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Quarterly published in print and online "Inventi Impact: Medicine (Formerly Inventi Impact: Holistic Medicines)" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal focuses on alternative healthcare systems having wholesome or holy approach towards the health and disease management. Articles are invited from such areas as Ayurveda, Unani, Tibb, Homeopathy, Chiropractic, Osteopathy, Naturopathy, Massage Therapy, Meditation, Acupuncture, Crystals, Natural Diet and Herbal or Home Remedies.
Background: Genetic and environmental factors especially climatic conditions are thought to influence the shape
and size of the paranasal sinuses and anatomic variations may create both a diagnostic and therapeutic challenge.
However, no study has been published about the climatic adaptation of the paranasal sinus region in different populations.
This study aimed to compare the prevalence of anatomical variants in the paranasal sinus and nasal cavity
using Cone-Beam Computed Tomography (CBCT) between Polish and Turkish Cypriot populations.
Methods: The material consisted of volumes acquired utilizing Galileos (Sirona, Germany) as well as Newtom 3G (QR
Verona, Newtom, Italy) CBCT units. There were examined 356 Polish and 359 Turkish Cypriot patients in whom paranasal
sinuses were included in the field of view. Paranasal sinus anatomic variations were assessed in both populations.
Results: In the Polish population, the most common anatomic variation was septum deviation followed by the
Agger nasi cell and concha bullosa with a prevalence of 87.7%, 83.2%, and 54.8% respectively. For the Turkish Cypriot
population, the most common anatomic variation was Agger nasi cell followed by concha bullosa and supraorbital
ethmoid cells with a prevalence of 81.6%, 68%, and 57.8% respectively. Many anatomic variations were found to show
substantial differences among both populations. Incidence rates of hyperpneumatization of the frontal sinus, septum
pneumatization, supraorbital ethmoid cells, concha bullosa, uncinate bulla, and internal carotid artery protrusion into
the sphenoid sinus were significantly higher in the Turkish Cypriot group, while the incidence of Haller cell, frontal
sinus hypoplasia, maxillary sinus hypoplasia, ethmomaxillary sinus, sphenomaxillary plate, and septum deviation were
significantly higher in Polish population.
Conclusion: According to the Köppen-Geiger world climatic map, the climate is warmer and drier in Turkish Cypriote
populations than in the Polish population. These climatic differences influence the paranasal sinus variations between
the Turkish Cypriot and Polish populations that must be taken into account by rhinologic surgeons especially when
performing frontal and sphenoid sinus surgery....
This study is to investigate the correlations among Sanjian (LI3), Hegu (LI4), and Yangxi (LI5) acupoints and their corresponding\nnonacupoints on the Yangming Large Intestine Meridian of Hand before and after laser irradiation using optical coherence\ntomography (OCT) and diffuse reflectance spectra. The experiment was conducted on 10 healthy people. A 658 nm laser with\n50mW output power was used for irradiating LI4, LI5 acupoints and their corresponding nonacupoints. As to LI4 acupoint with\nlaser irradiation for duration of 15 or 45 minutes, the OCT backscattered light intensities of LI4 and LI5 acupoints increased\nsignificantly, and the reflectance intensities (RIs) of the LI3, LI4, and LI5 acupoints decreased significantly. As to LI5 acupoint\nwith laser irradiation for duration of 15 or 45 minutes, the changes of OCT backscattered light intensities of the corresponding\nirradiated acupoint and LI4 acupoint increased significantly, and the RIs decreased significantly. However, the OCT backscattered\nlight intensities and RIs for their nonacupoints were almost not changed. The results show that an association exists between two\nadjacent same-meridian acupoints on the same meridian after laser-needle acupuncture to some extent....
