Current Issue : April - June Volume : 2013 Issue Number : 2 Articles : 5 Articles
This study was undertaken to explore gum from Bombax buonopozense calyxes\r\nas a binding agent in formulation of immediate release dosage forms using wet granulation\r\nmethod. The granules were characterized to assess the flow and compression properties\r\nand when compressed, non-compendial and compendial tests were undertaken to assess the\r\ntablet properties for tablets prepared with bombax gum in comparison with those prepared\r\nwith tragacanth and acacia gums. Granules prepared with bombax exhibited good flow and\r\ncompressible properties with angle of repose 28.60�°, Carrâ��s compressibility of 21.30% and\r\nHausnerâ��s quotient of 1.27. The tablets were hard, but did not disintegrate after one hour.\r\nFurthermore, only 52.5% of paracetamol was released after one hour. The drug release\r\nprofile followed zero order kinetics. Tablets prepared with bombax gum have the potential\r\nto deliver drugs in a controlled manner over a prolonged period at a constant rate....
The most commonly used of route of drug administration is oral route. But pediatric and geriatric patients have difficulty in swallowing or chewing solid dosage forms. Fast dissolving dosage forms finds their application in pediatric and geriatric patients due to ease of administration which requires no water for administration and also offers rapid onset of action, improved bioavailability. The present work was aimed at preparing a novel superdisintegrant in the formulation of fast dissolving tablets, though several superdisintegrants are available, there is continous need of investigationg new superdidntegrants which are cost effective and safe and also optimizing the concentration new superdisintegrant (starch butyrate) in the formulation of fast dissolving tablets by using 23 – factorial design....
The oral drug delivery has more attention among the different routes of drug administration. Regretfully, the variability of gastrointestinal physiology same as gastric emptying time, pH and agitation to cause an unpredictable bioavailability and lack of drug effectiveness. Prolongation of gastric time with sustained release systems leads to reduction the number of dosage regimen and improvement of drug bioavailability. Ranitidine is histamine H2 antagonist widely used in the treatment of gastric ulcer. It is suitable drug for gastroretentive floating granules due to its short half life and poor absorption in lower gastro intestinal tract. In the present research work, D-optimal design was used for optimization of levels of independent variables (sodium bicarbonate, beeswax, ethyl cellulose & citric acid) on dependent variables t50 and time taken for 100 % release in the formulations of ranitidine gastroretentive floating garnules with less experimentation. From the results it was concluded that sodium bicarbonate (10 %), beeswax (20 %) and ethyl cellulose (10 %) and citric acid (0 %) were favorable for formulation of gastroretentive floating granules employing vee gum as release retardant....
Orodispersible tablets also known as fast dissolving tablets disintegrate instantaneously within the mouth and thus can be consumed without water. The present study was aimed to formulate orodispersible tablets of Granisetron HCl by using Indion 234s disintegrant as it is efficient disintegrant in low concentration which is equally efficiently with hydrophilic and hydrophobic formulations, especially with the latter where the conventional disintegrants are ineffective. Orodispersible tablets were formulated by using conventional disintegrants and Indion 234s. Indion 234s was characterized for powder flow properties (bulk density, tapped density, Carr's consolidation index, Hausner ratio, angle of repose), swelling index, viscosity, pH, and loss on drying. The prepared tablets were evaluated for different tablet parametric tests, wetting time, water absorption ratio, effective pore radius, porosity, packing fraction, in-vitro and in-vivo disintegration time, in-vitro dissolution and stability studies. From the results, it could be concluded that Indion 234s could be used as disintegrant in the formulation of orodispersible tablets....
The objective of the present investigation is to formulate gastro retentive floating drug delivery systems (GRFDDS)\r\nof propranolol HCl by central composite design and to study the effect of formulation variables on floating lag\r\ntime, D1hr (% drug release at 1 hr) and t90 (time required to release 90% of the drug). 3 factor central composite\r\ndesign was employed for the development of GRFDDS containing novel semi synthetic polymer carboxymethyl\r\nethyl cellulose (CMEC) as a release retarding polymer. CMEC, sodium bicarbonate and Povidone concentrations\r\nwere included as independent variables. The tablets were prepared by direct compression method and were\r\nevaluated for in vitro buoyancy and dissolution studies. From the polynomial model fitting statistical analysis, it was\r\nconfirmed that the response floating lag time and D1hr is suggested to quadratic model and t90 is suggested to\r\nlinear model. All the statistical formulations followed first order rate kinetics with non-Fickian diffusion mechanism.\r\nThe desirability function was used to optimize the response variables, each having a different target, and the\r\nobserved responses were highly agreed with experimental values. Statistically optimized formulation was\r\ncharacterized by FTIR and DSC studies and found no interactions between drug and polymer. The results\r\ndemonstrate the feasibility of the model in the development of GRFDDS containing a propranolol HCl. Statistically\r\noptimized formulation was evaluated for in vivo buoyancy studies in healthy humans for both fed and fasted\r\nstates. From the results, it was concluded that gastric residence time of the floating tablets were enhanced at fed\r\nstage but not in fasted state...
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