Frequency: Quarterly E- ISSN: 2347-2464 P- ISSN: Awaited Abstracted/ Indexed in: Ulrich's International Periodical Directory, Google Scholar, SCIRUS, getCITED
Quarterly published in print and online "Inventi Impact: Ophthalmology (Formerly Inventi Impact: Vision)" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal welcomes papers in all the areas of ophthalmology including vision and eye diseases like glaucoma, blindness, cataract, diabetic retinopathy.
Objective. To compare 18-fluorodeoxyglucose (FDG) uptake by positron emission tomography (PET) in extraocular muscles (EOMs) of patients with Graves'' ophthalmopathy (GO) versus patients without GO. Design. Prospective, observational, comparative, and cross-sectional study. Participants. Thirty-two eyes of patients with GO and seventy eyes of patients without GO. Methods. We prospectively included patients older than 18 years of age with and without GO. FDG-PET imaging study was performed; standardized unit value (SUVmax) was quantified in EOMs. Standard deviation and significant statistical difference (P < 0.05) were calculated. Results. Thirty-two eyes of sixteen patients of the GO group were included, with a mean age of 44.31 (20-71) years. Seventy eyes of thirty-five patients of the group without GO were included, with a mean age of 49.20 (24-77) years. EOMs average uptake of the groups with and without GO were 3.38 �± 1.31 and 1.89 �± 0.51 SUVmax (P < 0.05), respectively. Conclusion. FDG uptake was significantly increased in EOMs of patients with GO. PET gives valuable information and may be a helpful tool in detecting, localizing, and quantifying GO inflammation. Further research is needed to define the role of PET in detecting, grading, and following up GO in order to optimize treatment in the inflammatory stage....
Background: We sought to verify the efficacy and safety of transconjunctival 23-\ngauge pars plana vitrectomy (PPV) alone by our bimanual technique for the removal\nof dense posteriorly dislocated crystalline lens. Methods: A retrospective, noncomparative,\ninterventional study of 31 consecutive cases of patients who underwent\n23-gauge PPV alone for the removal of dense posteriorly dislocated crystalline lens\nfollowing complicated cataract surgeries using our bimanual technique was conducted.\nThe main outcomes measured included best-corrected visual acuity (BCVA),\npreoperative intraocular pressure (IOP), postoperative IOP and postoperative complications.\nResults: In all 31 cases included in this study, those dense posteriorly dislocated\ncrystalline lenses were successfully removed. The enrolled patients consisted\nof 17 males and 14 females with a mean age of (75.84 �± 6.17) years (range 59 - 90).\nThe mean follow-up length was (7.61 �± 1.87) months with a range of 6 months to 1\nyear. The mean preoperative BCVA was 0.22 �± 0.11 logMAR system, and the postoperative\nBCVA was 0.33 �± 0.07 logMAR system after 6 months of follow-up. The\nmean operative time was 46.32 �± 4.80 minutes with a range of 38.00 to 57.00 minutes.\nAll of the conjunctival incisions self-closed within the first week with no wound\nleakage or hemorrhage. The postoperative complications were relatively rare. Conclusions:\nThe removal of dense posteriorly dislocated crystalline lens might be a challenge\nfor micro-incision vitrectomy. Our bimanual technique was proved to be an effective\nand safe method for those particular dense lenses using 23-gauge alone....
Background: To investigate the surgical outcomes of implantable collamer lens (ICL) implantation in eyes with residual myopia after primary laser vision correction (LVC) surgeries. Methods: This study included patients who underwent ICL implantation and had a history of LVC surgery, including photorefractive keratectomy (PRK) or laser-assisted in situ keratomileusis (LASIK). Visual acuity and refractive error were assessed pre and 3-months postoperatively and the efficacy and safety indices calculated accordingly. Results: A total of 30 eyes of 17 patients were included in this study. At 3 months, the mean logMAR uncorrected distance visual acuity (UDVA), corrected distance visual acuity (CDVA), and spherical equivalent were − 0.03 ± 0.11 (include logMAR), − 0.04 ± 0.09 (include logMAR), and − 0.06 ± 0.33 diopters (D), respectively. The 3-month Snellen UDVA was better than 20/20 for 83% of eyes, and 97% of eyes showed an unchanged or improved CDVA after surgery. The mean efficacy and safety indices were 1.11 ± 0.22 and 1.13 ± 0.20, respectively. Further, 93 and 100% of eyes were within ±0.5 and ± 1.0 D of the attempted spherical equivalent refraction, respectively. Conclusions: ICL implantation in eyes with myopic regression after previous LVC surgery showed safe, effective, and predictable outcomes....