Diabetes mellitus represents a major burden in Saudi Arabia where seven million (20% of population) are living with diabetes. This\narticle reviews the literature on usage of traditional and complementary medicine (T&CM;) therapies among Saudi diabetic\npatients, focusing in particular on identifying the prevalence as well as discussing their safety and efficacy. Three databases\n(PubMed, Cochrane, and ScienceDirect) were searched prior to December 10, 2017, for articles published in peer-reviewed\njournals that reported primary data on the use of traditional and complementary medicine therapies among diabetic patients in\nSaudi Arabia. Six studies were selected according to the inclusion/exclusion criteria. In conclusion, the prevalence of use of T&CM;\ntherapies among diabetics in Saudi Arabia was 32.18%. This review identified that the most used T&CM; therapy among diabetics\nwas herbal treatment. The most used herbs were fenugreek, black seeds, neem, myrrh, helteet, harmel, and aloes. There is\ninsufficient or little evidence to support the efficacy of the most identified herbs and therapies. This review is raising the safety\nconcerns about the used herbs and complementary therapies which were commonly used without any medical consultation....
Objective. We sought to demonstrate that maca root may be an effective treatment for antidepressant-induced sexual dysfunction\n(AISD) in women. Method. We conducted a 12-week, double-blind, placebo-controlled trial of maca root (3.0 g/day) in 45 female\noutpatients (mean age of 41.5 Ã?Â± 12.5 years) with SSRI/SNRI-induced sexual dysfunction whose depression remitted. Endpoints were\nimprovement in sexual functioning as per the Arizona Sexual Experience Scale (ASEX) and the Massachusetts General Hospital\nSexual Function Questionnaire (MGH-SFQ). Results. 45 of 57 consented females were randomized, and 42 (30 premenopausal and\n12 postmenopausal women) were eligible for a modified intent-to-treat analysis based on having had at least one postmedication\nvisit. Remission rates by the end of treatmentwere higher for the maca than the placebo group, based on attainment of anASEX total\nscore ? 10 (9.5% for maca versus 4.8% for placebo), attaining an MGH-SFQ score ? 12 (30.0% for maca versus 20.0% for placebo)\nand reaching anMGH-SFQ score ? 8 (9.5% for maca versus 5.0% for placebo). Higher remission rates for the maca versus placebo\ngroup were associated with postmenopausal status. Maca was well tolerated. Conclusion. Maca root may alleviate SSRI-induced\nsexual dysfunction in postmenopausal women. This trial is registered with NCT00568126....
To investigate the acupuncture sensations elicited by the Japanese style of acupuncture, penetrating acupuncture and skin-touch\nplacebo needles were randomly administered at various insertion depths (5 and 10mm for the penetrating needles and 1 and\n2mm for the placebo needles) at LI4 to 50 healthy subjects. Among the 12 acupuncture sensations in the Massachusetts General\nHospital Acupuncture Sensation Scale (MASS), Ã¢â?¬Å?heavinessÃ¢â?¬Â was the strongest and most frequently reported sensation with the\n10mmneedles, but not with the 5mmneedles. There were no significant differences in number of sensations elicited,MASS index,\nrange of spreading, and intensity of needle pain for 5mm penetration versus 1mm skin press and 10mm penetration versus 2mm\nskin press. The MASS index with 2mm skin-touch needles was significantly larger than that with 1mm skin-touch and 5mm\npenetrating needles. The factor structures in the 12 acupuncture sensations between penetrating and skin-touch needles were\ndifferent. The acupuncture sensations obtained in this study under satisfactorily performed double-blind (practitionerÃ¢â?¬â??patient)\nconditions suggest that a slight difference in insertion depth and skin press causes significant differences in quantity and quality of\nacupuncture sensations....
