Current Issue : July - September Volume : 2013 Issue Number : 3 Articles : 5 Articles
Liquisolid system has attracted considerable interest as an efficient means of improving the dissolution rate and hence increases the bioavailability of a range of hydrophobic drugs. By this new formulation technique, a liquid drug may be converted into a dry-looking, non-adherent, free flowing and easily compressible powder by simply blending with selected powder excipients referred to as carrier and coating materials...
A pharmaceutical formulation is composed of system based on a computational techniques, several formulation factors and process variables. Optimization techniques are used in industrial planning, allocation, scheduling, decision-making, etc. An artificial neural network is a computational simulation of a biological neural network. These models mimic the real life behaviour of neurons and the electrical messages they produce between input, processing by the brain and the final output from the brain. There are many types of neural networks designed and new ones are invented but all can be described by the transfer functions of their neurons, by the learning rule, and by the connection formula. ANN structure consists of one input layer, one or more hidden layers and one output layer. This feature of ANN, to extract information from the data presented to them, proves them to be powerful and flexible tools for modelling and predictive purposes and offers great potential for applications in a various field. ANNs are being used in pharmaceutical research to predict the nonlinear relationship between causal factors and response variables. Over past decades ANN have gained more acceptance in pharmaceutical formulation modelling because of some advantages like enhance product quality and performance at low cost and need short time to market and new product development, improve response of product as well as customer and improve confidence. The review enlists various dosage form developed, utilizing ANN and various ANN softwares used for this purpose....
The objective of the present study was to investigate whether the technique of Solid Dispersion would be helpful for enhancing the dissolution of Meloxicam. Solid dispersions of Meloxicam were prepared by solvent evaporation method using carriers such as Sodium Starch Glycolate, Croscarmellose sodium. Solid dispersions were characterized by differential scanning calorimetry and evaluated for dissolution profiles of meloxicam. A marked increase in dissolution rate was observed with all solid dispersion. Among the carriers studied sodium starch glycolate gave the highest improvement in dissolution rate. Selected dispersions were used to prepare tablets, which were evaluated for the dissolution profiles of meloxicam and also subjected to stability studies. In vivo studies were carried out by treating rats orally with pure meloxicam and dispersion of meloxicam to investigate reduction in ulcerogenecity and the solvent evaporated dispersion was found to reduce the ulcerogenecity of the drug....
Microwave-assisted extraction (MAE) technique was developed for the extraction of sennosides from Cassia angustifolia. Several influential parameter of the MAE procedure (Ethanol concentration, Solvent volume, Microwave power and Extraction time) were studied through single factor experiments and orthogonal experiments for the optimization of the extraction protocol. The optimal condition of the MAE were : Ethanol concentration 60%, Solvent volume 40ml, Microwave power 140W and Extraction time 7 min, while extraction yield of sennoside was 18.66% mg/g. The developed MAE method provide a good alternative for the extraction of sennoside from Cassia angustifolia....
To launch a drug in market is known as new drug approval (NDA) process. A drug approval process comprises of various stage, application to conduct pre-clinical trials, clinical trial, and application to marketing authorization of drug and post-marketing studies. Different country has its own regulation and guidelines to regulate the marketing of drugs. The reason for this article is to present overview of drug approval process. It will briefly review journey of new product from early stage of development until it approved by FDA for prescription use....
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