Current Issue : October - December Volume : 2014 Issue Number : 4 Articles : 5 Articles
The efficacy and rapidity of action of topical corticosteroids used for their anti-inflammatory and anti-proliferative effects has made topical corticosteroids as drugs for the treatment most often used to manage mild or moderate psoriasis. Budesonide is a potent corticosteroid which presents an improved risk/benefit ratio. The aim of this work was to prepare a hydrogel formulation using various polymers like carbopol-940 and carbopol 934 in different concentrations of 0.5%, 0.75% and 0.1% (w/w). The formulated gel was evaluated for drug content, pH, viscosity, spreadability, ex-vivo diffusion study, in-vivo skin irritation study and anti-psoriatic activity. Spreadability of carbopol gel with concentration of 0.1% (w/w) containing budesonide (G6) was 5.6 cm which indicates good spreadability of the prepared gel. The drug content of batch G6 of budesonide hydrogel was found to be 99.99±1.214%. The percent drug release in 12 h from batch G6 was 35.27% which indicates that G6 batch of hydrogel releases drug in sustained manner compared to all other batches of hydrogels. G6 batch containing 1% carbopol 940 showed lowest diffusion of 35.27% release of budesonide in time period of 12 h which reveals the sustained release of drug from gel. Anti-psoriatic activity was screened by applying topical application of Budesonide gel by using mouse tail model. Histopathologically number of features such as epidermal thickness, elongation of rete ridges and granular cell layer of control group and budesonide gel group were observed. All these observations conclude that budesonide gel is good drug delivery system for topical treatment of psoriasis....
The aim of the present work was to investigate the possibility of enhancing the dissolution rate of ketoprofen (KP) through inclusion into SBA-15 mesoporous silica nanoparticles. Two different KP concentrations were loaded into SBA-15. The loading capacity was examined via solvent extraction method, differential scanning calorimetry (DSC) and wide angle X-ray diffraction (WAXRD). Characterization of the loaded mesoporous silica nanoparticles was done by high resolution transmission electron microscopy (HRTEM), small angle X-ray diffraction (SAXRD) and nitrogen adsorption/desorption isotherms. The characterization results revealed successful inclusion of KP into SBA-15 without affecting the mesoporous structure; also it showed that all KP loaded was confined into the mesopores without any trace for surface adsorbed molecules. Dissolution studies were carried out at pH 1.2 and 6.8. The results showed that KP release from SBA-15 was highly improved independent on the pH of the release medium. This study is a promising issue for providing a more facile way to improve the dissolution rate of poorly water-soluble drugs through incorporation into mesoporous silica nanoparticles....
Recently, we have heard about several drug product recalls due to several reasons, in which drug mix-ups is the major one. Good Manufacturing Practice (GMP) is the key regulation for any pharmaceutical industry to being approved for sale its good all over the world. Also, World Health organization (WHO) has set the standards for all the countries, but due to several reasons like misconduct of GMP will lead to only one result and that is recall of the product with recalling reputation of the company, also. This review focuses on such recent drug mix-ups taken place recently and it also throw somewhat light to GMP, also. Aim behind publishing this review is not to criticize anybody involved in the process, but it is published to develop awareness to the society. After reading this review, patient should first ask about the drug product he/she is taking, whether same lot is recalled off or not. Such a small precaution will save several lives because these mix-ups can lead to death of the patient, also....
The objective of present study was to investigate the effect of sintering on sustained release matrix tablets containing ambroxol hydrochloride, dicalcium phosphate, magnesium stearate, talc and using different concentration of various retarding materials such as compritol and HPMC K15M. The tablets were compressed by direct compression method and formulation was sintered at various temperatures and time points. Sintering i.e. application of heat, causes the bonding of adjacent particle surfaces in a mass of powder or in a compact leading to the retardation of drug release. The formulations were sintered by two methods i.e. by employing hot air oven and microwave oven. The sintered tablets were characterized by their physical parameters and in-vitro dissolution tests. FT-IR and differential scanning calorimetry studies ruled out the occurrence of drug interaction after sintering condition. Formulation containing compritol (10.2%) provided the release profile of 12 h when subjected to sintering at 80C for 3 h....
Formulating fast dissolving tablet (FDT) using solid dispersion of drug shall not only improve solubility and consequent bioavailability but also improved patient compliance and convenience. The aim of the present study was to improve the solubility of candesartan cilexetil (CAN) by solid dispersion (SD) technique and formulate it as fast dissolving tablets using superdisintegrants. Solid dispersion of CAN was prepared by physical mixture, kneading, solvent evaporation, microwave irradiation method using polyethylene glycol (PEG) 4000 and PEG 6000 as a carrier. Different weight ratios of drug and carrier i.e. 1:1, 1:2, 1:3, 1:4 and 1:5 were taken. Solubility of drug was determined in physical mixture and SD formulations. The prepared SD formulations were characterized by fourier transform infra-red (FTIR), differential scanning calorimetry (DSC), x-ray diffraction (XRD) and in-vitro drug release. FDT of CAN was formulated using optimized SD formulation of drug and carrier along with the superdisintegrant such as crosscarmellose sodium. From FTIR, DSC and XRD studies, it was concluded that there is change in crystalline form of drug into amorphous formulation of SD. Fast dissolving tablet containing crosscarmellose sodium (5%) as superdisintegrant showed the fastest disintegration (30 sec) and in-vitro drug release (98.2%). It can conclude that combination of SD and superdisintegrants is promising approach to prepare efficient FDT of candesartan cilexetil....
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