Diverse and significant benefits against cold/flu symptoms and seasonal allergies have been observed with a dried fermentate\n(DF) derived from Saccharomyces cerevisiae (EpiCor) in multiple published randomized trials. To determine if DF may influence\nother immune conditions, two separate animal studies were conducted. Study 1 examined the ability of DF to prevent or reduce\ninflammation when given orally for 14 days to rats prior to receiving 1% carrageenan (localized inflammation model). DF\nsignificantly (P < 0.05) reduced swelling at all time points (1, 2, 3, 6, 12, and 24 hours) versus the control. Edema severity and PGE2\nlevels were reduced by approximately 50% and 25% (P < 0.05), respectively. Study 2 examined the ability of DF to treat established\ninflammation induced by type-2 collagen in mice over 4 weeks (autoimmune arthritis model). Significantly reduced arthritis\nscores, antibody response to type-2 collagen, and interferon-gamma levels were observed compared to controls (all parameters\nP < 0.05). DF favorably impacts multiple acute and potentially chronic immunologic inflammatory control mechanisms and\nshould be further tested in clinical trials....
This study protocol aims to explore the effectiveness, safety, and cost-effectiveness of a herbal medication, Gongjindan (GJD), in\npatients with chronic dizziness. This will be a prospective, multicenter, randomized, double-blind, placebo-controlled, parallelgroup,\nclinical trial. Seventy-eight patients diagnosed with MeniereÃ¢â?¬â?¢s disease, psychogenic dizziness, or dizziness of unknown\ncause will be randomized and allocated to either a GJD or a placebo group in a 1 : 1 ratio. Participants will be orally given 3.75 g\nGJD or placebo in pill form once a day for 56 days. The primary outcome measure will be the Dizziness Handicap Inventory\nscore. Secondary outcome measures will be as follows: severity (mean vertigo scale and visual analogue scale) and frequency\nof dizziness, balance function (Berg Balance Scale), fatigue (Fatigue Severity Scale) and deficiency pattern/syndrome (qi blood\nyin yang-deficiency questionnaire) levels, and depression (Korean version of BeckÃ¢â?¬â?¢s Depression Inventory) and anxiety (State-\nTrait Anxiety Inventory) levels. To assess safety, adverse events, including laboratory test results, will be monitored. Further, the\nincremental cost-effectiveness ratio will be calculated based on quality-adjusted life years (from the EuroQoL five dimensionsÃ¢â?¬â?¢\nquestionnaire) and medical expenses. Data will be statistically analyzed at a significance level of 0.05 (two-sided). This trial is\nregistered with ClinicalTrials.gov NCT03219515, in July 2017....
Objective: Post-stroke depression (PSD) is common and has a negative impact on recovery.\nAlthough many stroke patients in Taiwan have used acupuncture as a supplementary treatment for\nreducing stroke comorbidities, little research has been done on the use of acupuncture to prevent\nPSD. Accordingly, our goal is to investigate whether using acupuncture after a stroke can reduce\nthe risk of PSD. Method: This population-based cohort study examined medical claims data from a\nrandom sample of 1 million insured people registered in Taiwan. Newly diagnosed stroke patients\nin the period 2000Ã¢â?¬â??2005 were recruited in our study. All patients were followed through to the end\nof 2007 to determine whether they had developed symptoms of depression. A Cox proportional\nhazard model was used to estimate the relative risk of depression in patients after being diagnosed\nas having had a stroke, with a focus on the differences in those with and without acupuncture\ntreatment. Results: A total of 8487 newly-diagnosed stroke patients were included in our study; of\nthese, 1036 patients received acupuncture more than five times following their stroke, 1053 patients\nreceived acupuncture 1Ã¢â?¬â??5 times following their stroke and 6398 did not receive acupuncture. After we\ncontrolled for potential confounders (e.g., age, sex, insurance premium, residential area, type of stroke,\nlength of hospital stay, stroke severity index, rehabilitation and major illnessÃ¢â?¬â??related depression),\nwe found that acupuncture after stroke significantly reduced the risk of depression, with a hazard\nratio (HR) of 0.475 (95% CI, 0.389Ã¢â?¬â??0.580) in frequent acupuncture users and 0.718 (95% CI, 0.612Ã¢â?¬â??0.842)\nin infrequent acupuncture users, indicating that acupuncture may lower the risk of PSD by an\nestimated 52.5% in frequent users and 28.2% in infrequent users. Conclusions: After we controlled for\npotential confounders, it appears that using acupuncture after a stroke lowers the risk of depression.\nAdditional strictly-designed randomized controlled trials are needed to better understand the specific\nmechanisms relating acupuncture to health outcomes....
