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Quarterly published in print and online "Inventi Impact: Oncology (Formerly Inventi Impact: Cancer)" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. This journal focuses on all the aspects of oncology including etiology, course, and treatments of cancer. Aimed at the broader audience the journal accomplishes the objectives by facilitating the transfer of knowledge from the laboratory to the bedside; by contributing to cancer prevention, early detection, diagnosis, cure, and rehabilitation.
Metastatic lung tumours rarely lead to development of pneumothorax, and\nno case of bilateral secondary pneumothorax due to lung metastases arising\nfrom tongue cancer has been reported. Here, we report a case of a patient\nwith tongue cancer with lung metastases complicated by bilateral secondary\npneumothorax soon after the completion of concurrent chemoradiotherapy.\nA 39-year-old man with cervical lymph node metastases originating from\npT2N0M0 tongue cancer underwent neck dissection and postoperative concurrent\nchemoradiotherapy. Shortly after the completion of chemoradiotherapy,\nhe developed bilateral secondary pneumothorax. Subsequently, he underwent\npartial lung resection for the pulmonary fistulae for diagnostic and\ntherapeutic purposes; nodular lesions found in both the lungs. The diagnosis\nof secondary pneumothorax was based on histopathological findings. Although\nall pulmonary fistulae disappeared after partial lung resection, he died\nof the primary disease despite our best efforts to control the metastatic pulmonary\nlesions....
We report a rare male case of an undifferentiated carcinoma with osteoclast-like giant cells originating in an indeterminate mucin-producing cystic neoplasm of the pancreas. A 59-year-old Japanese man with diabetes visited our hospital, complaining of fullness in the upper abdomen. A laboratory analysis revealed anemia (Hemoglobin; 9.7 g/dl) and elevated C-reactive protein (3.01 mg/dl). Carbohydrate antigen 19-9 was 274 U/ml and Carcinoembryonic antigen was 29.6 ng/ml. A computed tomography scan of the abdomen revealed a 14-cm cystic mass in the upper left quadrant of the abdomen that appeared to originate from the pancreatic tail. The patient underwent distal pancreatectomy/splenectomy/total gastrectomy/cholecystectomy. The mass consisted of a multilocular cystic lesion. Microscopically, the cyst was lined by cuboidal or columnar epithelium, including mucinous epithelium. Sarcomatous mononuclear cells and multinucleated osteoclast-like giant cells were found in the stroma. Ovarian-type stroma was not seen. We made a diagnosis of osteoclast-like giant cell tumor originating in an indeterminate mucin-producing cystic neoplasm of the pancreas. All surgical margins were negative, however, two peripancreatic lymph nodes were positive. The patient recovered uneventfully. Two months after the operation, multiple metastases occurred in the liver. He died 4 months after the operation....
Background: Gallbladder cancer (GBC) is a highly aggressive malignancy in elderly patients. Our goal is aimed to
construct a novel nomogram to predict cancer-specific survival (CSS) in elderly GBC patients.
Method: We extracted clinicopathological data of elderly GBC patients from the SEER database. We used univariate
and multivariate Cox proportional hazard regression analysis to select the independent risk factors of elderly GBC
patients. These risk factors were subsequently integrated to construct a predictive nomogram model. C-index, calibration
curve, and area under the receiver operating curve (AUC) were used to validate the accuracy and discrimination
of the predictive nomogram model. A decision analysis curve (DCA) was used to evaluate the clinical value of the
Result: A total of 4241 elderly GBC patients were enrolled. We randomly divided patients from 2004 to 2015 into
training cohort (n = 2237) and validation cohort (n = 1000), and patients from 2016 to 2018 as external validation
cohort (n = 1004). Univariate and multivariate Cox proportional hazard regression analysis found that age, tumor
histological grade, TNM stage, surgical method, chemotherapy, and tumor size were independent risk factors for the
prognosis of elderly GBC patients. All independent risk factors selected were integrated into the nomogram to predict
cancer-specific survival at 1-, 3-, and 5- years. In the training cohort, internal validation cohort, and external validation
cohort, the C-index of the nomogram was 0.763, 0.756, and 0.786, respectively. The calibration curves suggested that
the predicted value of the nomogram is highly consistent with the actual observed value. AUC also showed the high
authenticity of the prediction model. DCA manifested that the nomogram model had better prediction ability than
the conventional TNM staging system.
