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Quarterly published in print and online "Inventi Impact: Dermatology (Formerly Inventi Impact: Derma)"publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal welcomes papers in all the areas of dermatology including clinical and investigative studies, treatments, new diagnostic techniques, and other topics relating to the prevention, diagnosis, and treatment of disorders of the skin.
Introduction. A validated assessment of pruritus intensity is an important but still difficult clinical problem due to a subjective nature\nof this sensation. Objective.The aim of this studywas the creation and validation of newitch severity questionnaire assessing pruritus\nintensity. Material and Methods. A total of 148 patients with pruritic dermatoses were asked to assess pruritus intensity using 12-\nItem Pruritus Severity Score (12-PSS) and Visual Analogue Scale (VAS). Patients were also asked to complete the Dermatology Life\nQuality Index (DLQI) and Hospitality Anxiety and Depression Scale (HADS). Test-retest comparison of 12-PSS was conducted\nin 102 subjects who completed the itch questionnaire twice with the 3- to 5-day interval. Results. We have created the 12-PSS\nassessing pruritus intensity (two questions), pruritus extent (one question) and duration (one question), influence of pruritus on\nconcentration and patient psyche (four questions), and scratching as a response to pruritus stimuli (four questions). A maximum\nscoring was 22 points. The results showed strong consistency (Cronbach ...
An oral marine protein supplement (MPS) is designed to promote hair growth in women with temporary thinning hair (Viviscal\nExtra Strength; Lifes2good, Inc., Chicago, IL).This double-blind, placebo-controlled study assessed the ability of MPS to promote\nterminal hair growth in adult women with self-perceived thinning hair associated with poor diet, stress, hormonal influences, or\nabnormal menstrual cycles. Adult women with thinning hair were randomized to receive MPS (N = 30) or placebo (N = 30)\ntwice daily for 90 days. Digital images were obtained from a 4 cm2 area scalp target area. Each subjectÃ¢â?¬â?¢s hair was washed and\nshed hairs were collected and counted. After 90 days, these measures were repeated and subjects completed Quality of Life and\nSelf-Assessment Questionnaires. MPS-treated subjects achieved a significant increase in the number of terminal hairs within the\ntarget area (P < 0.0001) which was significantly greater than placebo (P < 0.0001). MPS use also resulted in significantly less hair\nshedding (P = 0.002) and higher total Self-Assessment (P = 0.006) and Quality of Life Questionnaires scores (P = 0.035). There\nwere no reported adverse events. MPS promotes hair growth and decreases hair loss in women suffering from temporary thinning\nhair. This trial is registered with ClinicalTrials.gov Identifier: NCT02297360....
Confluent and reticulated papillomatosis (CARP) is a rare keratinization disorder that presents with asymptomatic, reticulated
papules coalescing into plaques, which adversely affect, most often, young black persons. Minocycline is considered the drug of
choice, but it is not without its host of potential side effects, including drug hypersensitivity, drug-induced lupus/vasculitis/
hepatitis, blue-gray skin hyperpigmentation, acute eosinophilic pneumonia, pseudotumor cerebri, and vestibular instability,
among others. Alternatively, doxycycline might be considered as another first-line agent for CARP as it can effectively clear lesions
while offering a more favorable side effect profile in select patients. Herein, we present a case of CARP successfully resolved with
doxycycline after a protracted treatment history of topical and oral antifungal medications for suspected tinea versicolor (TV)....
Background: The impact of Malassezia yeasts on skin mycobiome and health has received considerable attention\nrecently. Pityriasis versicolor (PV), a common dermatosis caused by Malassezia genus worldwide, is a manifestation of\ndysbiosis. PV can be associated with hyper- and/or hypopigmented skin lesions. This disease entity is characterized\nby high percentage of relapses, which demands a proper antifungal therapy that is based on unambiguous species\nidentification and drug susceptibility testing.\nCase presentation: Comprehensive analysis of PV case in man presenting simultaneously hyper- and\nhypopigmented skin lesions was performed. Conventional and molecular diagnostic procedures revealed Malassezia\nfurfur and Malassezia sympodialis, respectively as etiological agents of skin lesions observed. Susceptibility tests\nshowed significantly lowered sensitivity of M. furfur cells to fluconazole. Based on susceptibility profiles local\nantifungal therapy with drugs characterized by entirely different mechanism of action was included.\nConclusions: Our study indicates that cases of PV represented by two types of skin lesions in one patient may be\nassociated with distinct Malassezia species. Moreover, as observed in this case, each of the isolated etiological\nagents of PV may differ significantly in susceptibility to antifungals. This can significantly complicate the treatment\nof dermatosis, which by definition is associated with a significant percentage of relapses. In the presented case\nlocalized topical treatment was sufficient and successful while allowing maintaining the physiological mycobiome....
