Current Issue : July - September Volume : 2016 Issue Number : 3 Articles : 5 Articles
Dry eye disease is a relatively common ocular problem, which causes eye discomfort and visual disorders leading to a decrease in\nthe quality of life.The aim of this study was to find a possible excipient for eye drop formulations, which is able to stabilize the tear\nfilm. A cationic thiolated polyaspartamide polymer, poly[(N-mercaptoethylaspartamide)-co-(N-(N',N'-dimethylaminoethyl)aspartamide)]\n(ThioPASP-DME), was used as a potential vehicle. Besides satisfying the basic requirements, the chemical structure of\nThioPASP-DME is similar to those of ocular mucins as it is a protein-like polymer bearing a considerable number of thiol groups.\nThe solution of the polymer is therefore able to mimic the physiological properties of the mucins and it can interact with the mucus\nlayer via disulphide bond formation.The resultant mucoadhesion provides a prolonged residence time and ensures protective effect\nfor the corneal/conjunctival epithelium. ThioPASP-DME also has an antioxidant effect due to the presence of the thiol groups. The\napplicability of ThioPASP-DME as a potential excipient in eye drops was determined by means of ocular compatibility tests and\nthrough examinations of the interactions with the mucosal surface.The results indicate that ThioPASP-DME can serve as a potential\neye drop excipient for the therapy of dry eye disease....
The present research work aimed at evaluation of Tara gum (TG) as a controlled release and mucoadhesive agent in buccal tablets. Buccoadhesive tablets were formulated with an intention to avoid hepatic first-pass metabolism and also to enhance residence time in the buccal cavity. TG was procured from the market and characterized for various physiochemical parameters as well as for its adhesive properties. Tablets were prepared containing TG and chlorpheniramine maleate (CPM) as a model drug, using direct compression technique. Nine different formulations were prepared and evaluated containing three mucoadhesive components namely Carbopol 974P, Methocel K4M and TG (25 mg, 50 mg and 75 mg). The results of the study indicated that the TG had good physicochemical and morphological characteristics. Tablets conformed to the Pharmacopoeial specifications and in-vitro release studies showed the controlled action of drug with increasing concentration of the TG in the formulations. Permeability studies revealed that drug permeation was increased with the increase in the concentration of the mucoadhesive polymer. FTIR and UV spectroscopy studies between gum and CPM suggested the absence of chemical interaction between CPM and TG. The formulated mucoadhesive tablets for buccal administration containing natural TG (TGF3) have a potential for the controlled action of drug release. Thus, buccoadhesive tablets for controlled release were successfully formulated using natural gum....
The present work is concerned with the formulation of oral dispersible tablets of escitalopram by using natural and synthetic superdisintegrants. Escitalopram is an anti-psychotic drug comes under BCS-II which has low solubility and high permeability. The solubility of the dug can be increased by complexation. Inclusion complexes of escitalopram with β- cyclodextrin have been prepared in the ratio of 1:1, 1:3 and 1:5 and the inclusion complexes containing 1:3 has shown 87% increased aqueous solubility when compared with pure drug. Preformulation studies like solubility, melting point, drug- carrier interaction studies were conducted. FTIR studies reveals no interaction between drug and carrier. In this study, natural super disintegrating agent used was dehydrated banana powder and synthetic one is crospovidone. Six formulations were prepared using different concentrations of superdisintegrants like dehydrated banana powder and cross povidone by using direct compression method. All the formulations were evaluated for precompression tests like bulk density, tapped density, hausners ratio and Carr’s index and all the parameters were found to be within the pharmacopoeial limits. Post compression parameters like hardness, thickness, disintegration time and in-vitro drug release studies were performed. Formulation M3 containing 10% w/w of dehydrated banana powder has shown disintegration time of 20 sec and 97% of drug release within 25 minutes. The formulation M6 containing 10% w/w of cross povidone has shown disintegration time of 18 sec and 94% of drug release within 20 minutes....
Natural excipients have become immensely popular in recent time for the development of variety of novel drug delivery systems. Researchers are showing keen interest in natural excipients like gums and mucilages for the betterment of conventional drug delivery systems as well as formulation and development of novel drug delivery systems. The reason for their popularity over synthetic polymers includes advantages like non toxicity, biodegradable nature, economical, chemically inert in nature and easy of availability. The ability to modify biopolymers and excipients to achieve desirable qualities make them even more attractive materials in development of novel drug delivery systems. Many such polymers have been tried and tested in development of buccal mucoadhesive drug delivery systems. The unique route of drug administration directly into systemic circulation is a very good alternative for oral conventional drug delivery systems. Various biopolymers possess mucoadhesive properties and matrix forming capabilities which is most basic requirement for the formulation development of any buccal mucosal drug delivery systems. Biopolymers are capable to act as a rate retarding polymers and thus help to achieve sustained release of drugs over the period of time. In this review an attempt has been made to discuss some of the most important natural excipients investigated in development of buccal mucoadhesive drug delivery systems....
The purpose of this study was to offer a new insight into the microstructure changes during in vitro lipolysis of five lipid-based\ndrug delivery formulations belonging to different lipid formulation types. Five lipid-based formulations of indomethacin were\ninvestigated using an in vitro lipolysis model. During lipolysis, microstructures of the intermediate phase formed by lipolytic\nproducts were observed.The results showed that the time of liquid crystal formation during in vitro digestion for these formulations\nwas Type I > Type II > Type IIIB > Type IV > Type IIIA (...
Loading....