Current Issue : April - June Volume : 2015 Issue Number : 2 Articles : 3 Articles
A new series of some new 2-(substituted phenyl)-4h-chromen-4-one derivatives were synthesized. The structures of these synthesized compounds were confirmed by IR, NMR and CHN analysis. All the values and results of these spectral and elemental analyses were found to be in the normal range. These compounds were subjected to anti-inflammatory activities by carrangen induced paw edema method using diclofenac sodium as a standard drug. Most of these compounds have shown excellent anti-inflammatory activities....
Tyrosine kinases (TK) are enzymes that bind ATP and catalyse the transfer of γ-phosphate to tyrosine residues on proteins, thereby regulating their activity and function which can be targets for cancer chemotherapy. Pyrrolo[2,3-d]pyrimidines have aroused recent attention from chemical and biological view points since they have useful properties as being the receptor tyrosine kinases inhibitor. 5,6-Diphenyl-7-substituted-7H-pyrrolo[2,3-d]pyrimidin-4-yl-amineswere synthesized and perform in-vitro EGFR tyrosine kinase activity and from above study, (08a, 08b, 08c) gives excellent in-vitro EGFR activity in compare to standard gifitinib....
Several five membered aromatic systems having three heteroatoms at symmetrical positions such as thiadiazoles\nhave been studied for their interesting pharmacological activities. This review article covers the most active thiadiazole\nderivatives that have shown considerable biological actions such as anti-inflammatory, antimicrobial, anticonvulsant,\nanticancer. This review also discusses the structure-activity relationship of the most potent compounds. It can act as an\nimportant tool for medicinal chemists to develop newer compounds possessing thiadiazole moiety that could be better agents in\nterms of efficacy and safety....
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