IBI Factor: 3.8, Global Impact Factor 0.78
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Quarterly published in print and online "Inventi Impact: Clinical Research" publishes high quality unpublished as well as high impact pre-published research and reviews catering to the needs of researchers and professionals. The journal covers all the areas of clinical pharmacy. It welcomes articles pertaining to rational therapeutics; evidence-based practices; safety, cost-effectiveness and clinical efficacy of drugs; drug interactions; clinical impact of drug formulations; pharmacogenetics; personalised, stratified and translational medicine; and, clinical pharmacokinetics etc.
To explore variation in relationship between VIQ and psychopathologies before and after treatment. In 46 cases of acute schizophrenic Indian subjects diagnosed on ICD-10/DSM IV TR criteria were measured on SANS (Scale for Assessment of Negative Symptoms), SAPS (Scale for Assessment of Positive symptoms) and WAIS-R (Indian adaptation) Wechsler’s Adult Intelligence scale-Revised before and after treatment. The result showed persistent negative relationship between the verbal intelligence and psychopathologies was maintained pre and post treatment throughout the study. But different respondents such as attention-impairment, delusion bizarre behavior and SAPS (total) had insignificant negative relationship. The formal thought disorder changed from negative to positive after treatment....
Keratitis is a condition in which the cornea of the eye becomes inflamed. It is caused by Bacteria, Viruses, Fungi and Parasites. This study investigate that the evaluation the clinical isolates and microbial diagnosis of keratitis causing microorganism using 16SrDNA and 18SrDNA gene sequencing for bacteria and fungi from infectious eye sample of keratitis patients. All keratitis subjects were examined with a slit lamp biomicroscope in the Eye Clinic of the General Hospital of Tiruchirappalli. The Bacteria and fungus were isolated in eye swabs of keratitis patients. The bacterial and fungal genes were sequenced by using 16S rRNA and 18S rRNA- PCR. These sequences were identified using BLASTn (Basic Local Alignment Search Tool nucleotide) and deposited in the GenBank (NCBI) with the accession numbers Staphylococcus aureus (JN378392), Staphylococcus epidermidis (HQ404365), Micrococcus sp.(HM20450), Streptococcus viridians(JN378393), Moraxella sp.(JQ039348), Propionibacterium acnes (JQ039349), Acinetobacter baumanii (JN652129), Citrobacter koseri (JN652127), Pseudomonas aeruginosa(JQ039350), Klebsiella sp.(JN652128) and flavobacterium (JN835368) whereas fungal genes such as Fusarium sp.(JQ412816), Candida albicans (JX912562), Aspergillus sp.(JX204747), Sebipora aquosa (submitted) Byssochlamys nivea (Submitted). Eleven bacterial strains and five fungal strains were identified and the results in our study may be useful for further research about molecular characterizing studies....
Two major trends have developed in pediatric bioethics: family-centered care and increased recognition of emerging\r\nautonomy through legal and policy entrenched rights. The different foci of their corresponding health care delivery\r\nmodels (Ã¢â?¬Å?family-centeredÃ¢â?¬Â or Ã¢â?¬Å?patient-/child-centeredÃ¢â?¬Â) create the potential for conflict in the context of seeking consent\r\nto research or, as will be presented, the possibility of integration. Given the state of current bioethical principles and\r\nlegal holdings, the pediatric patient should ultimately be the primary focus of ethical consideration and, at least in the\r\ncontext of dissenting to research, the childÃ¢â?¬â?¢s autonomous wishes should reign. However, in recognizing and supporting\r\na childÃ¢â?¬â?¢s emerging autonomy, the family context should also be respected and taken into account. This discussion\r\narticulates the values underpinning these two important trends in pediatric health care delivery, and proposes a model\r\nfor obtaining consent for pediatric research in the current context....
Psoriasis is a chronic inflammatory dermatitis disease that manifests on the skin, affecting 2-3% of the population. Many treatments are available, none is universally safe and effective. Therefore, there is need to prepare polyherbal formulations to provide safe and effective treatment with lesser side effects. The present study was conducted to assess the efficacy and safety of poly herbal formulations, Psoriasis Tablet and Oil, in patients with mild to moderate psoriasis. This was 3 months, open-labeled study of psoriasis tablets and oil in 20 patients suffering from mild to moderate psoriasis. Patients received 2 tablets thrice daily for 3 months and Oil to be applied over the affected area twice daily for 3 months. The efficacy was evaluated on the basis of parameters of psoriasis area severity index (PASI) and physician’s and patient’s global evaluation at follow- up visits. Twenty patients completed the study with reduction in symptoms of psoriasis to varying degrees. At end of month 1, 2 and 3, mean score of itching had a reduction 30.43, 58.69 and 80.43% and mean score of erythema had a fall of 25, 63.33 and 81.66% and mean score of scaling had a fall of 28.57, 67.85 and 83.93% and mean score of thickness had a fall of 28.79, 53.03 and 65.15% respectively. Global assessment by the physicians and patients indicated slight to cleared response. This study confirms the efficacy and safety of psoriasis tablets and oil in Indian patients with mild to moderate psoriasis....
