Current Issue : October - December Volume : 2013 Issue Number : 4 Articles : 5 Articles
Chitosan is widely used polymer for controlled and sustained release drug delivery system. Chitosan is a deacetylated derivative of chitin, which produce chitosan by deacetylation on treatment with alkali. Chitoan is the second most abundant polysaccharides after cellulose. Chitosan is widely used in different fields like industry, cosmetics, medicine etc. Chitosan can be modified by either chemically or enzymaically. Modified derivatives of chitosan have shown good sustained and controlled release drug delivery. Modified chitosan has many advantages over ordinary chitosan such as higher aqueous solubility, mucoadhesive strength, intestinal permeability or higher absorption of neutral & cationic peptides analogue over wide range of pH. Chitosan has also shown many applications in various targeted drug delivery system like colon, gastro intestinal, buccal, dental etc....
The aim of this investigation was to develop novel multifunctional co-processed diluents for oral disintegrating tablets by melt granulation and wet granulation techniques. In case of wet granulation technique the co-processed diluents were formulated using micocrystalline cellulose and mannitol in the ratio 1:5.In case of melt granulation technique coprocessed diluents were formulated using PEG 4000 and PEG 6000, microcrystalline cellulose and mannitol were used as diluents, sodium starch glycolate as disintegrant . Magnesium stearate and talc were also incorporated as minor components in the diluent to improve tabletting properties. Donepezil HCl was used as poorly compressible model drug for preparation of tablets. The developed co-processed diluents were studied for their influence on flow, strength of the tablet and dissolution characteristics of Donepezil HCl from direct compressible tablets. Optimized co-processed formulation containing polyethylene glycol 6000 and mannitol was found to be more acceptable to formulate Donepezil HCl tablets. The preformulation parameters like flow property and the performance parameters were dependent on the method used for co-processing excipient. The co-processed excipient prepared with melt granulation technique imparted the desired qualities to the tablet....
The most commonly used of route of drug administration is oral route. But pediatric and geriatric patients have difficulty in swallowing or chewing solid dosage forms. Orodispersible dosage forms finds their application in pediatric and geriatric patients due to ease of administration which requires no water for administration and also offers rapid onset of action, improved bioavailability. Though several superdisintegrants are available for thr formulation of orodispersible tablets, there is continous need of investigationg new superdisintegrants which are cost effective and safe which can be used in the formulation of orodispersible tablets of poorly soluble drugs. The present work was aimed at preparing a novel superdisintegrant (starch tartrate) which can be used in the formulation of orodispersible tablets for more effective action of poorly soluble drugs....
Carbamazepine is used for anti convulsant and anti neuralgic effects. It is poorly soluble in water with erratic oral absorption and bioavailability less than 70%. More over carbamazepine has a narrow therapeutic range and shows bioavailability differences. In efforts to reduce the frequency of dosing required for chronic carbamazepine therapy and to decrease variability in plasma concentration, carbamazepine can be formulated in to controlled release systems In recent years, the natural hydrophilic polymer based matrix tablets as carrier for controlled release delivery has been widely and successfully used due to their ease of manufacturing, relatively low cost, favorable in vivo performance and versatility in controlling the release of drug with wide range of physicochemical properties. In the present study an effort was made to extract the Hibiscus rosa sinensis gum from the leaves of Hibiscus rosa sinensis and to evaluate it as controlled release polymer in the preparation controlled release matrix tablets of carbamazepine. The result of the present study demonstrated that the Hibiscus rosa sinensis gum obtained from the leaves of Hibiscus rosa sinensis is light green coloured powder which is amorphous in nature. Drug release from the prepared tablets was slowed over 24h and depended on the composition of Hibiscus rosa sinensis gum. Carbamazepine release was diffusion controlled and followed zero order kinetics. Non-fickian diffusion was the drug release mechanism from the prepared carbamazepine controlled release tablets. Therefore Hibiscus rosa sinensis gum is an efficient release retarding polymer for controlled release tablets....
Chitosan, a linear binary heteropolysaccharide, composed of β-1, 4-linked glucosamine (GlcN) with various degrees of N-acetylation of GlcN residues. It is a non-toxic, biocompatible and biodegradable natural polymer. Chitosan is prepared by alkaline N-deacetylation of chitin using concentrated sodium hydroxide (NaOH) solutions at high temperature for a long period of time. The degree of deacetylation (DD) and molecular weight (MW) are two fundamental parameters that can affect the properties and functionality of chitosan. Hydrophilic polymers are widely used in controlled release systems due to their favorable functionality. Enhancing the mobility of the polymer chains and diffusing of the drug out from such polymer matrices could be done by inclusion of different types of excipients at different concentrations. The present research paper highlights the attempt made to reveal the influence of the solubility of excipient on drug release from matrix systems with varying concentration of different grades of chitosan....
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