Background: People-centered tuberculosis (TB) care promotes treatment adherence
and outcomes. TB patients’ and families’ health education and protection
of their rights are among the core components of people-centered care.
We aimed to assess the level of people-centeredness of TB care as a proxy to
quality in the largest inpatient unit of the National Pulmonology Center (NPC)
in Armenia. Methods: We conducted a qualitative study by interviewing clinical
and administrative staff, TB patients, and family members to learn their
experiences about patient and family education and rights (PFE&R) protection
practices focusing on two Joint Commission International (JCI) Standards
for Hospital Accreditation. Mixed-conventional inductive and directed
deductive content approach guided the analysis of data. Results: The study
revealed various gaps in the provided services. According to the TB physicians
and nurses, they routinely educated patients and families and took actions to
protect their rights. However, practices reported by TB providers varied across
clinical departments and professionals and did not meet the recommendations
of the JCI standards. The document review revealed that no written policies
or procedures existed in the NPC inpatient unit to guide the implementation
of PFE&R. Lastly, patients’ inconsistent experiences were also indicative of the
lack of standardization and issues with PFE&R implementation. Conclusion:
Bridging the gap between existing and recommended practices by establishing
and enforcing new people-centered policies and procedures is a pledge for
improving operations and patients’ experiences with a potential nationwide impact
Background: About 90 % of patients with intra-thoracic malignancy experience breathlessness. Breathing training is\nhelpful, but it is unknown whether repeated sessions are needed. The present study aims to test whether three\nsessions are better than one for breathlessness in this population.\nMethods: This is a multi-centre randomised controlled non-blinded parallel arm trial. Participants were allocated to\nthree sessions or single (1:2 ratio) using central computer-generated block randomisation by an independent Trials\nUnit and stratified for centre. The setting was respiratory, oncology or palliative care clinics at eight UK centres.\nInclusion criteria were people with intrathoracic cancer and refractory breathlessness, expected prognosis Ã¢â?°Â¥3\nmonths, and no prior experience of breathing training. The trial intervention was a complex breathlessness\nintervention (breathing training, anxiety management, relaxation, pacing, and prioritisation) delivered over three\nhour-long sessions at weekly intervals, or during a single hour-long session. The main primary outcome was worst\nbreathlessness over the previous 24 hours (Ã¢â?¬Ë?worstÃ¢â?¬â?¢), by numerical rating scale (0 = none; 10 = worst imaginable).\nOur primary analysis was area under the curve (AUC) Ã¢â?¬Ë?worstÃ¢â?¬â?¢ from baseline to 4 weeks. All analyses were by\nintention to treat.\nResults: Between April 2011 and October 2013, 156 consenting participants were randomised (52 three; 104 single).\nOverall, the Ã¢â?¬Ë?worstÃ¢â?¬â?¢ score reduced from 6.81 (SD, 1.89) to 5.84 (2.39). Primary analysis [n = 124 (79 %)], showed no\nbetween-arm difference in the AUC: three sessions 22.86 (7.12) vs single session 22.58 (7.10); P value = 0.83); mean\ndifference 0.2, 95 % CIs (Ã¢â?¬â??2.31 to 2.97). Complete case analysis showed a non-significant reduction in QALYs with\nthree sessions (mean difference Ã¢â?¬â??0.006, 95 % CIs Ã¢â?¬â??0.018 to 0.006). Sensitivity analyses found similar results. The\nprobability of the single session being cost-effective (threshold value of Ã?Â£20,000 per QALY) was over 80 %.\nConclusions: There was no evidence that three sessions conferred additional benefits, including cost-effectiveness,\nover one. A single session of breathing training seems appropriate and minimises patient burden....
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