Current Issue : July - September Volume : 2015 Issue Number : 3 Articles : 10 Articles
The bark of Anogeissus latifolia (Roxb. ex DC.) Wall. ex Guill. and Perr. (Combretaceae) has been reported to be used in the treatment of various diseases like wound healing, antioxidant activity and skin disease. The anti-inflammatory activity of Hydroalcoholic extract of bark of Anogeissus latifolia was evaluated in rodents using acute and chronic inflammatory models in order to validate ethnobotanical claims regarding the plant use in the above mentioned diseases. Anti-inflammatory potential of Anogeissus latifolia extract (ALE) (200 and 400 mg/kg body weight) was studied in acetic acid induced vascular permeability, croton oil induced ear edema and increase capillary permeability in ear. Cotton pellet granuloma, antioxidant enzyme estimation (LPO, SOD, GSH, and Catalase) and determination of serum level IL-6 and TNF- α using enzyme linked immunosorbent assay. Antioxidant enzymes and IL-6 and TNF- α estimation were done in cotton pellet induced granuloma inflammatory model. The results of present study showed for the first time that ALE possesses anti-inflammatory activity by significant inhibition of increase vascular permeability, inhibition of ear edema and reduced weight of cotton pellet. ALE decreased LPO while concurrently increase SOD, GSH and Catalase level. ALE also decreases the level of IL-6 and TNF-α in serum of treated groups compare to control one. Hence present study demonstrated that A. Latifolia bark extract has a potent anti-inflammatory activity against different phases of inflammation....
The study was aimed to evaluate the antiparkinsonism activity of the leaves of Caesalpinia mimosoides Lamk. The ethanolic extract of Caesalpinia mimosoides Lamk leaves were evaluated for the antiparkinsonism activity against rotenone induced parkinsonism rats. Behavioral assessments such as catalepsy, muscle rigidity and locomotor activity were noted. Phytochemical tests indicated the presence of alkaloids, steroids, carbohydrates, saponins, tannins, flavonoids and phenolic compounds. Oral administration of the test extract (200 mg/kg) were significantly reversed the rotenone induced changes in oxidative stress markers, histopathological changes and behavioral alterations, which indicates the antiparkinsonism activity of the test extract. In conclusion, the present study suggests that ethanolic extract of Caesalpinia mimosoides Lamk show beneficial effects in relieving symptoms of parkinsonism....
Flavonoids are well known to possess anxiolytic activity. Quercetin produces anxiolysis by acting on α1β1γ2s GABAA receptors. The presence of flavonoids in Cydonia oblonga leaves has been reported. The major flavonoid in Cydonia oblonga leaves is quercetin.To the best of our knowledge, there has been no scientific study to evaluate the anxiolytic activity of Cydonia oblonga. Based on the notion that quercetin present in Cydonia oblonga could be helpful in anxiety, we investigated anxiolytic-like activity of a flavonoid rich methanol extract of Cydonia oblonga (MECO) using elevated plus maze, light/dark box and open field apparatus in mice. The extract was given orally by gavage at the dose of 500 and 800 mg/kg body weight. Diazepam (1 mg/kg i.p.) was used as the standard drug. It was observed that the extract significantly increased the time spent in the open arm and the number of entries in the open arm compared to control group in elevated plus maze. The time spent in the light cubicle of light/dark box apparatus was also increased significantly. The extract also demonstrated a significant and dose dependent increase in ambulation and rearing in open field test. These findings suggest that MECO possesses anxiolytic-like potential, which is most likely produced through quercetin and other flavonoids mediated potentiation of GABAA receptors....
Caesalpinia sappan L. is a plant used in traditional systems of medicine for different therapeutic purposes. The plant was said to possess anthelmintic, antiarthritic, antithrombotic, hepatoprotective, antiallergic and antimicrobial activities. This study was aimed at evaluating the antihyperglycemic potential of the parts of the plant namely, heartwood, bark and aerial parts. Peripheral uptake of glucose by GLUT-4 and utilization of glucose are trivial for normal glucose homeostasis. The bark of the tree was found to stimulate glucose uptake in L6 cell lines....
Present study investigated the role of ZML extracts in alloxan induced hyperalgesia in mice. Alloxan (150 mg/kg; i.p) induces diabetes in mice and long standing hyperglycemia (for 21 days) causes diabetic neuropathy. 30 mice were divided in 6 groups, each group containing 5 mice: Non diabetic group, diabetic group and ZML treated groups (Ethanol and Acetone extract, 100 and 250 mg/kg respectively). Mice were orally administered with ZML extract daily for 21 days starting from 15th day after alloxan administration. Neuropathic analgesia was assessed by tail flick, hot plate and tail immersion methods Diabetic mice showed increased plasma glucose concentration, serum nitrite concentration and significant pain hypersensitivity as compared to diabetic mice. Supplementation with ZML extracts, significantly decrease the pain intensity and serum nitrite concentration. The decrease in both pain perception and serum nitrite concentration is more significant with acetone extract of ZML (100 mg/kg and 250 mg/kg). This study provides therapeutic potential of ZML extracts attenuates diabetic neuropathic pain in a dose dependent manner. The exact mechanism of pain relieving is not clear, hence further studies are required to confirm the mechanism of action and responsible chemical constituents for this activity....
