Current Issue : April - June Volume : 2010 Issue Number : 1 Articles : 4 Articles
Childhood nephrotic syndrome has a relatively favorable long-term prognosis. The aim of study is to describe the therapeutic measures used for the management of Nephrotic syndrome in pediatrics. A Prospective, non- intervention observational study was conducted at Pediatric Department, SAT Hospital, Govt.Medical College, Thiruvananthapuram. A total of 87 patients satisfying these criteria were enrolled during the visit to in-patient and out-patient department during July 2008 to November 2008. Of the 87 patients, the prevalence of NS was found to be higher in males 62.1%. 27.3% of the patients had 3 months of steroid treatment followed by 6 months 15.6%. Majority of the patients had complication of respiratory tract infection 18.3%. 73.6% patients experienced moon face as the side effect of steroid. 83.9 % of patients are compliant with medicines, 74.9% were compliant with food and 77% compliant with activities. The present study can be considered as a pilot study and further studies regarding its efficacy of drugs used and influence of specific therapy in decreasing relapse frequency can be done...
The symptoms and signs of iron deficiency are partially explained by the presence of anemia. They include pallor, fatigue, poor exercise tolerance, and decreased work performance. Iron, TIBC, Copper, Zinc, Albumin binding capacity of Cobalt, Nickel, Chromium, Manganese, Cholesterol, antioxidant activity of SOD, Catalase and Lipid peroxidation were estimated in two groups. One group containing 40 individuals of age between 40 to 60 years, which served as control and in another group 40 anemic cases of the same age group were considered. The concentration of Hemoglobin significantly decreased (7.77g/dl) in Iron deficiency Anemia. When compared to normal subject (14.55µg/dl). The concentration of Iron was decreased in the anemic cases was about 54.9 µg/dl compared to control which about 163ug/dl and the total iron binding capacity (TIBC) was found to be increased. The TIBC of 40 anemic cases is 210 µg/dl compared to the normal case of about 182 µg/dl. The concentration of copper is increased slightly (173.2µg/dl) when compared to the normal subjects (155.2µg/dl). Zinc concentration has slightly decreased (52.09 µg/dl). The activity of SOD (5858.51 units/g Hb) and catalase (3609.79 units/g Hb) are increased significantly when compared to the control (4736.4 units/g Hb and 4604.64 units/g Hb). Lipid peroxidation concentration was slightly decreased when compared to the normal subject. So we observed that, in anemic subjects, a decline in the level of serum iron and zinc is associated with decreased in the level of lipid peroxidation and increased activity of SOD has been observed....
Punarnavashtak (PN) kwath formulation mentioned in ayurvedic literature “Bhaishyajyaratnavali”, was evaluated for hepatoprotective potential by its in vivo (Paracetamol induced hepatotoxicity) and clinical study to rationalize the traditional use of this formulation for hepatic disorders. Materials and methods: PN kwath was prepared in the laboratory according to the method given in Ayurvedic literature and phytochemical screening was performed to determine the presence of phytoconstituents. Hepatoprotective and antioxidant activity was evaluated against paracetamol induced hepatotoxicity in rats. For clinical study patients with evidence of liver disease attending outpatient clinics were included in a study and underwent the clinical examination and laboratory investigations for liver function tests before commencement of therapy and after eight weeks of treatment with PN kwath. Results: Preliminary phytochemical screening revealed the presence of alkaloids, tannins, flavonoids, saponins and bitter principles in PN kwath. Administration of PN kwath produced significant hepatoprotective effect as demonstrated by decreased level of serum liver marker enzymes such as AST, ALT, ALP, SBRN and an increased protein level as compared to paracetamol treated group. It also showed antioxidant activity by increase in activity of GSH, SOD, CAT and decrease in TBARS level as compared to paracetamol treated group. A comparative histopathological study of liver exhibited almost normal architecture, as compared to paracetamol treated group. Results of clinical study also establish its hepatoprotective potential. Discussion and conclusion: Results from the current study, establishes a good correlation between in vivo and clinical hepatoprotective activity of PN kwath....
Cardiovascular mortality remains the leading cause of death in hemodialysis patients. Inflammation has a role in the development of accelerated atherosclerosis, vascular calcification, malnutrition and anemia. The pleiotropic effect of statins in reducing chronic inflammatory processes of patients undergoing hemodialysis can reduce cardiovascular mortality in dialysis population. The aim of the present study is to demonstrate the effects of low and intermittent doses of simvastatin on inflammatory markers, anemia parameters and lipid profile for hemodialysis patients. Clinically-stable patients undergoing haemodialysis were classified according to their baseline LDL-cholesterol levels in two groups: those with levels below 100mg/dl (Group 1) and those with levels equal to or greater than 100mg/dl (Group-2), and were treated with simvastatin during eight weeks. Group 1 received 20mg only after each session of haemodialysis (intermittent dose), whereas Group 2 received 20mg/daily. Laboratory data, erythropoietin resistance index and nutritional parameters were obtained before and after treatment. A significant reduction in C-reactive protein levels in both groups was observed (50.3 %± 11.7 vs. 34% ± 14.3 p=0.021). In group 1, significant reduction of LDL levels (79.2 ± 13.7 vs. 54.5 ± 18.7, p=0.001), the levels of TG (from 118.2 ± 45.4 mg / dl to 99.8 ± 42.1 mg / dl, p =0.030), and 8.9% for the levels of cholesterol (from 128.5 ± 9.9 mg / dl to 117 ± 12.8 mg / dl, p = 0001).And we observed that there was a significant rise in average 23% for the levels of HDL (from 28.2 ± 4.5 to 36.6 ± 3.7 mg / dl, p = 0001). There was also a tendency towards reduced resistance to erythropoietin (234.3 ± 45 227.2 ± 29.9, p=0.563). It can be concluded that the intermittent doses proved to be as effective as the usual dose in reducing C-reactive protein levels and resistance to erythropoietin and LDL level indicating an important reduction of the cardiovascular risk evaluated by these parameters....
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