Current Issue : January - March Volume : 2014 Issue Number : 1 Articles : 7 Articles
The objective of the present work was to study the antidiabetic effect of aqueous extract of Murraya koenigii stem bark against alloxan induced diabetes in rats. The diabetes was induced by single dose of alloxan (150 mg/kg, i.p.). 03 days after induction of diabetes, the diabetic animals were treated further for 11 days with aqueous extract of Murraya koenigii stem bark (125 mg/kg and 250 mg/kg) and metformin (50 mg/kg). Blood glucose estimation was performed on 0, 4, 7 and 10th day. At the end of study period, animals were sacrificed for biochemical investigations. Alloxan induced diabetic rats showed marked hyperglycemia at the end of study period. Body weight and liver glycogen levels were significantly reduced in diabetic rats. Posttreatment with aqueous extract of Murraya koenigii stem bark for 11 days (125 mg/kg and 250 mg/kg) significantly ameliorated the alterations in fasting blood glucose, serum triglyceride, serum cholesterol, liver glycogen levels as well as body weight in diabetic rats. Thus, present study suggested the potential antidiabetic activity of aqueous extract of Murraya koenigii stem bark against diabetes mellitus....
Based on literature Glycine max shows action on central nervous system and specially acts on glycine receptors, where glycine acts as an inhibitory neurotransmitter. The anticonvulsant effects of alcoholic and petroleum ether extracts of Glycine max in maximum electric shock in mice was tested. Glycine max (Soybean), dry seeds were collected, dried and coarsely powdered and latter was soxhelated using petroleum ether and absolute ethanol and air dried to obtain sticky dried extract. Four groups of male Swiss Albino mice (20-30 g) were used in this study. Group I animals received the normal saline for 10 days, Group II received standard drug phenytoin (25 mg/kg, p.o.) for 10 days, Group III animals received Glycine max alcoholic extract (50 mg/kg, p.o.) for 10 days, Group IV animals received Glycine max petroleum ether extract (50 mg/kg, p.o.) for 10 days. On 11th day the electroshock was delivered by using corneal electrodes. The intensity of stimulus was 50-100 mA, 50 Hz, for 0.2 sec. The animals were observed closely for 2 min and the parameters such as disappearance of the hind leg extensor, tonic convulsion was used as positive criterion. Percent of seizure inhibition relative to control was calculated. The Glycine max alcoholic and petroleum ether extracts significantly (P<0.01) decreased the extension phase and also the clonic convulsive phase, and showed protection in MES induced seizures when compared with phenytoin (p<0.01). The chronic administration of alcoholic as well as petroleum ether extracts significantly (P<0.01) increased the tissue glutathione and decreased the malondialdehyde and protein level in brain. In conclusion, both the extracts of Glycine max have shown potent anticonvulsant action in MES induced seizures....
The current aim of this research work includes: to evaluate acute toxicity of crude methanol extract of dried ripe fruits of Neoalsomitra clavigera in female albino rats, fractionation of crude methanol extract by normal phase column chromatography, quantification of lupeol by HPTLC in chloroform green band fraction, calculation of LD50 for lupeol rich green column band fraction and their comparative Streptozotocin (STZ) induced in-vivo anti-diabetic activity. The main aim of selection of this research work is to explore leading novel bioactive compound present in ripe fruits of Neoalsomitra clavigera, which has possible role in curing STZ induced diabetes in albino rats. In HPTLC studies, lupeol was quantified (279.43 �µg) in chloroform green band fraction. The lupeol rich chloroform fraction was significantly reduced blood glucose label (p<0.05) on 7th day and significant change found in biochemical parameters like albumin (p<0.05) and cholesterol (p<0.01) on 14th day of drug treatment. a proposed mechanism of antidiabetic action of Neoalsomitra clavigera extract is also given in this research manuscript.\r\nKey words: Neoalsomitra, HPTLC quantification, Lupeol, Anti-diabetic studies....