Background: Specific cross-reacting autoimmunity against recoverin or collapsin response mediator protein\r\n(CRMP)-5 is known to cause cancer-associated retinopathy or paraneoplastic optic neuropathy, respectively.\r\nWe report a rare case with small cell lung carcinoma developing bilateral neuroretinitis and unilateral focal outer\r\nretinitis positive for these antibodies.\r\nCase presentation: A 67-year-old man developed bilateral neuroretinitis and foveal exudation in the right eye.\r\nOptical coherence tomography showed a dome-shaped hyperreflective lesion extending from inner nuclear layer to\r\nthe photoreceptor layer at the fovea in the right eye. Single-flash electroretinography showed normal a-waves in\r\nboth eyes and slightly reduced b-wave in the left eye. Results of serological screening tests for infection were within\r\nnormal limits. The patient�s optic disc swelling and macular exudation rapidly improved after oral administration of\r\nprednisolone. Systemic screening detected lung small cell carcinoma and systemic chemotherapy was initiated.\r\nImmunoblot analyses using the patient�s serum detected autoantibodies against recoverin, CRMP-5, and a-enolase,\r\nbut not carbonic anhydrase II. Neuroretinitis once resolved after almost remission of carcinoma on imaging but it\r\nrecurred following the recurrence of carcinoma.\r\nConclusions: The development of neuroretinitis in this cancer patient with anti-retinal and anti-optic nerve\r\nantibodies depended largely on the cancer activity, suggesting the possible involvement of paraneoplastic\r\nmechanisms. Patients with paraneoplastic optic neuropathy and retinopathy are likely to develop autoimmune\r\nresponses against several antigens, thus leading to various ophthalmic involvements....
Background: To report a modified surgical technique for intrascleral intraocular lens (IOL) fixation with fewer\nanterior segment manipulations in eyes lacking sufficient capsular support.\nMethods: Eyes from 14 patients who underwent 27-gauge needle-guided intrascleral IOL fixation with built-in 8â??0\nabsorbable sutures were studied. The 8-0 absorbable sutures were inserted into 27-gauge round needles and used\nto create sclerotomies at the 4 oâ??clock and 10 oâ??clock positions under the scleral flap. The sutures were used to tie\nknots at the end of each haptic and guide haptic externalization through the sclerotomy. After externalization, a\nsufficient flange was created at the end of each haptic and fixed under the scleral flaps. The best corrected visual\nacuity (BCVA), corneal endothelial cell density (ECD), IOL tilt and decentration, previous surgery history, and\ncomplications were determined.\nResults: Fourteen cases were analyzed. The majority of eyes exhibited an improvement in the BCVA after surgery.\nWhen comparing the last follow-up to preoperative visual acuity, the mean change in BCVA was + 26.32 letters\n(p = 0.011). Postoperative complications included postoperative hypotony in 3 eyes, ocular hypertension in 2 eyes.\nNo cases of postoperative cystoid macular edema (CME), vitreous hemorrhage (VH), IOL dislocation, or\nendophthalmitis were observed.\nConclusions: The 27-gauge needle-guided intrascleral IOL fixation technique with built-in 8â??0 absorbable sutures is\neasy to perform with fewer anterior chamber manipulations and achieves both anatomical and optical stability....
