Current Issue : April - June Volume : 2017 Issue Number : 2 Articles : 5 Articles
Most of the pharmaceuticals are administered by the oral route which is the popular route of\ndrug delivery. Taste is an essential and critical parameter in administering formulations which\nhave relation with taste buds. Several drugs have bitter taste, consequently there is a consistent\nproblem in the treatment of the patients because of their inability to swallow such formulations.\nFour formulations of taste masked granules of clarithromycin were thus prepared by wet\ngranulation and enteric-coating techniques using different concentrations of taste masking agent\nand two coating materials. The resulting clarithromycin granules were characterized for size\ndistribution, content determination, dissolution at phosphate buffer (pH 6.8), release in 0.1N HCl\nand taste evaluation. Among these formulations, Formulation D showed minimum bitterness,\nbetter dissolution profile at phosphate buffer at pH 6.8 and higher resistance to the acidic\nmedium comparing to other formulations. The formulation D presented showed to be a good\nbase for preparing an oral reconstitutable suspension, which was evaluated for various parameters\nlike drug content, dissolution at phosphate buffer at pH 6.8 and taste evaluation. The oral taste\nmasked suspension prepared disposed respectable decline in the sour taste of clarithromycin and\nsimilar dissolution profile in comparison with marketed suspension....
Chitosan and Carbopol have been used to form a complex through an electrostatic interaction between the protonated amine\n(NH3+) group of chitosan and the carboxylate (COOâË?â??) group of Carbopol. In situ polyelectrolyte complexes formations based\non the physical mixture of chitosan and sodium alginate were found and could be used as an oral controlled release matrix. The\naim of this work is the assessment of a possible interaction between the particles of chitosan and Carbopol 974P NF that could\nmodify their technological performance in captopril tablets. The drug and excipients were evaluated as mixtures of powders and\ntablets. The mixtures with captopril contained Carbopol 974P NF, chitosan, or a 1 : 1 mixture thereof with polymer proportions of\n10%, 20%, and 30%. The evaluated parameters were the powder flow rate, the powder compressibility index, and the compactibility\nand release behavior of the tablets. The observed technological behavior points out to a greater interaction between the particles of\npolymers with different charge than between particles of the individual polymers. This produces more coherentmatrices restricting\nmore efficiently the drug dissolution, more coherent tablets with higher compactibility, and less flowing powder mixtures. All this,\nhowever, requires additional investigation to confirm the current results....
Novel poly-(3-hydroxybutyrate)-based systems for controlled release of anti-inflammatory drug has been studied.\nIbuprofen diffusion processes determine the rate of the release at the early stages of the contact of the system with the\nenvironment (the first 6ââ?¬â??8 h). The coefficient of the release diffusion of a drug depends on its nature, the thickness of the poly-\n(3-hydroxybutyrate) films containing the drug, the concentrations of ibuprofen and the molecular weight of the poly-(3-\nhydroxybutyrate). The technique of central composite design (CCD) was used to map the optimal composition range for process\nparameters; this technique is mainly used to map the optimum ER Tablets. PHB base ER tablet of ibuprofen was prepared by\ndirect compression technique and characterized by physicochemical parameters. The prepared tablets were evaluated for\nphysical properties hardness, friability, disintegration time and in-vitro drug release. The drug release pattern, kinetic profiles as\nwell as the low rate of IF release from the tablet was in satisfactory agreement with kinetics of weight loss measured in-vitro for\nthe PHB Tablet. PHB based Ibuprofen oral extended release tablet successfully extended the ibuprofen release in comparison\nwith HPMC....
Purpose: To investigate and compare the physicochemical properties and lubricant potentials of Blighia\nsapida seed oil (BSSO) with those of magnesium stearate, a commercial lubricant.\nMethods: The dried seeds of Blighia sapida (BS) powder were macerated with n-hexane for five days\nto separate the oil. The physicochemical properties; solubility profile, acid value, saponification value,\niodine value of the oil were determined using standard methods. Batches of ascorbic acid tablets\ncompressed at same compression settings using different concentrations of BSSO as lubricant were\nevaluated for their friability, weight uniformity, tablet hardness, disintegration and dissolution.\nResults: BSSO had a density of 0.9 g/ml, acid value of 2.65 �± 0.20 mg KOH/g, saponification value of\n141.65 �± 0.75 mg KOH/g, iodine value of 62.50 �±3.71 mg I2/g among other parameters. Fatty acid\nmethyl ester analysis (FAME) revealed 96.89 % of monounsaturated fatty acids and esters in the range\nof C15-C23; a C23 compound, 22-tricosenoic acid was the dominant compound (46.82 %). The oil showed\nexcellent lubrication properties in ascorbic acid tablets at a low concentration (0.5 %), similar to 2 %\nmagnesium stearate. However, higher concentration (5 %) of BSSO resulted in granules that could not\nbe compressed into tablets. Tablets containing BSSO demonstrated satisfactory friability, weight\nuniformity, hardness, disintegration and dissolution characteristics.\nConclusion: Blighia sapida seed oil is a potentially useful low-cost tablet lubricant. However, further\ninvestigations on the excipient, including stability, toxicity, etc, are required to ascertain its suitability....
The effect of the hydrophilic polymers such as sodium carboxymethyl cellulose, (NaCMC) and the hydrophobic polymers such\nas Eudragit RL100 and Eudragit RS 100 on the dissolution and the release rate of drug when prepared as controlled release\nmatrices were studied. Tablets were prepared by a direct compression technique. The dissolution tests were performed by both\nthe basket and the paddle methods. In the present study the acrylic resins Eudragit RS 100 and Eudragit RL 100 are separately\nmixed with the anionic and hydrophilic polymer NaCMC and the other excipients in an attempt to prepare controlled release\nmatrices and to investigate the effect of the charge and composition of these polymers on the drug release. Also the research\nwill study the effect of the pH of the dissolution medium, and the storage of the matrices at different temperatures, on the\nrelease rate of the drug. It was found that percent, charge of the polymers, pH of the dissolution medium and storage of\nmatrices at different temperatures affect the release rate of the drug. The experiments were performed in vitro and the data\nobtained were plotted according to four kinetic models to study the release kinetic. These models were zero order release, first\norder release, Higuchi equation, and Korsmeyer equation. Zero order release was observed in the formulation with a high\npercent of the hydrophilic polymers, while high percent of hydrophobic polymers didn�t show zero order release and the drug\nwas liberated in a less time from the matrices....
Loading....