Carbamazepine is known to produce the side effect of euphoria. As such, it lends itself to being a drug of abuse, particularly in\nthe adolescent population. This retrospective study evaluated carbamazepine abuse, treatment course, and associated morbidity\nin Chinese adolescents. The median dose of carbamazepine resulting in overdose was 2,000mg (800Ã¢â?¬â??5,000). Patients were largely\nfrom urban-rural fringe areas (76.47%, 52.94%) with school performance within the last 1/3 range and (52.94%) unsupervised by\nparents. 35.29% experienced an obvious sense of euphoria. All patients had nervous system symptoms, 6 (35.29%) cases developed\ncoma (GCS < 8), and 5 (29.41%) cases experienced convulsion. Four cases were treated with hemodialysis. The incidence rate in\nyoung patients with repeat carbamazepine use and without the supervision of parents was higher than that in first-time users (5/7\nversus 4/10), but the difference was not significant.The toxic dose of repeat users was 3428 Ã?Â± 1035mg, significantly higher than that\nof 1470 Ã?Â± 646mg in first-time users (...
Background: Increased antibiotic resistance is one of the major factors contributing to the
failure of H. pylori eradication. This study aimed to compare the efficacy and safety of doxycycline
and amoxicillin, both critical components for bismuth-based quadruple therapy, for the first-line
treatment of H. pylori-infected duodenal ulcers. Methods: An open, randomized case-controlled,
multicenter trial was conducted in seven hospitals in China. A total of 184 eligible participants
were divided into an IDFB (ilaprazole 5 mg, doxycycline 100 mg, furazolidone 100 mg, and bismuth
220 mg bid) or IAFB (ilaprazole 5 mg, amoxicillin 1000 mg, furazolidone 100 mg, and bismuth
220 mg bid) group for 14 days. Both groups were administrated with ilaprazole 5 mg qd for another
14 days. The main outcome was an H. pylori eradication rate; secondary outcomes were ulcer healing,
relief of symptoms, and incidence of adverse effects. Results: The H. pylori eradication rates were
85.9% (95% CI 78.6–93.9) in the IDFB vs. 84.8% (95% CI 77.3–92.3) in the IAFB group in ITT analysis
(p > 0.05), and 92.9% (95% CI 87.4–98.5) vs. and 91.8% (95% CI 85.8–97.7) in PP analysis (p > 0.05).
The overall ulcer healing rates of IDFB and IAFB were 79.1% and 84.7% (p > 0.05), both effective in
relieving symptoms. Only nine participants had adverse reactions in this trial (4/92 in IDFB and
5/92 in IAFB). Conclusion: A bismuth quadruple regimen containing doxycycline or amoxicillin
could be an effective and safe treatment for H. pylori eradication, while doxycycline replacement is an
alternative for participants with penicillin allergy....
Metabolic urate production is the result of purine catabolism, and increase in uric acid is primarily a manifestation of increase purine catabolism once other causes are excluded. The source of purine synthesis is glucose – 6 – phosphate of HMP shunt pathway, synthesized by glucose – 6 – phosphate dehydrogenase enzyme. But a valid study depicting state of this relationship in hyperuricemia is lacking. Also allupurinol the most widely used drug in hyperuricemia may indirectly effect the enzyme activity of glucose – 6 – phosphate dehydrogenase. So the study was conducted to verify the association of carbohydrate and nucleotide metabolism in state of hyperuricemia and effect of treatment with allupurinol on this relationship. The study very effectively proves this relationship (p<<0.001) and also shows a significant effect (p<<0.001) of allupurinol treatment on the activity of enzyme glucose – 6 – phosphate dehydrogenase....