The concerned study reveals the experimental investigation of the biological activity of Kandelia rheedei (Family: Rhizophoraceae) used as a traditional antidiabetic and hypolipidemic agent. Research was aimed to study the effect of Kandelia rheedei in both normal and alloxan induced diabetic rats. The ethanolic root extract of Kandelia rheedei at the dose of 400, 600 and 800 mg /kg body weight was administered orally once a day to the groups for 30 days. The fasting blood glucose, cholesterol, HDL cholesterol and serum triglyceride content were estimated in both normal and alloxan induced diabetic rats. The fasting blood glucose, cholesterol and serum triglyceride content were found to be significantly reduced (p<0.05) in treated rats whereas the extract also showed the potent elevation in the level of serum HDL cholesterol. The study reveals that Kandelia rheedei has significant antidiabetic activity and a hypolipidemic activity in alloxan induced and normal fasting rats. The extract seems promising for the development of a phytomedicine for diabetes mellitus....
The present study deals with evaluation of hepatoprotective activity of Pedalium murex (bada gokhru) fruits ethanolic extracts against isoniazide induced hepatotoxicity in rats. Hepatotoxicity in rats was induced by isoniazide (50 mg/kg p.o. for 30 days) and the protective effect of Pedalium murex (200 mg/kg/p.o. and 400 mg/kg/p.o.) was identified by estimating marker enzymes. After 30 days, isoniazide treated rats showed that, there was a significant increment in the level of serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), total bilirubin (TB), triglyceride (TG) and total cholesterol (TC) in isoniazid treated rats compare to normal rats. Rats treated with silymarine and Pedalium murex (400 mg/kg) significantly reduced the elevated level of SGOT, SGPT, TB, TG and TC. Pedalium murex (200 mg/kg) did not show a significant reduction in elevated level of TC. Significant in-vivo antioxidant activity was also found with aqueous alcoholic extract. SOD and Glutathione activity was significantly increased and lipid peroxidation was significantly reduced. The results of the present study had shown that the aqueous ethanolic extract of fruits of Pedalium murex has a good antioxidant and effective hepatoprotective activity. The possible mechanism behind its hepatoprotective activity is its antioxidant activity....
Seeds of Coriandrum sativum have been used in the Indian traditional medicine to relieve stress and other neurological disease conditions. The present study was under taken to evaluate the antidepressant and anxiolytic effects of seeds of Coriandrum sativum Ethanolic Extract (CSEE) in mice. Seeds of Coriandrum sativum ethanolic extract were screened for antidepressant effect by using forced swim test and anxiolytic effect by using locomotor activity at doses of 100 and 200 mg/kg. Distilled water and diazepam were employed as negative and positive control groups, respectively. Antidepressant activity assessment of seeds of Coriandrum sativum ethanolic extract (CSEE) 200 mg/kg shows significantly decrease in immobility time (70.96%) as compared to standard (58.70%) treatment group. While anxiolytic like activity assessment of seeds of Coriandrum sativum ethanolic extract (CSEE) 200 mg/kg shows significantly decrease in locomotion (59.64%) as compared to standard (33.92%) treatment group. The results of this study established a support for the traditional usage of seeds of Coriandrum sativum as antidepressant and anxiolytic medicinal plant....
Peptic ulcer is considered as one of the common diseases in the world. It is a gastrointestinal pathobiological condition due to imbalance between corrosive and restorative factors. Piper attenuatum (B. Ham.) can cure ulcer as mentioned in the literature survey of traditional Indian system of medicine but not proved scientifically so the aim of the present study was to determine the effect of Piper attenuatum (B. Ham.) on aspirin induced gastric ulcer in rats. The rats were divided into four groups each group having four rats. Group 1: Control group; Group 2: Standard group (Ranitidine 20 mg/kg); Group 3: Extract treated group (Piper attenuatum (B. Ham) 200 mg/kg); Group 4: Extract treated group (Piper attenuatum (B. Ham) 400 mg/kg). Ulcer score, ulcer index, ulcer protection, gastric juice volume, free acidity, total acidity and pH were measured. Ethanolic extract of plant shows significant anti-ulcer activity. There were decrease in ulcer score, ulcer index, gastric juice volume, free acidity and total acidity but increase in pH when compare to control group. Aspirin causes gastric ulcer in rats by generating free radicals but ethanolic extract of plant heal ulcer by inhibition of these free radicals and also decrease in biological parameter expect pH....
Shatadhauta Ghrita, an Ayurvedic formulation used for topical application has been accredited with wound healing properties. Panchavalkala (Combination of Five Plant Barks) is also said to be beneficial in promoting wound healing. If both these formulation are gathered together, significant wound healing activity is hypothesized. To validate this, Shatadhauta Ghrita was prepared in presence of Panchavalkala Kwatha and its wound healing activity was evaluated in experimental model. Samples of Shatadhauta Ghrita and Panchavalkala Siddha Shatadhauta Ghrita were prepared by following classical methods and coded as SDG and PSSG. Selected animals were randomly divided into five groups of six animals each. The drugs were applied externally on the excision wound once daily. Betadine was used as reference standard (RS). Both the test drugs showed mild wound healing activity in comparison to RS. The test formulations were found to have mild wound healing activity in excision wound model, the difference in between the test drugs was statistically insignificant....
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