Current Issue : January - March Volume : 2015 Issue Number : 1 Articles : 9 Articles
Many medicinal plants claimed traditionally for its properties to cure the diseases. Some of them also claim the property to control the diabetic condition in humans but systematic evaluation of many plants are not done yet. Echinops echinatus Roxb, (Compositae) (EE), commonly known as brahmadandi, possesses several medicinal properties; little is known about its traditional use as antidiabetic. The purpose of the study was to evaluate the antidiabetic activity of methanol extract of roots bark (RBEE) (250 and 350 mg/kg) and aerial parts (APEE) (250 and 350 mg/kg) of Echinops echinatus using alloxan induced hyperglycemia. In the same study the action of the extract on diabetes induces hyperlipidemia was analysed where the extracts significantly lowered the elevated cholesterol as well as LDL level. The antihyperglycemic action of the extracts may be due to the blocking of glucose absorption. All extract of Echinops ehinatus produced a significant antidiabetic activity....
The objective of the present study was to evaluate the antioxidant activity, antitumor effect, and antiaging property of\nproanthocyanidins from Kunlun Chrysanthemum flowers (PKCF) grown in Xinjiang. In vitro antioxidant experiments results\nshowed that the total antioxidant activity and the scavenging capacity of hydroxyl radicals (?OH) and 1,1-diphenyl-2-picrylhydrazyl\n(DPPH?) radicals increased in a concentration-dependent manner and were stronger than those of vitamin C. To investigate the\nantioxidant activity of PKCF in vivo, we used serum, liver, and kidney from mouse for the measurement of superoxide dismutase\n(SOD), malondialdehyde (MDA), and total antioxidant capacity (T-AOC). Results indicated that PKCF had antioxidative effect\nin vivo which significantly improved the activity of SOD and T-AOC and decreased MDA content. To investigate the antitumor\nactivity of PKCF, we used H22 cells, HeLa cells, and Eca-109 cells with Vero cells as control. Inhibition ratio and IC50 values were\nmeasured by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay; PKCF showed great inhibitory activity\non H22 cells and HeLa cells.We also used fruit flies as a model for analyzing the anti-aging property of PKCF. Results showed that\nPKCF has antiaging effect on Drosophila. Results of the present study demonstrated that PKCF could be a promising agent that may\nfind applications in health care, medicine, and cosmetics....
In an attempt to determine the antioxidant/prooxidant, antibacterial/probacterial action of flavan-3-ols and procyanidins from\ngrape seeds, pure catechin (CS), and an aqueous grape seed extract (PE), were applied in the absence and presence of pure\nlipoxygenase (LS) or in extract (LE) to leucocyte culture, Escherichia coli B41 and Brevibacterium linens, and observed whether there\nwas any effect on lipid peroxidation, cytotoxicity, or growth rate. Short time periods of coincubation of cells with the polyphenols,\nfollowed by the exposure to LS and LE, revealed a high level of lipid peroxidation and a prooxidative effect. Longer coincubation\nand addition of LS and LE resulted in the reversal of the prooxidant action either to antioxidant activity for CS + LS and PE + LS or\nto the control level for CS + LE and PE + LE. Lipid peroxidation was significantly reduced when cells were exposed to polyphenols\nover a longer period. Longer exposure of E. coli to CS or PE followed by addition of LS for 3 h resulted in bactericidal activity.\nSignificant stimulatory effect on microbial growth was observed for PE + LS and PE + LE treatments in B. linens, illustrating the\npotential probacterial activity in B. linens cultures. Lipoxygenase-polyphenols complex formation was found to be responsible for\nthe observed effects....
The Erythrina variegata Linn (Leguminosae) is a medium sized deciduous small tree. Various parts of this plant is used for treatment of fever, inflammation and joint pain, earache, toothache, constipation, cough and also known to stimulate lactation and menstruation. Different parts of E. variegata are used in traditional medicine as nervine sedative, febrifuge, antiasthmatic and antiepileptic. The present study was aimed at the evaluation of aqueous extract of leaf by using egg albumin precipitate method. The clotting time on adding aqueous leaf extract was 3 minutes 24 seconds and the bleeding time on adding aqueous leaf extract was 40 seconds. The aqueous extract of Erythrina variegata L. showed significant coagulant activity....