This study evaluated the effects of alpha-s1 casein hydrolysate (ACH; LactiumÂ®) on the\nsubjective and objective sleep profiles of a community-based sample of Koreans with poor sleep quality.\nWe performed a double-blind, randomized crossover trial with 48 participants (49.0 ....add/subs 1.7 years old,\n65% female) who exhibited a mild to moderate degree of sleep disturbance. Either ACH or placebo\nwas administered for the initial four weeks, and the counterpart was administered in precisely the\nsame manner after a four-week washout period. Sleep disturbance scales, daytime functioning,\nand psychiatric aspects showed a similar tendency to improve during both ACH and placebo\nphases without significant group differences. Overall perceived sleep profiles in sleep diaries were\nsignificantly improved during the ACH phase, represented by increased total sleep time and sleep\nefficiency (SE), as well as decreased sleep latency and wake after sleep onset (WASO). Interestingly,\nactigraphy demonstrated significantly increased SE after continuous use of ACH for four weeks,\nclearly more improved when compared to two weeks of use. The polysomnography measures\nshowed a similar tendency without statistically significant group diffierences. Our findings suggest\nthat refined ACH was well tolerated and could improve sleep quality, with possible cumulative\nbeneficial effects with long-term administration....
Background: To better evaluate and improve the efficacy of dendritic cell (DC)-based cancer immunotherapy,\nwe conducted a clinical study of patients with advanced colorectal cancer using carcinoembryonic antigen\n(CEA)-pulsed DCs mixed with tetanus toxoid and subsequent interleukin-2 treatment. The tetanus toxoid in\nthe vaccine preparation serves as an adjuvant and provides a non-tumor specific immune response to enhance vaccine\nefficacy. The aims of this study were to (1) evaluate the toxicity of this treatment, (2) observe the clinical responses of\nvaccinated patients, and (3) investigate the immune responses of patients against CEA before and after treatment.\nMethods: Twelve patients were recruited and treated in this phase I clinical study. These patients all had metastatic\ncolorectal cancer and failed standard chemotherapy. We first subcutaneously immunized patients with metastatic\ncolorectal cancer with 1 Ã?â?? 106 CEA-pulsed DCs mixed with tetanus toxoid as an adjuvant. Patients received 3 successive\ninjections with 1 Ã?â?? 106 CEA-pulsed DCs alone. Low-dose interleukin-2 was administered subcutaneously following the\nfinal DC vaccination to boost the growth of T cells. Patients were evaluated for adverse event and clinical\nstatus. Blood samples collected before, during, and after treatment were analyzed for T cell proliferation\nresponses against CEA.\nResults: No severe treatment-related side effects or toxicity was observed in patients who received the regular 4 DC\nvaccine injections. Two patients had stable disease and 10 patients showed disease progression. A statistically\nsignificant increase in proliferation against CEA by T cells collected after vaccination was observed in 2 of 9 patients.\nConclusions: The results of this study indicate that it is feasible and safe to treat colorectal cancer patients using this\nprotocol. An increase in the anti-CEA immune response and a clinical benefit was observed in a small fraction of\npatients. This treatment protocol should be further evaluated in additional colorectal cancer patients with modifications\nto enhance T cell responses....
Background: Inhibition of interleukin (IL)-13, a Type 2 inflammatory mediator in asthma, improves lung function\nand reduces exacerbations; however, more effective therapies are needed. A subset of asthma patients also exhibits\nelevated IL-17, which is associated with greater disease severity, neutrophilic inflammation, and steroid resistance.\nBITS7201A is a novel, humanized bispecific antibody that binds and neutralizes both IL-13 and IL-17.\nMethods: Safety, pharmacokinetics, and immunogenicity of BITS7201A were evaluated in a phase 1 study. Part A\nwas a single ascending-dose design with 5 cohorts: 30-, 90-, and 300-mg subcutaneous (SC), and 300- and 750-mg\nintravenous (IV). Part B was a multiple ascending-dose design with 3 cohorts: 150-, 300-, and 600-mg SC every 4\nweeks Ã? 3 doses. Both parts enrolled approximately 8 healthy volunteers into each cohort (6 active: 2 placebo). Part\nB included an additional cohort of patients with mild asthma (600-mg SC).\nResults: Forty-one subjects (31 active, 10 placebo) and 26 subjects (20 active, 6 placebo) were enrolled into Parts A\nand B, respectively. The cohort with mild asthma patients was terminated after enrollment of a single patient. No\ndeaths, serious adverse events, or dose-limiting adverse events occurred. In Part A, 12 active (39%) and 5 placebo\nsubjects (50%), and in Part B, 6 active (30%) and 3 placebo subjects (50%) experienced at least 1 treatmentemergent\nadverse event (TEAE). The most common AEs were fatigue (n = 3) and influenza-like illness (n = 2). One\ninjection-site reaction was reported. Two subjects with elevated blood eosinophil counts at baseline had\ntransient elevations in blood eosinophilsâ?¦â?¦â?¦â?¦...
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