Current Issue : April - June Volume : 2015 Issue Number : 2 Articles : 5 Articles
Advancement in herbal drug delivery can breakthrough barriers of poor bioavailability in traditional herbal drug delivery. Curcumin, besides its major drawback of poor bioavailability, is proven as potential anti-inflammatory and anti-neoplastic drug. This research work explains methods for development and optimization of curcumin self-micro emulsifying formulation. Box-Behnken Response Surface methodology was employed in optimization process to keep numbers of run minimum. Based on solubility study of curcumin in various excipients, Capmul-MCM®, Acconon-MC8®, Acrysol-EL135® and Polysorbate-80 were selected as components for development of lipid based formulation. Ternary phase diagrams were employed to determine lower and higher levels for experimental design. Amount of components of formulation were selected as independent factor, while droplet size, polydispersibility index and rate of emulsification were selected as dependent factors. Various characterizations of optimized self-emulsifying formulation were also evaluated. Optimized formulation revealed was: 200 mg curcumin, 2.2 ml capmul MCM, 1.6 ml acrysol EL135, 4.4 ml acconon MC8 and 1.6 ml propylene glycol....
Over recent years, drug release/dissolution from solid pharmaceutical dosage forms has been the subject of intense and profitable scientific developments. Whenever a new solid dosage form is developed or produced, it is necessary to ensure that drug dissolution occurs in an appropriate manner. In the present study sustained release floating microsphere of diltiazem hydrochloride were prepared by using non aqueous solvent evaporation method using polycarbonate, chitosan, ethyl cellulose, HPMC and acrycoat as materials in various quantities, in varying ratio to formulate 20 formulations of the floating microsphere. The drug release was studied using a USP 24 dissolution apparatus type I (Veego Scientific, Mumbai) at 100 rpm in 0.1N hydrochloric acid as dissolution medium (900 ml) maintained at 37±1°C. It has been noticed that on increasing the concentration of polymer it decreased the drug release from microspheres. The high concentration of polymer makes the microsphere stiff. This hardness of microsphere decreases the rate of drug release from microspheres. The F3 released 98.72% drug at 16 hrs. The F3 exhibited the sustained release of drug from microspheres. The release mechanism was explored and explained with zero order, first order, higuchi and korsmeyer and peppas equations....
In present study, immediate release tablets were prepared using nanocrystals to optimize dissolution properties of lipophilic, poorly soluble drug nateglinide (NTG). Different batches of nanocrystals were prepared by 32 full factorial design using DOE software. The factorial design used for optimization of preparation to independent factor concentration ratio of poloxamer 188 and stirring speed also with dependant factor particle size and dissolution rate. The nanocrystal preparation was prepared by high pressure homogenization techniques and poloxamer 188 as stabilizer. Characterization of NTG nanocrystals was carried out by infrared spectroscopy (FTIR), x-ray powder diffractometry (XRPD), differential scanning calorimetry and photon correlation spectroscopy. Dissolution study of NTG nanocrystals immediate release tablet was performed in 0.1 N HCl and was compared to that of NTG coarse suspension, NTG/poloxamer 188 physical mixture and bulk NTG samples. The solubility of the NTG nanocrystals immediate release tablet formulation conclude that the improvement in NTG dissolution rate was mainly caused by increased surface to volume ratio due to the submicron dimension of the drug particles....
Floating tablet of levofloxacin hemihydrate was prepared by direct compression technique. Levofloxacin hemihydrate was chosen as model drug because it is effective for the eradication of H. pylori and it has site-specific absorption in stomach and plasma half life of 5-6 hrs as well. All these criteria make levofloxacin hemihydrate suitable candidate for floating Tablet. Kollidon® SR was used as directly compressible vehicle and floating carrier. A 32 randomized full factorial design was applied to optimize variables. Amount of hydroxyl propyl methyl cellulose HPMC K4M (X1) and sodium starch glycolate SSG (X2) were selected as independent variables. The Cumulative percentage drug release was selected as dependent variable. HPMC K4M was used as a hydrophilic polymer, to control the release of highly water soluble levofloxacin hemihydrates and SSG was added not for disintegrating the tablets, but lower concentration of superdisintegrant in the matrix tablet increases the surface erosion of the tablet thereby increases the drug release rate. The tablets were evaluated for in-vitro buoyancy and dissolution studies. The tablets were evaluated for physical characteristic viz. hardness, floating capacity, thickness, friability and weight variation. Further, tablets were evaluated for in-vitro release characteristic for 10 hrs. To confirm the exact mechanism of drug release from different formulation, the data was fitted to korsmeyer peppas equation and value of correlation coefficient in korsmeyer – peppas model was nearer to 1 than any other model which indicates best fitting model for all the batches of factorial design....
The aim of the present work was to prepare caffeine niosomes by thin film hydration method using various types of surfactants and applying different surfactant: cholesterol ratios for the treatment of cellulite. Surfactant used were (span 20, 60, 65, 80 and 85), cholesterol was added with (0, 10, 20, 30, 40 and 50%). The prepared niosomes were evaluated by determination of particle size using transmission electron microscope (TEM), determination of entrapment efficiency (E.E. %) and in-vitro drug permeation study through rat skin. The particle size of the prepared niosomes ranged between 174 and 380 nm, the highest entrapment efficiency of caffeine (94.18%) occurred with span 60 (F12S60) which contains Span 60: Cholesterol with ratio (50:50) respectively. While (F22S80) which contains Span 80: Cholesterol with ratio (70:30) respectively gave the highest steady state flux of (62.51 µg cm-2 hr-1).The results revealed that Span 60 gave the highest entrapment efficiency and Span 80 gave the highest in-vitro permeation....
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