Infection from Toxocara species may give rise to a large array of clinical symptoms, including apparentmanife stations of allergy such\nas asthma, urticaria/angioedema, and dermatitis.We report a case, thus far not described, of contact dermatitis attributed to nickel\nallergy but caused by Toxocara infection. The patient was a 53-year-old woman presenting from10 years a dermatitis affecting head,\nneck, and thorax. Patch tests initially performed gave a positive result to nickel, but avoidance of contact with nickel did not result\nin recovery.The patient referred to our Allergy Service in 2010 because of dermatitis to feet. Patch testing confirmed the positive\nresult for nickel, but expanding the investigation a positive result for IgG antibodies to Toxocara was detected by Western blotting\nand ELISA. Treatment with mebendazole achieved immediate efficacy on feet dermatitis. Then, two courses of treatment with\nalbendazole resulted in complete regression of dermatitis accompanied by development of negative ELISA and Western blotting\nfor Toxocara antibodies. This report adds another misleading presentation of Toxocara infection as apparent contact dermatitis\ncaused by nickel and suggests bearing in mind, in cases of contact dermatitis not responding to avoidance of the responsible hapten\nand to medical treatment, the possible causative role of Toxocara....
Basal cell carcinoma (BCC) is the most common skin tumor and contains several different histopathological types. Here, we report a case of cystic basal cell carcinoma, which is relatively rare and might be clinically misdiagnosed. A dermatoscopic examination of the case revealed a homogenous blue/black area usually not seen in BCC. We reviewed 102 BCC cases resected and diagnosed at Sapporo Medical University Hospital between April 2005 and March 2010. Among them, only three were the cystic type....
Leprosy is a common skin disease in Sri Lanka which is being increasingly diagnosed due to the existing successful public health\nprogramme. Dapsone is a drug which holds unique pharmacological properties where it serves as both anti-inflammatory and\nantimicrobial agents. Of its main adverse effects, agranulocytosis is a serious consequence which is reported mainly in adults and\nelderly. We report a 7-year-old child who sustained life-threatening skin and subcutaneous tissue sepsis because of dapsoneinduced\nagranulocytosis. Besides, this case highlights the importance of meticulous monitoring of cell counts due to the risk of\nneutropenia and the natural history of cell recovery following occurrence of neutropenia. )ough high mortality rate has been\ndescribed in most of the similar cases reported, the child we describe made a complete recovery following severe\nneutropenic sepsis....
Granuloma annulare (GA) is a benign inflammatory dermatosis characterized clinically by dermal papules and annular plaques.\nThe pathogenesis of GA is not well understood, although it is thought to result from a delayed-type hypersensitivity reaction in\nwhich inflammatory cells elicit connective tissue degradation. This condition has been seen following the use of several drugs,\nincluding tumor necrosis factor-alpha (TNF-...
Syphilis is a sexually transmitted disease caused by Treponema pallidum. The signs and symptoms of syphilis vary depending on\nwhich of the four stages it presents. The primary stage of syphilis classically presents with a painless ulcer (chancre). We report a\ncase of the extragenital chancre on the nipple which is examined from skin biopsy and immunohistochemistry. This case showed\nthat it is important to identify the special siteâ??s pruritus erythema by pathology and serological examination....
Prior to his initial diagnosis, a 21-year-old male had been experiencing facial
acne for two years and had been treated by a doctor in private practice. The
patient visited our department because the clinical manifestations of mandibular
acne did not improve. At the time of initial examination, telangiectasia
(TE), post-inflammatory erythema (PIE), post-inflammatory hyperpigmentation
(PIH), atrophic scars (ASs), and a hypertrophic scar (HS) with induration
were observed on the right neck. We diagnosed this as an acne vulgaris
complication. HS lesions were topically treated by injecting triamcinolone
acetonide, and the patient was prescribed 8.1 g/day of oral Saireito (Japanese
herb). Adapalene benzoyl peroxide gel and topical tacrolimus hydrate ointment
were used to treat PIE and TE. Both HSs and PIE improved; however,
TE and AS did not improve. Currently, the patient is under observation. We
consider this to be a very rare concurrent occurrence of diverse complications
of acne vulgaris, and present the following case study....
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