Current Issue : January - March Volume : 2017 Issue Number : 1 Articles : 5 Articles
Various synthetic derivatives of natural flavonoids are known to have neuroprotective properties. Rutin is a flavonoid\nthat is an important dietary constituent of food and plant-based beverages having anticonvulsant effect. In view of this, the\npresent study was designed to investigate effect of rutin on pentylenetetrazole (PTZ) kindling induced depression in mice using\nforced swim test. PTZ (35 mg/kg) was administered on alternate days to produce kindled mice. Kindled mice were treated with\n50, 75 and 100 mg/kg of rutin daily and on PTZ administration day 30 min before PTZ. Mean seizure stages were assessed in\nPTZ kindling and these kindled mice were observed for immobility time period in forced swim test for evaluating depression.\nThe results suggest that pre-treatment with rutin at 50, 75 and 100 mg/kg can attenuate seizure severity during the kindling\nprocedure. Additionally, rutin administration significantly decreased the immobility time period in the forced swim test in a\ndose dependant manner. The results of present study concluded that rutin suppress PTZ kindling induced seizures and\nameliorates depression induced by PTZ kindling in mice....
Acetylcholinesterase (AChE) inhibitors are the best available pharmacotherapy for the treatment of various\nneurological disorders such as Alzheimerâ��s disease, senile dementia, ataxia, myasthenia gravis, glaucoma and paralytic ileus.\nEllmanâ��s method is widely used in-vitro method for evaluation of AchE inhibitory. Hexane subfraction from methanolic extract of\nN. jatamansi was prepared by soxhlet extraction method. AchE inhibiton assay of hexane subfraction of N. jatamansi showed\nbetter IC50 - 36.41 �¼g/ml. Hexane subfraction was subjected to column chromatography and each fraction was evaluated for the\nAchE inhibitory activity. Amongst 12 Column fractions C9, C11 and C12 showed 61.39%, 58.08% and 62.94% AchE inhibitory\nactivity respectively. The % inhibition of AChE enzyme by above three fractions was less than the % inhibition of hexane\nfraction, which indicates that AchE inhibitory activity of hexane fraction is not due to any single compound but it is synergistic\nactivity of several compounds present in the hexane fraction....
The present research work was focussed on preparation as well as the evaluation of ethanolic extract of Argemone\nmexicana plant for ex-vivo anti-cholinergic activity. Herbal medicines are well known for their therapeutic benefit. Argemone\nmexicana, a xerophytic plant has several medicinal properties like diuretic, anti-inflammatory, anthelmintic, analgesic, etc. The\nethanolic extract was prepared by soxhelation. The ethanolic extract at graded concentrations was evaluated for ex-vivo anticholinergic\nactivity in the presence of acetylcholine using isolated chick ileum. A decrease in response was observed when\nArgemone plant extract was given along with acetylcholine. These results were compared with that of the standard anticholinergic\nagent, atropine. Thus from the present study it was concluded that the ethanolic extract of Argemone mexicana could\nbe a promising anti-cholinergic agent which would be a boon in treating hypertensive and spasmodic patients....
Mimosa tenuiflora is reported widely used in diabetes, chest pain as an analgesic, anti-inflammatory and healing of wounds in folk medicine. This study was therefore partly aimed at investigating ex-vivo possible AChEI activity and ex-vivo wound healing activity. Cholinesterase inhibitory therapy serves as a strategy for the treatment of Alzheimer’s disease (AD). The angiogenic activity of methanolic extract of M tenuiflora plant was studied using chorioallantoic membrane (CAM) model (in-vitro) in 9 days old fertilized chick eggs. M tenuiflora had shown to be a rich source for new and promising agents (AChEIs) for the treatment of AD. The extract found to promote angiogenesis as evidenced in CAM model, presenting increasing number of capillaries on the treated CAM surfaces, which might be beneficial in the treatment of wound healing....
The present study aims to explore the neuroprotective role of methanol extract of Cordia dichotoma (MCD) in the cerebral ischemia-reperfusion induced injury in mice. Swiss Albino mice (either sex), weighing between 18-30 g were used in this study. Animals were divided in 6 groups (n= 6-8). Bilateral carotid artery occlusion for 10 min followed by reperfusion for 24 h was employed in the present study to produce ischemia and reperfusion-induced cerebral injury in mice. Short-term memory was evaluated using the elevated plus maze test and rotarod apparatus was used to assess motor incoordination. MCD was administered in 3 doses (125, 250 and 500 mg/kg; p.o.) to mice for 7 successive days daily before surgery. Edaravone (3 mg/kg, i.p.) was used as standard drug. Animals were sacrificed after all behavioral parameters and 24 hr after surgery for biochemical estimations (TBARS, GSH, SOD, catalase and total brain protein estimations). Ischemia-Reperfusion-injury induces decrease in motor-co-ordination and memory of mice. Further ischemic mice showed higher brain TBARS and lowered GSH, SOD and catalase levels. MCD (500 mg/kg/p.o.) administration significantly attenuated (p<0.05) the behavioral and biochemical alterations produced by ischemia-reperfusion-Injury. Thus, MCD may prove to be useful remedy for the management of cerebral ischemia owing to its potent antioxidant properties....
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