Current Issue : July - September Volume : 2016 Issue Number : 3 Articles : 6 Articles
Jatropha curcus Linn. seeds were extracted using water to obtain aqueous extracts. This extract was evaluated for anticataleptic activity using clonidine induced and haloperidol-induced catalepsy models at the dose of 50 mg/kg, (i.p.). The aqueous extracts (50 mg/kg, i.p.) of the plant significantly inhibited clonidine-induced catalepsy but not inhibited haloperidolinduced catalepsy. The HIC model was used to assess anticataleptic drugs. Inhibition of cataleptic score predicts activity of drug against parkinson's disease. Thus polar constituents of the plant can be used as anticataleptic....
The current study investigated the effect of flavonoid rich fraction of Helicteres isora (Sterculiaceae) fruit for antidiabetic activity. Streptozotocin (STZ) induced Type II diabetic model was used for induction of diabetes mellitus in Sprague Dawley rats. The flavonoid rich fraction of Helicteres isora fruit was administered orally (100, 200, 400 mg/kg b.w) and metformin was used as the standard reference drug. The effect of flavonoid rich fraction of Helicteres isora fruit on body weight, serum glucose, serum cholesterol, serum HDL, serum albumin, serum triglycerides, serum creatinine, serum alkanine phosphatase, serum total protein were estimated in streptozotocin (STZ) induced diabetic rats. A significant decrease in plasma glucose level, serum creatinine level were observed on treatment with 400 mg/kg b.w. of Helicteres isora fruit extract and metformin for 1 week responsible for antidiabetic activity. The ability of the flavonoid rich fraction Helicteres isora (400 mg/kg b.w.) to reduce lipid profile especially triglycerides and low density lipoproteins, cholesterol were represented a protective mechanism against the development of atherosclerosis and atherosclerotic cardiovascular disease complications especially in type-II diabetes mellitus....
Acute oral toxicity study was performed to find out the test dose according to OECD guidelines 425. Ethanolic extract of Sida rhombifolia Linn was found to be safe at a dose of 2000 mg/kg b. w. Anti-stress activity of ethanolic extract was investigated against forced swimming endurance test and chronic cold restraint stress test in rats. Two doses 200 mg/kg and 400 mg/kg b.w p.o of the extract were subjected for the evaluation of anti-stress potential. Diazepam (2 mg/kg b.w p.o) was used as a standard drug. The parameters like plasma cortisol, cholesterol and triglycerides were likely to evaluate the anti-stress activity. Both the lower (200 mg/kg) and higher dose (400 mg/kg) of Sida rhombifolia Linn extract showed dose dependent significant decrease in serum cholesterol, triglyceride and corticosterone. The results obtained were comparable with that of the standard diazepam. The present study concluded that Sida rhombifolia Linn leaves were found to be effective in antistress activity....
Inflammatory bowel disease (IBD) is a spectrum of chronic idiopathic inflammatory intestinal conditions. The aim of present investigation was to evaluate the effect of alcoholic extract of Plectranthus amboinicus in indomethacin induced enterocolitis and acetic acid-induced colitis models of IBD in wistar albino rats. Two doses 200 mg/kg and 400 mg/kg b.w p.o of the Plectranthus amboinicus extract were subjected for the evaluation of treatment of IBD activity against the IBD induced by indomethacin (7.5 mg/kg, s.c) and acetic acid (2 ml 4% intrarectally) in rats. Prednisolone, 2 mg/kg, p.o was served as standard in both the models. The parameters studied includes measurement of physical parameters; change in body weight and colon weight, estimation of biochemical parameter; myeloperoxide and lipid peroxides, macroscopic evaluation; scoring of ulcers and microscopic evaluation; histopathology. The pretreatment with alcoholic extract of Plectranthus amboinicus at a dose of 200 and 400 mg/kg, p.o. and standard group of animals significantly (P < 0.01 and P < 0.001 respectively) and dose dependently attenuated results in all above said parameters when compared to disease inducing group. Histopathological study supports the above results by protective and regeneration effects on colonic cells by Plectranthus amboinicus pretreatment. The results obtained were comparable with that of the standard....
Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by a progressive dementia affecting cognition, behavior and functional status of a person. Recent studies suggest that free radicals play a key role in the pathology of AD by inducing lipid peroxidation and neuronal death. Linseed oil is a potent antioxidant and is believed to have beneficial effects. However, no study has been reported on neuroprotective effect of linseed oil on aluminum chloride induced Alzheimer’s disease in rats. Male wistar rats weighing (150-200 g) were divided into 5 groups of 6 animals each. Group 1 (normal control): Received distilled water orally for 30 days. Group 2 (disease control): Received aluminium chloride (25 mg/kg p.o) for 30 days to induce experimental Alzheimer’s disease. Group 3 (standard group): Received aluminium chloride + standard donepezil (10 mg/kg p.o) for 30 days. Group 4 (disease treated group): Received aluminium chloride + low dose of linseed oil (1 ml/kg p.o) daily for 30 days. Group 5 (disease treated): Received aluminium chloride + high dose of linseed oil (2 ml/kg p.o) daily for 30 days. Behavioral tests were conducted at every week such as open field test, elevated plus maze test, T-maze test, modified elevated plus maze test and rotarod test. On 31st day, the animals were sacrificed by giving thiopental sodium. The brain was isolated for biochemical estimations such as acetyl cholinesterase, super oxide dismutase (SOD), malondialdehyde (MDA), reduced glutathione (GSH), nitrate level, total proteins and histopathology. The present study suggests that, linseed oil may show beneficial effects in treating Alzheimer’s disease. This activity may be due to its antioxidant and anticholinesterase effects. The neuroprotective effect of linseed oil on aluminium chloride induced AD might be associated with its AchE activity and free radical scavenging activity....
The present investigation aims to elucidate the possible protective effect of flavonoid rich methanolic extract of S. scaphigera in acetic acid induced ulcerative colitis in male wistar rats. Male wistar rats were divided into various treatment groups. The animals were administered 2 ml of acetic acid (4% v/v) via intrarectal route to induce colitis. Prednisolone (2 mg/kg, p. o.) was used as a standard drug and S. scaphigera was administered at a dose of 100 and 300 mg/kg, p. o. macroscopic scoring, relative organ weight, colonic superoxide dismutase (SOD), catalase (CAT), reduced glutathione (GSH), lipid peroxidation levels (LPO) and histopathological changes were recorded after the treatment regimen of 11 days. Intrarectal instillation of acetic acid caused significant (p<0.05) increase in relative organ weight and LPO levels and significant (p<0.05) decrease in the levels of SOD, CAT and GSH levels. Histopathological changes in the colonic tissue were noted as transmural necrosis, edema and diffuse inflammatory cell, infiltration in the mucosa and loss of epithelium. Pretreatment with S. scaphigera (100, 300 mg/kg, p. o.) exhibited significant (p<0.05) reversal of all the above biochemical parameters and significantly reversed the histopathological changes induced by acetic acid treatment. The present investigation demonstrated the potent therapeutic value of S. scaphigera (100 and 300 mg/kg, p. o.) in the amelioration of experimental colitis in rats. The beneficial effects of S. scaphigera could be attributed to its antioxidant effect....
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