Conclusion: We constructed a predictive nomogram model to predict CSS in elderly GBC patients by integrating
independent risk factors. With relatively high accuracy and reliability, the nomogram can help clinicians predict the
prognosis of patients and make more rational clinical decisions....
Background: Pancreatic head adenocarcinoma (PHAC), a malignant tumour, has a very poor prognosis, and the
existing prognostic tools lack good predictive power. This study aimed to develop a better nomogram to predict
overall survival after resection of non-metastatic PHAC.
Methods: Patients with non-metastatic PHAC were collected from the Surveillance, Epidemiology, and End Results
(SEER) database and divided randomly into training and validation cohorts at a ratio of 7:3. Cox regression analysis
was used to screen prognostic factors and construct the nomogram. Net reclassification improvement (NRI) and
integrated discrimination improvement (IDI) were calculated to evaluate the performance of the model. The
predictive accuracy and clinical benefits of the nomogram were validated using the area under the curve (AUC),
calibration curves, and decision curve analysis (DCA).
Results: From 2010 to 2016, 6419 patients with non-metastatic PHAC who underwent surgery were collected from
the SEER database. A model including T stage, N stage, grade, radiotherapy, and chemotherapy was constructed.
The concordance index of the nomogram was 0.676, and the AUCs of the model assessing survival at multiple
timepoints within 60 months were significantly higher than those of the American Joint Committee on Cancer
(AJCC) 8th staging system in the training cohort. Calibration curves showed that the nomogram had ability to
predict the actual survival. The NRI, IDI, and DCA curves also indicated that our nomogram had higher predictive
capability and clinical utility than the AJCC staging system.
Conclusions: Our nomogram has an ability to predict overall survival after resection of non-metastatic PHAC and
includes prognostic factors that are easy to obtain in clinical practice. It would help assist clinicians to conduct
Concurrent dural and leptomeningeal metastatic carcinomatosis are very rare\nand have a poor prognosis. Here we present a woman with advanced estrogen\nreceptor (ER) positive and progesterone receptor (PR) positive breast cancer\nwho presented with leptomeningeal disease. Patient underwent multi targeted\nepigenetic therapies applied in a protocol called MTET. She continued to respond\nto the interval treatment, which consisted only of the nutraceutical\nagents. Here we discuss her case in detail and we believe that such an example\nmight be applied to other patients in this situation resulting clinical improvement\nand less toxicity....
Background: The aim of this study was to determine the proportions and predictors of first-degree relatives (FDRs)\r\nof colorectal cancer (CRC) patients (i) ever receiving any CRC testing and (ii) receiving CRC screening in accordance\r\nwith CRC screening guidelines.\r\nMethods: Colorectal cancer patients and their FDRs were recruited through the population-based Victorian Cancer\r\nRegistry, Victoria, Australia. Seven hundred and seven FDRs completed telephone interviews. Of these, 405 FDRs\r\nwere deemed asymptomatic and eligible for analysis.\r\nResults: Sixty-nine percent of FDRs had ever received any CRC testing. First-degree relatives of older age, those\r\nwith private health insurance, siblings and FDRs who had ever been asked about family history of CRC by a doctor\r\nwere significantly more likely than their counterparts to have ever received CRC testing. Twenty-five percent of\r\nFDRs Ã¢â?¬Å?at or slightly above average riskÃ¢â?¬Â were adherent to CRC screening guidelines. For this group, adherence to\r\nguideline-recommended screening was significantly more likely to occur for male FDRs and those with a higher\r\nlevel of education. For persons at Ã¢â?¬Å?moderately increased riskÃ¢â?¬Â and Ã¢â?¬Å?potentially high riskÃ¢â?¬Â, 47% and 49% respectively\r\nadhered to CRC screening guidelines. For this group, guideline-recommended screening was significantly more\r\nlikely to occur for FDRs who were living in metropolitan areas, siblings, those married or partnered and those ever\r\nasked about family history of CRC.\r\nConclusions: A significant level of non-compliance with screening guidelines was evident among FDRs. Improved\r\nCRC screening in accordance with guidelines and effective systematic interventions to increase screening rates\r\namong population groups experiencing inequality are needed....
