Current Issue : October - December Volume : 2010 Issue Number : 3 Articles : 6 Articles
Combinatorial synthesis revolutionized the drug industries in this century. After a sequence of procedures parallel generation of molecules carried out and follows high throughput screening assays. Genomic and proteomic studies lead us to design promising molecule that bind in diseased targets. Success in lead discovery requires computational methods, data mining tools and docking procedures. Automated computational technologies reduced time and wastage of money in synthesizing new molecules while whole world is suffering from worst diseases. Building of novel drug is a complex process. In olden days active compounds used in drug discovery programs have been natural products, isolated from plant, animal or fermentation sources. Combinatorial chemistry is one of the important technique developed by researchers in the pharmaceutical industry to minimize the time and costs associated with producing effective and competitive new drugs. By combinatorial chemistry large number of analogues is generated using the same reaction conditions, the same reaction vessels. Traditional synthesis of drug was tedious process which involves one compound at a time....
Some substituted Dibenzo (b, e) azepin - diones were synthesized from 4 - amino acetyl chloride and 2 -amino benzoic acid by total organic synthesis involving three intermediate. All the eights compounds of the series were characterized by spectral data and evaluated against antibacterial and antifungal activity by Agar plate disc diffusion method. The results indicated that the lactum intermediate exhibited comparable antibacterial activity than rest of the compounds whilst others showed good antifungal activity with diminished antibacterial property....
Claisen-Schmidt condensation of 2,4-dihydroxyacetophenone with aromatic aldehydes are carried out efficiently in the presence of magnesium hydrogensulfate under solvent-free conditions in good to excellent yield without the occurrence of any self-condensation. Similar reactions in solution do not proceed satisfactorily. The structures of the synthesized compounds were confirmed by IR, mass spectroscopy and elemental analysis....
The paper emphasized on a new series of mixed ligand co-ordination compound of Palladium having square planner stereochemistry, around the metal ion with the general formula ,[PdL2Cl2] and PdLCl2] where L= uracil and uracil 4 carboxylic acid has been isolated in the solid state by the interaction of with the aforesaid ligands. The synthesized co-ordination compounds have been characterized by elemental analysis, electrical conductance, magnetic measurements, molecular weight determination, electron spin resonance, infra red spectral measurements and NMR studies. A square planner structure has been proposed for square planner complexes. It is observed that:\r\n The synthesized compounds are light brown or brown in colour, non hygroscopic, soluble in DMF, DMSO, slightly soluble in acetonitrile and sparingly soluble in other solvents. The complexes thermally stable and do not decomposed up to 2600C. The complexes have d8 configuration and show anti tumor activity....
2,6 Hydroxy acetophenones were allowed to reactive separately with the various substituted benzaldehydes under solvent free conditions using Silica-sulphuric acid as reagent in an oven. The catalyst silica is reusable and the yields of chalcone are more than 90%. The structures of the synthesized compounds were confirmed by IR, mass spectroscopy and elemental analysis....
In order to develop new antimicrobial agents, a series of Schiff base of Benzimidazole derivative were synthesized and evaluated for their antimicrobial activity. All the synthesized compounds were characterized by IR and 1H-NMR analysis. All compounds exhibited significant antimicrobial activity. The para substituted derivatives were found to be more effective than the ortho substituted derivatives .Compound (VI-d) was found to be the most effective compound against gram positive and negative compounds and also fungi.Compound (VI g and h) were specifically more effective against gram negative bacteria and fungi....
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