Current Issue : July - September Volume : 2017 Issue Number : 3 Articles : 5 Articles
Flavanones are polyphenols found in citrus fruits (lemons, grapefruits and oranges). They are so bioavailable that they can appear in blood plasma as soon as 20 minutes after ingestion, though their concentrations aren’t maximized until after about four hours. This makes flavanones a significant contributor to the antioxidant pool that circulates in your blood. However, since these flavanones are completely excreted after 24 hours, it’s beneficial to consume foods that contain them, such as citrus fruits, on a daily basis. Antioxidants help our body repair cells damaged by free radicals. The most common antioxidants are beta-carotene, lycopene and vitamins A, C and E. Antioxidants can also be found in fruits, vegetables and teas. Flavanone has been used widely for their antimicrobial and antifungal property. We synthesized 1-[2-(furan-2-yl)-2,3-dihydrochromen-4-ylidene]-4-phenylsemi-carbazone (Y2i). The derivative was characterized by Physico-chemical (TLC and Melting Point) and spectral analysis (I.R., N.M.R and Mass Spectroscopy) and finally the biological activities were performed by using different animal models like pentylenetetrazole-induced convulsions in rats for anti-convulsant activity, tail immersion method for analgesic activity and paw edema method for anti-inflammatory activity respectively and compared with the standard drug diazepam and diclofenac sodium. Compound Y2i (2-(furan-2-yl) OR (o-furfuryl) substitution was found to have more significant results as comparable to standard drug diazepam and diclofenac sodium respectively. The title compound was also screened for in-vitro antimicrobial activity by cup-plate method and compound Y2i was found to have significant results against all the bacterial strains and the fungal strain as compared with streptomycin and fluconazole....
We synthesized some novel flavanones incorporated semicarbazide derivatives (Y2e–Y2j). The derivatives were characterized by physico-chemical (TLC and melting point) and spectral analysis (I.R., N.M.R and mass spectroscopy) and finally the biological activities were performed by using different animal models like pentylenetetrazole-induced convulsions in rats for anti-convulsant activity and tail immersion method for analgesic activity respectively and compared with the standard drugs diazepam and diclofenac sodium. Compound Y2g, Y2h, Y2j i.e., ({4-(dimethylamino)phenyl}, {2-phenyl-2,3-dihydro} and 4-hydroxy-3-methoxyphenyl) and Compound Y2e, Y2f, Y2g i.e., (4-nitrophenyl, 4-hydroxyphenyl, [4-(dimethylamino)phenyl] ) substitution was found to have more significant results as comparable to standard drug diazepam and diclofenac sodium respectively. A flavanone found in orange juice, may significantly reduce blood pressure and other cardiovascular disease risk factors. Moreover number of studies has shown a protective effect of polyphenol-rich foods, including tea, wine and chocolate against cardiovascular diseases (CVDs)....
A series of 1,3,4-oxadiazole and pyrazole derivatives have been synthesized and evaluated for anti-inflammatory activity. The structures of synthesized compounds were confirmed by IR, 1H NMR, Mass and CHN analysis. These compounds have shown promising antiinflammatory activity when compared with the standard drug indomethacin....
A convenient, accessible, and high yield method for preparing of 6-methyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one (1) by\ntreatment of acetoacetic acid ethyl ester with thiourea in sodiummethylate was developed.Thealkylation of the latter with 3-chloropentane-\n2,4-dione and further regioselective cyclization of intermediate compound (2) in high yield afforded 2-acetyl-3,7-dimethyl-\n5H-thiazolo[3,2-a]pyrimidin-5-one (3). The halogenation and some transformations of synthesized thiazolo[3,2-a]pyrimidine (3)\ndue to its ketone group were carried out to obtain the corresponding carboxamide, carbothioamide, sulfonohydrazide, and oxime\nand its alkylated derivatives (5). At preliminary biological studies the synthesized compounds have shown growth stimulant\nproperties. The activity of four of them was higher than 70%, compared with heteroauxin....
A new series of 3-(methylthio)-1-phenyl-1H-pyrazolo[3,4-d]pyrimidine derivatives\nwas synthesized. The structures of the new derivatives were confirmed by\nthe spectral data and elemental analyses. The antitumor activity of this series\nagainst human breast adenocarcinoma cell line MCF7 was evaluated. Out of\ntwenty new derivatives, ten were revealed mild to moderate activity compared\nwith doxorubicin as a reference antitumor. Among this new series\nN-(2-chlorophenyl)-2-(3-(methylthio)-4-oxo-1-phenyl-1H-pyrazolo[3,4-d]py\nrimidin-5(4H)-yl)acetamide (13a) was found the most active one with IC50\nequal to 23 �¼M....
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