Current Issue : January - March Volume : 2016 Issue Number : 1 Articles : 4 Articles
Euphorbia hirta Linn. [Euphorbiaceae; Sp. Pl. (1753)] also called as asthma plant. Traditionally, it is used in the treatment of tumors, fever, asthma, bronchitis, chest congestion, etc. Objective of the study was to evaluate cytotoxicity of methanolic extract of E. hirta using HCT-15 and Vero cell line. MTT assay was used to performed cytotoxicity study of methanolic extract of E. hirta. Doxorubicin was considered as standard drug. Concentrations of extract and doxorubicin were 0.05-1000 µg/ml used. The 50% cell growth inhibition (IC50) of methanolic extract of E. hirta and doxorubicin was 576.82 µg/ml and 460.13 µg/ml against the HCT-15 cell line and 1375.22 µg/ml and 2392.71 µg/ml against vero cell line respectively. Methanolic extract of E. hirta and doxorubicin was effective cytotoxic drugs against HCT-15 cell line and was safe to normal vero cell line. It is due to the extraction of active compounds in the methanolic extract. These are may be new unknown entities or either constituent reported in the earlier studies. Chemical analysis of the extract is in under pipeline. First time author has reported these studies on E. hirta using HCT-15 and vero cell line by MTT assay. This effect can be studied using an allograft and xenograft experimental technique which is not evaluated yet on this plant. Therefore, it is suggested that assessment of active constituents and clinical evaluation of methanolic extract of E. hirta would give a positive lead in the successful treatment of tumors or cancers....
The present study demonstrates the hepatoprotective and antioxidant activity of Benincasa cerifera against alcohol induced hepatotoxicity. In-vivo antioxidant and hepatoprotective activity of aqueous alcoholic extract of fruits of Benincasa cerifera was carried out using alcohol induced liver damage in wistar albino female rats. Significant hepatoprotective activity of methanolic extract was observed in alcohol induced liver damage. All the elevated liver biochemical parameters like serum glutamate pyruvate transaminase (SGPT), serum glutamate oxaloacetate transaminase (SGOT), total bilirubin (TB), direct bilirubin, triglyceride (TG) and total cholesterol (TC) in alcohol intoxicated rats were decreased significantly near to normal level by aqueous alcoholic extract of fruits of Benincasa cerifera. Significant in-vivo antioxidant activity was also found with aqueous alcoholic extract. Superoxide dismutase (SOD), glutathione and catalase activity was significantly increased and lipid peroxidation was significantly reduced. From this study it was concluded that Benincasa cerifera is an effective antioxidant and hepatoprotective herb....
Objective of current research was to determine the thrombolytic activity of the methanolic extract of the whole plant of Ipomoea sepiaria. Till date the plant was not completely explored about phytochemical and phytopharmacological relevance. Hence, this study was planned to evaluate thrombolytic activity of the methanolic extract of the whole plant of Ipomoea sepiaria by whole blood clotlysis method. The methanolic extract of the whole plant of Ipomoea sepiaria showed dose dependant significant thrombolytic activity against standard streptokinase. The study concluded the presence of thrombolytic activity of methanolic extract of this species....
The aim of the present research work was to investigate the wound healing effect of Psidium guajava leaves extract. Psidium guajava Linn (Myrtaceae) has been used as traditional medicine to treat wound. We investigated the wound healing mechanisms of Psidium guajava Leaves Extract. Hydroalcoholic and methanolic extract of Psidium guajava leaves was used. The comparative study of hydroalcoholic and methanolic extract of Psidium guajava leaves was carried out to evaluate wound healing activity. The major findings of the study demonstrated the significant wound healing potential of Psidium guajava leaves extract gel formulation. Clinical healing was established by measuring the area of the wound in each test group on days 3, 6, 9 and 12. Hydroalcoholic extract and methanolic extract containing gel applications result decrease in the wound area in 12 days. Comparative study was done in hydroalcoholic extract and methanolic extract. Hydroalcoholic extract is more effective in comparision with methanolic extract. Histological evaluation showed that the Psidium guajava leaves extract group had a high histological score than the control groups during the whole test period and the difference between the Psidium guajava leaves extract group and the control group was significant. Statistical differences between means were determined by oneway ANOVA followed by Turkey’s test. Values of p<0.040, were considered as significant in this experimental animal study. Formulated herbal gel containing methanolic and hydroalcoholic extract test groups and standerd which indicates that formulated herbal gel was as effective as standard gel for wound healing activity. From the results it was concluded that Psidium guajava leaves extract when formulated in gel show significant improvement in wound contraction and hence this is a promising candidate for wound healing activity. Formulated herbal gel containing methanolic and hydroalcoholic extract test groups and standard which indicates that formulated herbal gel was as effective as standard gel for wound healing activity....
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