Current Issue : July - September Volume : 2015 Issue Number : 3 Articles : 4 Articles
Thiazole is considered as a biologically important active scaffold that possesses almost all types of biological activities. Successful introduction of ritonavir as a antiviral, cefdinir as a anti-bacterial, pramipexol as a anti-alzheimer dopamine D2-agonist, abafungin as a antifungal drug, sulfathiazole, nifurthiazole as a antimicrobial drug, febuxostat as a hyperuricemic agent, famotidine, cematidine as H2 antagonist and dasatinib as a anticancer and many more species proved potential of thiazole moiety. So far, the modifications of the thiazole ring have proven highly effective and improved potency and lesser toxicity. This diversity in the biological response profile has attracted the attention of many researchers to explore this skeleton to its multiple potential against several activities. This review is complementary work reported on preparation of thiazole and various biological activities of thiazole and its derivatives. Data are presented for active compounds, some of which have passed the preclinical testing stage and some of which are clinically approved....
A series of new imidazolo quinoline analogs AZ-1, AZ-2, AZ-3 and AZ-4 {1-(2-((18Z)-4-substituted benzylidene-4, 5- dihydro-5-oxo-2-phenylimidazol-1-yl) ethyl)-1, 2-dihydro-4-methyl-2-oxoquinolin-7-yl substitutes} were screened for some CNS activities. The observations on general behavioral profile, exploratory behavior {Elevated plus maze (EPM), Light dark apparatus (LDA), Hole board apparatus (HBA), Open field apparatus (OFA) and Marble burrying test (MBT)}, pentylenetetrazole (PTZ) induced convulsions, tail suspension test (TST), forced swim test (FST), haloperidol induced catatonia, hot plate test (HPT), tail immersion test (TIT), pentobarbital induced sleep time and sodium nitrite induced hypoxia were carried out. The mice were administered per orally with test compounds (10, 30 mg/kg) and were compared with the control group. The results indicated that AZ-2 (30 mg/kg) showed anti anxiety effects and potentiated pentobarbital (PB) induced sleep time. The compound may have GABA potentiating effect....
A series of cis-transisomers of stilbene derivatives were synthesised through a chemical reaction named as Wittig reaction between benzyl triphenyl phosphinium chloride with vanillin and anisaldehyde. The structure of the newly synthesized compounds was confirmed by spectroscopic methods i.e. PNMR spectroscopy. The antioxidant activity of the compound is measured against Pseudomonas aeruginoasa, Bacillus subtilis, Staphylococcus aureus, Klebsiella pneumonia, Escherichia coli and ciprofloxacin was taken as standard. VI showed good anti microbial activity against Pseudomonas aeruginoasa, Bacilius subtilis. VI showed good anti microbial activity against Staphyloccocus aureus, E. coli. III shows good anti microbial activity against Klebsiella pnemonia. To the newly synthesised compounds peroxidase activity, reducing property was tested by taking ascorbic acid as standard. For both of these tests the synthesised compounds showed nearly similar increasing activity for all compounds with increasing in the concentration. So I, II, III, IV, V and VI compounds showed similar activity compared to III compound, VI compound showed good peroxidise activity. I, II, III, IV, V and VI compounds showed good reducing property....
Oxazines and Thiazines are highly reactive heterocyclic compounds found to exhibit a wide spectrum of biological activities like analgesic anti-inflammatory, anti-convulsant etc. In the present study an attempt is made to synthesize Oxazines and Thiazines via Chalcones which provide an easy way of synthesis for several heterocyclic derivatives. All these compounds were characterized by means of their IR, 1H NMR, 13C NMR and Mass spectral data. These compounds were evaluated for anti-microbial activity by cup plate method....
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