Current Issue : October - December Volume : 2015 Issue Number : 4 Articles : 5 Articles
The jaboticaba tree, Plinia trunciflora (O. Berg) Kausel, is popularly named ââ?¬Å?jabuticabeiraââ?¬Â in Brazil and is used in folk medicine to\ntreat diabetes and chronic inflammation of the tonsils, but studies evaluating the central effects of this species are limited. This study\nevaluated the antidepressant-like and antioxidant effects of P. trunciflora (PT) aqueous extract, in which five different anthocyanins\nwere identified. PT showed significant ferric-reduction power and DPPH radical scavenging activity in vitro and reduced lipid\nperoxidation both in vitro and ex vivo. At the behavioural level, PT (400 and 800mg/kg, i.p.) dose-dependently reduced immobility\ntime in the tail suspension test in Swiss male mice. The identification of bioactive compounds accompanied by the in vitro and ex\nvivo antioxidant activity of PT suggests that these activities might be related to the antidepressant-like activity of P. trunciflora....
The antioxidant and antiproliferative activities of the essential oils fromThymbra capitata and Thymus species grown in Portugal\nwere evaluated.Thymbra and Thymus essential oils were grouped into two clusters: Cluster I in which carvacrol, thymol, p-cymene,\n?-terpineol, and Y-terpinene dominated and Cluster II in which thymol and carvacrol were absent and the main constituent was\nlinalool.The ability for scavenging ABTS?+ and peroxyl free radicals as well as for preventing the growth of THP-1 leukemia cells\nwas better in essential oils with the highest contents of thymol and carvacrol. These results show the importance of these two\nterpene-phenolic compounds as antioxidants and cytotoxic agents against THP-1 cells....
Bhasmas are unique metal and mineral preparations of ayurveda. They known in Indian subcontinent for its effectiveness in various chronic ailements in its ash form at small doses. It is assumed that these medicines have superior level of efficacy in comparision to other ayurvedic dosage forms. Bhasmas are contend to produce nanoparticles which are prescribed with other ayurvedic medicines. There are various types of bhasmas i.e metallic and mineral, used with various herbal juices and fruits. Current work aims to generate the all required and important information about bhasmas including their types, method of preparation and some of its reported preclinical testing and theraputic utility. Systamatic review of available literature through official books of ayurveda and other sources indicated that bhasmas are unique ayurvedic preparations used as effective log term theraputic drugs in chronic ailments and its potency influenced by number of factor related with its manufacturing. On the basis of review of litrature, it is concluded that ayurvedic bhasmas (calcinated ash) as medicine have theraputic efficacy greater than other ayurvedic formulations. Bhasmas don’t get metabolised in body, hence exhibiting negligible toxicity....
Coptis chinensis rhizomes (CR) are one important ingredient of traditional Chinese herbal formulas such as San-Huang-Xie-Xin-\nTang which is used for treatment of cardiovascular and neurodegenerative diseases. Recent studies suggest that the extract of CR\nmight be a potential therapeutic agent for amelioration of neurological disorders associated with oxidative stress. In the present\nstudy we aimed at revealing the main active compound(s) of the CR extract and at investigating the mechanism of action. Four\nmain alkaloids of the CR extract (berberine, coptisine, jatrorrhizine, and palmatine) were selected for this study. Results showed\nthat out of those alkaloids only pretreatment with coptisine significantly attenuated tert-butylhydroperoxide induced reduction\nof cell viability, increased rate of apoptosis, and declined mitochondrial membrane potential. Elisa assay and quantitative realtime\nPCR analyses revealed that thioredoxin-interacting protein (TXNIP) gene expression was downregulated by coptisine, which\ncould explain the neuroprotective effect, hypothetically, by strengthening the thioredoxin defense system against oxidative stress\nand attenuation of apoptosis signal-regulating kinase (Ask1) mediated apoptotic signaling. A comparison between coptisine and\nCR extract identified coptisine as themain single component responsible for the neuroprotective effect. Based on the results the CR\nextract and coptisine are promising candidate agents for prevention or improvement of diabetic neuropathy and neurodegenerative\ndisorders....
Background: Anxiety and depression are two of the most prevalence psychological disorders in the world.\nObjective: This study investigates the effects of homeopathic medicine on reducing the symptoms of anxiety and depression.\nMethod: According to the procedure, thirty patients (twenty female and ten male) with the mean age of 45 (range 22-67) were selected randomly and classified in two experimental and controlling groups. The patients were evaluated based on Beck Depression Inventory (BDI) and Spielberger State-Trait Anxiety Inventory (STAI)-Y. The Pretest ââ?¬â?? posttest, and follow-up pattern was designed, homeopathic remedies were used and analysis of covariance with repeated measures is used for data analysis.\nResults: Findings depict significant differences (P<0.01) between two stages of intervention and sustaining of this effectiveness is shown in following-up procedure.\nConclusion: These findings suggest that homeopathic therapy can be used as an effective method to treat anxiety and depression disorders....
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