Current Issue : April - June Volume : 2016 Issue Number : 2 Articles : 5 Articles
In the present study rats were divided into five groups. Rats of group I (normal control) administered with distilled water only, group II (disease control) treated with distilled water, group III (standard group) treated with ranitidine (50 mg/kg). Group IV and V served as test groups and were administered with Caesalpinia crista extract (CE) in the dose of 250 mg/ kg and 500 mg/ kg orally respectively. All the groups except normal control were administered with cysteamine hydrochloride (CYH) (280 mg/kg) orally. All animals were fasted for the 48 hour before induction of ulcer. During fasting condition, there was free access to water. After 48 hour, cysteamine – HCl is administered three times on day 1st in the dose of 280 mg/kg orally. Standard and the test drugs were administered 30 min prior to the cysteamine treatment. These standard and test drug treatments were continued on 2nd and 3rd day. Rats were sacrificed on 3rd day. All treatments were administered orally. Parameters like ulcer score, ulcer index and % ulcer protection were estimated for evaluation of anti ulcer activity. The aqueous extract of Caesalpinia crista seeds decreased the ulcer score and ulcer index, where as it increased % ulcer protection. These findings suggest that Caesalpinia crista seeds may be effective in preventing duodenal ulcer....
Abutilon indicum Linn. has been used as a traditional medicine in inducing wound healing. In this study, the extracts of the A. indicum leaves were investigated for wound healing activity, in order to obtain an accurate elucidation of its traditional use. Wound healing activity was evaluated by incorporating ethanolic and aqueous extracts in Simple Ointment B.P. using excision wound model, in Albino Wistar rats. Rate of wound healing was calculated at 4, 8, 12 and 16 days after the wounding. Wound healing rates were observed significantly higher in the ethanolic and aqueous extract treated groups than in the control group. The effect produced by the extract ointments, in terms of wound contracting ability and period of epithelialisation were comparable to those of the standard drug framycetin cream. The present study has shown that ethanolic and aqueous extracts of A. indicum leaves possesses wound healing activity and thus provided the evidence in support of its traditional use....
The antioxidant activity of ethanolic extract of Vitex negundo Linn was examined by using DPPH and reducing power assay. The total phenolic contents of the ethanolic leaf extract 39 mg GAE/g and whereas flavonoid contents of these extracts were found to be 0.013 mg RE/g. The ethanol extract shows maximum inhibition (%) of 93.01% as compared to ascorbic acid who shows the maximum inhibition of (%) 93.50% and absorbance of 2.850 and 1.460 in reducing power assay at 1 µg/ml and 0.5 µg/ml respectively. To utilize these significant sources of natural antioxidants, further characterization of the phenolic composition is needed....
1, 2, 3, 9-tetrahydroquinazoline-3, 7-diol was originally isolated from the Tecomaria capensis. It is also known as capehoney suckle belonging to the family Bignonaceae. It (1, 2, 3, 9-tetrahydroquinazoline-3, 7-diol) is a major constituent of the species Tecomaria capensis (Thunb.) Spach. On silica gel GF254 TLC plates the chromatoplate analytical thin layer chromatography was accomplished. It was developed with toluene: ethyl acetate (7:3 v/v) as mobile phase. In this study, isolation of 1, 2, 3, 9-tetrahydroquinazoline-3, 7-diol was achieved by preparative TLC. The compound thus isolated was characterised by Mass, H1 NMR and FT-IR spectral analysis. Mass spectral data shows molecular ion peak of m/z=204.22. Antimicrobial activity was measured against Klebsiella pneumoniae, Staphylococcus subtillis, Escherichia coli and Staphylococcus aureus and anti-inflammatory activity was done in-vitro by using HRBC membrane stabilization method....
Parkinson’s disease (PD) is a progressive extrapyramidal neurodegerative disorder. Oxidative stress has been implicated in the etiology of parkinson’s disease (PD). The important biochemical features of PD, being profound deficit in dopamine (DA) content, reduced glutathione (GSH), enhanced activity of superoxide dismutase (SOD), enhanced lipid peroxidation (LPO) and nitric oxide (NO) in dopaminergic neurons resulting in oxidative stress, mitochondrial dysfunction and apoptosis. Rotenone-induced neurotoxicity is a well acknowledged preclinical model for studying PD in rodents as it produces selective dopamineric neuronal degeneration. The main objective of the present study was to evaluate the neuroprotective effect of Saussurea lappa on rotenone induced parkinsonism in rats. Male wistar rats weighing (150-200 g) were divided into 4 groups with (n=6) in each group. Group I: vehicle treated group, Group II: rotenone group, Group III and Group IV received low and high doses of Saussurea lappa extract all treatments were given for 11 days. On the 13th day behavioral tests were conducted and finally animals were sacrificed and the brain was dissected out for biochemical estimations and histopathology test. In the present study administration of rotenone for 11 days has significantly induced PD by behavioral alterations and biochemical alterarations. Treatment with high doses of Saussurea lappa improved behavioral alterations and biochemical studies revealed the role of Saussurea lappa in preventing the oxidative stress markers. Histopathological studies justified that, treatment with Saussurea lappa extract protected the dopaminergic neurodegeration in nigrostraital pathway....
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