Indian bay leaf has been reported as folklore medicine for treatment of various disorders in alone as well as in\r\ncombination with other herbs. Many investigators have reported activity of bay leaf in hyperglycemia, wound healing, ulcers,\r\ndiarrhea, immunity and digestive disorders. In present study we investigated effect of ethanolic extract of Cinnamomum tamala\r\nleaves on advance glycation in streptozotocin induced diabetic rats. The diabetic rats were treated with ethanolic extract of bay\r\nleaves at a dose of 100 mg/kg orally for 14 days and found significant decrease in blood glucose, glycated hemoglobin, glycated\r\nalbumin and serum fructosamine level in treated diabetic rats as compared to non treated diabetic rats....
Interest in plant-derived alternative medicine that affects the “Brain” is attenuating due to the deleterious effects of modern era synthetic drugs. The aim of present study was to explore the anti-anxiety activity of ethanolic and aqueous extracts of fruits of Ziziphus jujuba herb using elevated plus maze anti-anxiety model in mice. Diazepam (2mg/kg) was used as the standard and two each doses of ethanol and aqueous extracts i.e., 200 and 400 mg/kg were selected for study as per OECD guidelines. Results suggested that extract of Z. jujuba at 200 mg/kg dose produced anti-anxiety effects almost similar to diazepam. Further studies are needed to identify the anxiolytic mechanism(s) and the phytoconstituents responsible for the observed central effects of the ethanolic and aqueous extracts of fruits of Z. jujuba....
Classical texts of Ayurveda advocate the use of seeds of Kulattha (Dolichos biflorus Linn. synonym Vigna unguiculata Linn. Fabaceae) both as drug and diet. It is recommended as a drug of choice for the management of urinary calculi (Ashmari). Kulattha (Horse gram) is considered to have the proclivity for producing acid peptic disorders (Amlapittajanana) and as unwholesome diet item in disease conditions like Visarpa (Erysipelas), Kushtha (Skin disease), Raktapitta (Haemmorhagic disease), Vatarakta (Gout) etc. The aim is to evaluate safety profile of Kulattha seeds. Powder suspension was administered in therapeutic dose (TED) (350 mg/kg/day), and fivefold of therapeutic dose (TED× 5) (1800 mg/kg/day), for sixty days, in albino rats and effect on different parameters was studied. Control group received distilled water. Paired and unpaired Student's t test for respective data with the level of significance set at P<0.05. Significant decrease (P<0.01) was observed in blood urea in TED group, SGPT activity was found to be decreased (P<0.05) in TED×5 group while direct bilirubin was decreased (P<0.05) at both doses of Kulattha. Significant increase (P<0.05) was observed in total WBC count with both the doses of Kulattha. No significant changes were observed in rest of the studied parameters. Thus increase in WBC is the only change which can be considered to be of some pathological significance. It can be inferred that at the doses studied Kulattha is not likely to affect functioning of the vital organs....
Dementia or cognitive dysfunction is the common problem in today’s fast life. Age, stress and emotions are the condition that may lead to memory loss. In traditional system of Ayurvedic medicine, numerous herbs possessing saponins have been used to treat cognitive disorder. Taverniera cuneifolia (Fabaceae) is the rich source of saponins. Two doses (100 and 200 mg/kg, p.o.) of n-butanolic fraction Taverniera cuneifolia extract (TCE) were administered for 7 successive days in separate group of animals. Furthermore, on the 7th day scopolamine (0.4 mg/kg, p.o.) administered to as cognitive deficit. The series of established neuropharmacological tests including elevated plus maze and passive avoidance paradigm were studied on 7th and 8th day. Baclofen induced hypothermia and measurement of acetylcholinestrase (AChE) activity were also carried out. TCE significantly improved learning and memory both in absence and presence of cognitive deficit. Also reversed the baclofen induced hypothermia. The mechanism by which TCE exerts nootropic activity was decreased AChE activity and inhibition of GABAB receptor. With the above data, we can conclude that Taverniera cuneifolia extract shows potent nootropic activity both in absence and presence of cognitive deficit....
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