribed by generic names increased to 64.02%, the percentage of injections prescribed dropped to 20.21% and the percentage of antibiotics prescribed rose to 36.53%. Drugs prescribed from the essential drug list increased to 62.36%. Drug-related problems included adverse drug reactions (ADRs) in 2% of patients, medication errors observed in 33% and drug-drug interactions in 18%. The study highlights the over-prescription of antibiotics and the prevalence of irrational drug use, particularly in the pre-interventional phase. However, following educational interventions for healthcare professionals, rational prescribing practices were significantly improved. The study underscores the need for policies and procedures to guide prescribing practices and optimize cost-effective drug therapy, ultimately improving patient outcomes and quality of life....
Drug use evaluation in obstetrics and gynecology is important because it helps to ensure the safety of both the mother and the fetus. Drug use during pregnancy can have consequences, including fetal risk, physiological change. Our study aimed to analyze drug usage in OBG as per FDA-pregnancy risk categories and also to assess rationality using WHO Drug use indicators. A Prospective observational study was conducted for a period of six months at a tertiary care teaching hospital with a sample size of 110. Pregnant women who were given oral consent were included in the study. Along with demographic data, the total number and categories of drug prescribed, percentage of individual drugs in each category etc were recorded. US FDA Risk drug category for pregnancy were also assessed. Data was analyzed using descriptive statistics like mean, frequency and percentage. In our study, among 110 participants 31.8% were age group of 18-23 years followed by 50% in the age group of 24-29 Mean age of participants was 36.6±2.2 years. Out of 110 participants, majority (55%), were undergraduates, followed by 29% who were generally educated. Only 15% of the population has postgraduate qualification. Almost 53(48.1%) were in first trimester of pregnancy while 38 (34.5%) were in second trimester and 19 (17.2%) were in third trimester, the most frequently conducted test was CBC (80%), followed by urine culture (25%), ESR (20.05%), C – reactive protein (17%), hepatitis (5%), HIV (3.4%), cervical culture (8.6%), pap test (6.8%). The most common supplements that were prescribed, includes iron (30.9%) and Folic acid (27.6%). Antibiotics being the most prescribed (22.1%), followed by antacids (19.5%) and antiemetics (17.2%), Average number of drugs per prescription was 6.4, percentage of drugs prescribed by generic name was 66.1, percentage of injection prescribed was 25.71, percentage of antibiotics prescribed was 38.40, percentage of drug prescribed from essential drug list was 60.2. Category A includes Vitamin supplements like Iron (30.9%) drug and folic acid (27.6%) drugs. Category B comprises antiemetics, antacids, antifibrinolytics and partial antibiotics with the highest count of 172 drugs (56.03%). Category C includes NSAIDs, analgesics and antipyretics, anthelmintics and miscellaneous drugs, totaling 95 drugs (30.94%). Category D consists of NSAIDs, Partial Antibiotics, Analgesics and Antipyretics, contributing 30 drugs (9.77%). No Category X drugs was prescribed. Our study findings revealed that the medications prescribed to pregnant women in obstetrics and gynecology department were appropriate. However, there is a need for periodic reviews of the safety, efficacy and appropriateness of drugs, prescribed to this population. This will help to minimize the use of contraindicated medications and ensure optimal health outcomes for both mothers and their newborns....
Polycystic ovary syndrome (PCOS) is one of the most common disorders that occur in women of any age due to an endocrine hormone imbalance. There is an urgent need for the development of novel natural PCOS medications free from adverse effects because the underlying cause of this condition has not yet been discovered. It was observed from a literature review on medicinal plant species that the phytochemicals present in the plants have the ability to increase the function of hormones for fertility. The goal of the ongoing research is to identify novel medication candidates from the medicinal plants that could be used to treat the target PCOS protein. An assessment of the medicinal plants revealed 145 phytochemicals that have been discovered through research. After in-silico screening for its drug likeness and structural reaction towards biological functions, only 23 compounds of the medicinal plants demonstrated the oral drug response, while other compounds failed to pass oral drug tests. Using docking studies, these compounds were further examined for their ability to bind to the PCOS protein Cytochrome P450 (CYP). The current findings suggest that the strongest binding affinity interactions with the target protein are only present in two compound. Based on the findings of this study, the predicted plant components can be identified and extracted for additional in-vitro and in-vivo testing to establish the safe dosage for PCOS patients....
Hospitalized patients who are initially on IV medication can be safely stepped down to an oral equivalent drug when the patient is clinically stable. The aim of the study was to retrospectively evaluate the practice of stepdown therapy in antibiotics and PPIs and its impact on length of hospital stay. The study was conducted in a tertiary care hospital with sample size of 200, each 100 patients for IV PPI and IV antibiotics. Case records of patients who received IV PPIs and antibiotics during the year 2020 were included in the study and Out patients were excluded. Out of all IV to Oral conversions, Sequential therapy was commonly used in PPIs and switch therapy was preferred for antibiotics. Average days of treatment with IV PPI in switch was 2 days and sequential was 2.217 days (p=0.733). Average days of treatment with oral PPI in switch was 3.333 days and sequential was 4.237 days (p=0.399). In case of antibiotics therapy average days of treatment with IV in stepdown was 6.677 days, switch 5.058 days and sequential is 4.059 days (p=0.00). In Oral therapy the average days of treatment with oral drugs were stepdown 5.323 days, switch 4.865 days and sequential therapy was 4.235 days (p=0.149). Length of hospital stay for patients had significantly decreased in PPIs switch therapy (p=0.337) and in case of antibiotics sequential therapy (p=0.001). Cephalosporins and penicillin were most commonly converted Antibiotics. Timely conversion of drugs from IV to oral therapy can reduce the length of hospitalization for patients....
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