Current Issue : January - March Volume : 2017 Issue Number : 1 Articles : 5 Articles
The novel series of pyrazole carboxamide derivatives were prepared by the various ketene dithioacetals condensed\nwith hydrazine hydrate under microwave irradiation. All the synthesized compounds have been characterized by using\nelemental analysis, FT-IR, 1H NMR, 13C NMR spectroscopy and further supported by mass spectroscopy. Purity of all the\ncompounds has been checked on thin layer chromatographic plate and HPLC technique. All the synthesized compounds were\ntested for their antimicrobial, analgesic and anti-inflammatory activities. The compounds exhibited significant antimicrobial,\nanalgesic and anti-inflammatory activities. These compounds can be further exploited to get the potent lead compounds. The\ndetailed synthesis, analgesic, anti-inflammatory and antimicrobial screening of the new compounds are reported....
The present study refers to the synthesis of new antidepressant candidates using the pyrazoline scaffold. In an\nattempt to identify potential lead antidepressant agents, a number of N-((3-(4-chlorophenyl)-5-phenyl-4,5-dihydro-1H-pyrazol-\n1-yl)methyl)-substituted amine (mannich base) were synthesized by microwave assisted synthesis. The antidepressant activity\nof the synthesized compounds (3aââ?¬â??3h) was evaluated by forced swim test (FST) and tail suspension test (TST). The present\nwork showed significant antidepressant activity for all compounds, of the series compounds (3e) and (3g) were found to be\npotent molecules of this series when compared with the reference drugs imipramine and fluoxetine. Thus, these compounds can\nserve as potential leads for further antidepressant studies....
In this work, we have synthesized thirteen (SB1-SB13) Schiff bases derived from condensation reaction of pyrrole-2-carboxaldehyde with different aniline derivatives. The structures of the synthesized products were confirmed by physicochemical and spectral (IR and 1H NMR) means. These compounds were screened for their antimicrobial activity against five bacterial and two fungal strains and their activity was compared with standard drugs ciprofloxacin and fluconazole respectively. Among all the synthesized derivatives, SB7 was found to be more active compared to the other synthesized derivatives but less than the standard drugs....
Fifteen thiophene-2-yl pyrimidine derivatives were synthesised by a reported procedure. The first step of reaction is\nreacting 2-acetyl thiophene and substituted aromatic aldehydes to prepare chalcones. The second step is preparation of\npyrimidines by reacting guanidine hydrochloride with chalcones. Third step is formation of Schiff base from pyrimidines. Final\nstep is preparation of thiophene-2-yl triazolo pyrimidine derivatives by reacting Schiff base with hydrazine hydrate. Their\nstructures were confirmed by IR, 1H NMR. TLC of synthesized compounds performed in chloroform: ethanol (3:1) solvent\nsystem. The anti-inflammatory activity of all compounds has been recorded on the basis of reference standard indomethacin. All\nthe compounds showed tendency to cause a fall in oedema and showed anti-inflammatory activity. Anti-inflammatory activity of\nall compounds was taken by carrageenan induced rat paw oedema on albino rat....
Podophyllotoxin belongs to the cyclolignan family of natural products. It exhibits cathartic, cytotoxic, antimitotic,\nanticancer and other biological activities. The new podophyllotoxin analogues were synthesized in very good yields by heating\n3, 4, 5-trimethoxybenzaldehyde, succinic anhydride and amine derivatives in ethanol at 60�°C. All the products were\ncharacterized by spectral and elemental analysis data....
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