Current Issue : October - December Volume : 2015 Issue Number : 4 Articles : 5 Articles
Lornoxicam tablets were prepared by conventional wet granulation method using various binding agents. Lornoxicam, a widely prescribed non steroidal anti-inflammatory drug with analgesic properties, belonging to the oxicam class. The objective of the present work was to study the effect of various binding agents on qualities and dissolution rate of lornoxicam tablets. Compressed tablets each containing 8 mg of lornoxicam were prepared using various binders namely acacia, tragacanth, gelatin, xantham gum, HPMC K4M, PVP K30, PVA and MCC. The effects of binding agents on the physical characteristics of lornoxicam granules were studied. The granules were evaluated for angle of repose, bulk density, compressibility index and the tablets were evaluated for content of active ingredient, hardness, friability, disintegration time, dissolution rate. The binder used has significant influence on the tablet and rate of lornoxicam release from the tablets....
The present investigation highlights the formulation, optimization and evaluation of gastroretentive effervescent floating tablets of captopril employing Hibiscus rosa sinensis gum and other polymers like HPMC K4M and HPMC K15M. Captopril, an ACE inhibitor widely used in the treatment of hypertension. Though several floating matrix formers are available, there is a continuous need in the development of novel floating matrix formers which are safe, biocompatible and cost effective. In this regard, present study mainly focussed on the isolation, characterization and evaluation of Hibiscus rosa sinensis gum as a floating matrix former in the formulation of gastroretentive effervescent floating matrix tablets. In order to optimize the concentration of Hibiscus rosa sinensis gum as floating matrix former, 23 factorial design was employed. Formulation was optimized on the basis of floating lag time and T50. The prepared floating tablets were subjected to evaluation for physical characters like hardness, friability, drug content and uniformity, floating lag time, floating time and in-vitro drug release studies. The dissolution data was fitted to kinetic modelling. The optimized formulation followed zero order release model and showed non-fickian diffusion mechanism. The study reveals that concentration of 40% of the Hibiscus rosa sinensis gum can be used as floating matrix former in the formulation of gastroretentive effervescent floating tablets....
The present investigation highlights the formulation, optimization and evaluation of gastroretentive effervescent floating tablets of diltiazem HCl employing tamarind kernel gum. Diltiazem hydrochloride (DTZ) is a calcium channel blocker belonging to the benzothiazepine family, widely used in the treatment of hypertension and angina. Due to its short half life (3.5 h) and absorption in the upper gastrointestinal region, it can be formulated into gastroretentive floating tablets for prolonged release of the drug and better absorption. The objective of the present investigation was to develop a new floating polysaccharide polymer i.e., tamarind kernel gum and optimizing the concentration of it in the formulation of floating tablets, along with the concentrations of the sodium bicarbonate (gas generating agent) and ethyl cellulose (floating enhancer) by using 23 factorial design....
The demand for mouth dissolving tablets has been growing, during the last decade, especially for geriatric and paediatric patients who have swallowing difficulties. Superdisintegrants are responsible to disintegrate the tablet into small particles, which in turn increases the surface area for dissolution, thereby increasing the dissolution rate of poorly soluble drugs. Though a wide range of superdisintegrants are available, there is a continued need to develop new, safe superdisintegrants for fast dissolving tablets. In the present investigation, starch butyrate, a new starch based superdisintegrant was prepared and evaluated for its application in the design of a poorly soluble drug, ketoprofen by employing 23 factorial design....
Fast dissolving tablets are solid dosage forms containing medicinal substances which disintegrate rapidly usually within few seconds when placed upon tongue requiring no additional water to facilitate swallowing. Drug release from these systems is very fast and reproducible as the superdisintegrants play a vital role in the formulation. Superdisintegrants are responsible to disintegrate the tablet into small particles, which in turn increases the surface area for dissolution, thereby increasing the dissolution rate of poorly soluble drugs. Though a wide range of superdisintegrants are available there is a continued need to develop new, safe superdisintegrants for fast dissolving tablets. In the present investigation, starch maleate, a new starch based superdisintegrant was prepared and evaluated for its application in the design of a poorly soluble drug, telmisartan by employing 23 factorial design....
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