The present study was performed by the in-vitro method to screen the anti cancer activity on the different concentrations (10 mcg/ml – 400 mcg/ml) of the ethanolic extract of Cressia cretica L. and Garcinia indica on DAL cells using tryphan blue method. The ethanolic extract of the plants showed significant result on 200 mcg/ml....
Plants have been used for medical purposes since the beginning of human history and are the basis of modern medicine. Most\nchemotherapeutic drugs for cancer treatment are molecules identified and isolated from plants or their synthetic derivatives. Our\nhypothesis was that whole plant extracts selected according to ethnobotanical sources of historical use might contain multiple\nmolecules with antitumor activities that could be very effective in killing human cancer cells. This study examined the effects of\nthree whole plant extracts (ethanol extraction) on human tumor cells. The extracts were from Urtica membranacea (Urticaceae),\nArtemesia monosperma (Asteraceae), and Origanum dayi post (Labiatae). All three plant extracts exhibited dose- and timedependent\nkilling capabilities in various human derived tumor cell lines and primary cultures established from patients� biopsies.\nThe killing activity was specific toward tumor cells, as the plant extracts had no effect on primary cultures of healthy human cells.\nCell death caused by the whole plant extracts is via apoptosis. Plant extract 5 (Urtica membranacea) showed particularly strong\nanticancer capabilities since it inhibited actual tumor progression in a breast adenocarcinoma mouse model. Our results suggest\nthat whole plant extracts are promising anticancer reagents....
The aim of this study was to determine the composition and content of phenolic compounds in the ethanol extracts of apple leaves\nand to evaluate the antioxidant activity of these extracts. The total phenolic content was determined spectrophotometrically, as well\nas the total flavonoid content in the ethanol extracts of apple leaves and the antioxidant activity of these extracts, by the ABTS,\nDPPH, and FRAP assays. The highest amount of phenolic compounds and flavonoids as well as the highest antioxidant activity\nwas determined in the ethanol extracts obtained from the apple leaves of the cv. Aldas. The analysis by the HPLC method revealed\nthat phloridzin was a predominant component in the ethanol extracts of the apple leaves of all cultivars investigated. The following\nquercetin glycosides were identified and quantified in the ethanol extracts of apple leaves: hyperoside, isoquercitrin, avicularin,\nrutin, and quercitrin. Quercitrin was the major compound among quercetin glycosides....
Medicinal plants and the medicines derived from them have been used all over the world. They are becoming an alternative source to synthetic drugs. Herbal and ayurvedic drug treatment is not only used in India but has global commercial market. Tagetes erecta has wide ethno medicinal and traditional uses. It demonstrates different pharmacological activities like antioxidant, antimicrobial and anti depressant. A variety of phytoconstituents are present in plant which are responsible for showing various bioactivities. Present review was done to summarise various reporting on traditional uses, scientific justification for bioactivity and chemical constituents of Tagetes erecta....
Two experiments were simultaneously conducted with Morus alba (white mulberry) foliage extract (MFE) as a growth promoter\nand treatment of Aeromonas hydrophila infection in separate 60 and 30 days trail (Experiments 1 and 2, resp.) in African catfish\n(Clarias gariepinus). In Experiment 1, four diets, control and control supplemented with 2, 5, or 7 g MFE/kg drymatter (DM) of diet,\nwere used. In Experiment 2, fish were intraperitoneally infected with Aeromonas hydrophila and fed the same diets as experiment\n1 plus additional two diets with or without antibiotic. Results of experiment 1 showed that growth was unaffected by dietary levels\nof MFE. Treatments with the inclusion of MFE at the levels of 5 and 7 g/KgDMhad no mortality. Red blood cells (RBC), albumin,\nand total protein were all higher for the treatments fed MFE (5 and 7 g/KgDM). Results of experiment 2 showed RBC, hemoglobin,\nhematocrit, globulin, albumin, and total protein improved with the increase in MFE in the infected fish. The dietary MFE at the\nlevel of 7 g/kgDM reduced mortality rate. In conclusion, MFE at the level of 7 g/kgDM could be a valuable dietary supplement to\ncure the infected fish....
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