Purpose: To compare the visual and refractive outcomes, patient satisfaction and spectacle independence\nbetween three novel designs of diffractive IOLs. Method: Prospective study including\n150 patients with implantation of three IOLs: trifocal diffractive IOL AT LISA tri 839 MP (ATLISA, n\n= 50), trifocal diffractive IOL PhysIOL FineVision (FineVision, n = 50) and the extended range of vision\nIOL Tecnis Symfony ZRX00 (Symfony, n = 50). Patients were followed up for 6 months after\nsurgery. Major parameters were monocular and binocular uncorrected (UDVA) and corrected\n(CDVA) distance, uncorrected (UIVA) and distance corrected (DCIVA) intermediate (80 cm), and\nuncorrected (UNVA) and distance corrected (DCNVA) near (40 cm) visual acuities (UNVA), contrast\nsensitivity (CS), defocus curve as well as patient satisfaction and spectacle use. Results: Mean\npostoperative decimal UDVA was 1.01 for Symfony, 0.96 for ATLISA and 0.95 for the FineVision\nIOL. Postoperative UIVA was 0.95 with Symfony, 0.72 with ATLISA and 0.85 with the FineVision\nIOL. Postoperative UNVA was 0.96 with the FineVision, 0.72 with the ATLISA and 0.63 with the\nSymfony IOL. The Symfony defocus curve showed the smoothest profile. Mean mesopic CS was 0.84\nlog units with the Symfony, 0.83 with the ATLISA (0.83) and 0.65 with the FineVision IOL. Mean\nphotopic CS with the Symfony, ATLISA and FineVision was 1.05, 0.85 and 0.69 log units, respectively.\nTwenty percent of the patients with the ATLISA and FineVision IOLs and 5.6% of the Symfony\npatients reported halos and glare as troublesome or disabling. Reading glasses were frequently\nused by 5.6% of the Symfony patients. All patients with the trifocal IOLs reported to be\nspectacle-free for any distance. Conclusion: All 3 IOLs produce excellent results with high levels of\nspectacle independence. The Symfony produces better levels of distance and intermediate visual\nacuity, whereas the trifocal IOLs produced better near vision. Higher frequency of dysphotopsia\nwas seen with the trifocal IOLs....
Autosomal dominant congenital stationary night blindness (adCSNB) is rare and results from altered phototransduction giving a\nRiggs type of electroretinogram (ERG) with loss of the rod a-wave and small b-waves. These patients usually have normal vision\nin light. Only few mutations in genes coding for proteins of the phototransduction cascade lead to this condition; most of these\ngene defects cause progressive rod-cone dystrophy. Mutation analysis of an adCSNB family with a Riggs-type ERG revealed a\nnovel variant (c.155T>A p.Ile52Asn) in GNAT1 coding for the ...
Background: To demonstrate that the Corvis ST could be used to quantify the biomechanical parameters of the\norbital soft tissues by measuring and comparing whole eye movement (WEM) using the Corvis in normal eyes and\nin eyes of patients with Graves ophthalmopathy.\nMethods: Forty four eyes of 44 ophthalmologically normal subjects and 28 eyes of 28 patients with Graves\nophthalmopathy were included in the study. After Corvis test, the examiners recorded WEM by air puff. In the patients\nwith Graves ophthalmopathy, the partial correlation coefficient adjusted for age and gender was calculated to analyze the\ncorrelation between exopthalmometry and WEM. Same analysis was repeated for the correlation between and the cross\nsectional area (%) of the extraocular muscles in the orbit CT and WEM.\nResult:..............
Riboflavin/UVA cross-linking is a technique introduced in the past decades for the treatment of keratoconus, keratectasia, and\ninfectious keratitis. Its efficacy and safety have been investigatedwith clinical and laboratory studies since its first clinical application\nby Wollensak for the treatment of keratoconus. Although its complications are encountered during clinical practice, such as\ninfection inducing risk, minimal invasion merits a further investigation on its future application in clinical practice. Recently,\ncollagen cross-linking in sclera shows a promising prospect. In present study, we summarized the representative studies describing\nthe clinical and laboratory application of collagen cross-linking published in past decades and provided our opinion on the positive\nand negative results of cross-linking in the treatment of ophthalmic disorders....
Background: Drainage of exudative retinal detachment may be necessary for either therapeutic or diagnostic\npurposes (or both). Here, we describe an external drainage technique for non-resolving vision-threatening\nexudative retinal detachment which combines the advantages of internal drainage (widefield viewing and\nintraocular pressure control using continuous anterior chamber infusion) with those of external drainage (drainage\nof sub-retinal fluid without vitrectomy).\nCase presentation: To illustrate this technique, we present a 13-year-old girl with macula-off exudative retinal\ndetachment secondary to Vogt-Koyanagi-Harada syndrome, which was unresponsive to aggressive medical\nmanagement.......................................
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