Background: Most skin cancers are preventable by encouraging consistent use of sun protective behaviour. In\r\nAustralia, adolescents have high levels of knowledge and awareness of the risks of skin cancer but exhibit\r\nsignificantly lower sun protection behaviours than adults. There is limited research aimed at understanding why\r\npeople do or do not engage in sun protective behaviour, and an associated absence of theory-based interventions\r\nto improve sun safe behaviour. This paper presents the study protocol for a school-based intervention which aims\r\nto improve the sun safe behaviour of adolescents.\r\nMethods/design: Approximately 400 adolescents (aged 12-17 years) will be recruited through Queensland,\r\nAustralia public and private schools and randomized to the intervention (n = 200) or Ã¢â?¬Ë?wait-listÃ¢â?¬â?¢ control group (n =\r\n200). The intervention focuses on encouraging supportive sun protective attitudes and beliefs, fostering\r\nperceptions of normative support for sun protection behaviour, and increasing perceptions of control/self-efficacy\r\nover using sun protection. It will be delivered during three Ã?â?? one hour sessions over a three week period from a\r\ntrained facilitator during class time. Data will be collected one week pre-intervention (Time 1), and at one week\r\n(Time 2) and four weeks (Time 3) post-intervention. Primary outcomes are intentions to sun protect and sun\r\nprotection behaviour. Secondary outcomes include attitudes toward performing sun protective behaviours (i.e.,\r\nattitudes), perceptions of normative support to sun protect (i.e., subjective norms, group norms, and image norms),\r\nand perceived control over performing sun protective behaviours (i.e., perceived behavioural control).\r\nDiscussion: The study will provide valuable information about the effectiveness of the intervention in improving\r\nthe sun protective behaviour of adolescents....
A duck was received for necropsy with history of dullness, anorexia and distended abdomen. On postmortem examination, cystic and papillary growth are seen in the ovary. Histopathological examination revealed multi branched papillae in the cyst lumen. Based on gross and microscopic lesions, the case was diagnosed as cyst adenocarcinoma....
A duck was received for post-mortem examination with history of anorexia, dull, depressed and the carcass was emaciated with distended abdomen. On necropsy examination revealed a mass in the abdominal cavity, attached to the liver and mescentry of visceral organs and covered with dense fibrous tissue. The mass was dark red to reddish black in colour, firm in consistency, size ranges from 15-18 cms. Histopathological examination revealed variable sized vascular spaces and channels that are lined by flattend endothelium, vascular spaces filled with blood and plasma. Based on gross and histopathological examination the present case was diagnosed as haemangioma....
A 26-year-old male without any significant past medical history presented to the hospital with shortness of breath, cough, pleuritic\nchest pain, and weight loss for the past 3 months. On chest CT, he was found to have extensive mediastinal and hilar lymphadenopathy\nand multiple pulmonary nodules. On physical examination, a right groin mass was noted which had been slowly growing\nfor the past 2 years. Ultrasound of the groin showed complex solid mass with internal vascular channels. CT guided biopsy of the\nmass showed desmoplastic small round cell tumour. His hospital course was complicated by hypoxic respiratory failure requiring\nemergent intubation and ICU admission where he completed one cycle of vincristine, cyclophosphamide, and doxorubicin with\nsubsequent improvement, followed by extubation. His condition continued to improve after second cycle of chemotherapy and he\nwas ultimately discharged in a stable condition to continue outpatient chemotherapy after a 2-month inpatient stay....
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