Current Issue : July - September Volume : 2014 Issue Number : 3 Articles : 3 Articles
The aim of this investigation was to develop natural superdisintegrant by modify physically properties of patent guar gum using hot air drying technique. Batches of modified guar gum were prepared by subjecting patent guar gum to sequential processes of aqueous wetting and drying using hot air oven. The effect of ratio of guar gum to water and different temperature during formulation of orodispersible tablet of a model drug olanzapine by 32 factorial design was used on disintegration time, wetting time and water absorption ratio of the formulations. The guar gum and modified guar gum were characterized by infra red spectroscopy and scanning electron microscopy and evaluated for physical properties. The least disintegration time of 27sec was obtained using by the ratio of guar gum to water X1 (1:1.25) and temperature X2 (60°). Short term stability studies indicated no significant changes in hardness, friability, in-vitro disintegration time, wetting time, water absorption ratio, drug content and in-vitro drug release....
Lubrication plays a key role in successful manufacturing of pharmaceutical solid\ndosage forms; lubricants are essential ingredients in robust formulations to achieve this.\nAlthough many failures in pharmaceutical manufacturing operations are caused by issues\nrelated to lubrication, in general, lubricants do not gain adequate attention in the\ndevelopment of pharmaceutical formulations. In this paper, the fundamental background on\nlubrication is introduced, in which the relationships between lubrication and friction/adhesion\nforces are discussed. Then, the application of lubrication in the development of pharmaceutical\nproducts and manufacturing processes is discussed with an emphasis on magnesium stearate.\nIn particular, the effect of its hydration state (anhydrate, monohydrate, dihydrate, and\ntrihydrate) and its powder characteristics on lubrication efficiency, as well as product and\nprocess performance is summarized. In addition, the impact of lubrication on the dynamics\nof compaction/compression processes and on the mechanical properties of compacts/tablets\nis presented. Furthermore, the online monitoring of magnesium stearate in a blending\nprocess is briefly mentioned. Finally, the chemical compatibility of active pharmaceutical\ningredient (API) with magnesium stearate and its reactive impurities is reviewed with\nexamples from the literature illustrating the various reaction mechanisms involved....
In the recent time, many of the research groups have turned their focus to research on oral thin film technology for oral route. Oral thin films are the solid dosage form which leads to easy fragmentation or dissolution within 1 min when placed on the patient tongue. Formulation of oral thin films includes API, film forming polymer, plasticizer, saliva stimulating agent, flavour, sweetener etc. Film forming polymers play a standout role in tenacity and the resilience of oral thin films. Recently it has been natural polymers that are widely used because of their enormous advantages over synthetic polymers like biocompatibility, biodegradability, intactness, easy availability and economically more sound. This review spotlights the information about various natural polymers used in oral thin film. It also focuses on their advantages, properties and applicability in oral thin film technology as a film forming polymer....
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