Current Issue : January - March Volume : 2018 Issue Number : 1 Articles : 5 Articles
The present article provides a novel technique for the co-amorphous formation of acyclovir and oxalic acid as an\nexcipient. Designated as ACV-oxalic acid, methods for the preparation thereof and its use in pharmaceutical\napplications are described. The co-amorphous ACV-oxalic acid was characterized by powder X-ray diffraction,\ndifferential scanning calorimetry and thermogravi metric analysis. Stability with respect to relative humidity (RH) for\nthe co-amorphous ACV-oxalic acid was evaluated and compared with the parent ACV. The aqueous solubility of the\nco-amorphous ACV-oxalic acid was significantly improved (about 8 times more soluble) at 35�°C compared to that of\nthe parent Acyclovir base....
Topical delivery of gabapentin is desirable to treat peripheral neuropathic pain conditions\nwhilst avoiding systemic side effects. To date, reports of topical gabapentin delivery in vitro have\nbeen variable and dependent on the skin model employed, primarily involving rodent and porcine\nmodels. In this study a variety of topical gabapentin formulations were investigated, including\nCarbopol�® hydrogels containing various permeation enhancers, and a range of proprietary bases\nincluding a compounded Lipoderm�® formulation; furthermore microneedle facilitated delivery was\nused as a positive control. Critically, permeation of gabapentin across a human epidermal membrane\nin vitro was assessed using Franz-type diffusion cells. Subsequently this data was contextualised\nwithin the wider scope of the literature. Although reports of topical gabapentin delivery have been\nshown to vary, largely dependent upon the skin model used, this study demonstrated that 6% (w/w)\ngabapentin 0.75% (w/w) Carbopol�® hydrogels containing 5% (w/w) DMSO or 70% (w/w) ethanol\nand a compounded 10% (w/w) gabapentin Lipoderm�® formulation were able to facilitate permeation\nof the molecule across human skin. Further pre-clinical and clinical studies are required to investigate\nthe topical delivery performance and pharmacodynamic actions of prospective formulations....
The disintegrant potential of native starches of five new cassava (Manihot esculenta Crantz.) varieties developed by the Crops\nResearch Institute of Ghana (CRIG) was studied in paracetamol tablet formulations. The yield of the starches ranged from 8.0\nto 26.7%. The starches were basic (pH: 8.1ââ?¬â??9.9), with satisfactory moisture content (ââ?°Â¤15%), swelling capacity (ââ?°Â¥20%), ash values\n(<1%), flow properties, and negligible toxic metal ion content, and compatible with the drug. The tensile strength (...
Although rosemary essential oil (EO) shows many biological activities, its topical benefits\nhave not been clearly demonstrated. In this work, we assessed the effects on skin hydration and\nelasticity of rosemary EO after topical application via gel vehicles in human volunteers. To improve\nits topical efficacy, rosemary EO was loaded into lipid nanoparticles (NLCs) consisting of cetyl\npalmitate as a solid lipid, and non-ionic surfactants. Such NLCs were prepared using different ratios\nof EO/solid lipid and those containing EO 3% w/w and cetyl pamitate 7% w/w were selected for\nin vivo studies, showing the best technological properties (small particle size, low polydispersity\nindex and good stability). Gels containing free EO or EO-loaded NLCs were applied on the hand\nskin surface of ten healthy volunteers twice a day for one week. Skin hydration and elasticity\nchanges were recorded using the instrument Soft Plus. Gels containing EO-loaded NLCs showed\na significant increase in skin hydration in comparison with gels containing free EO. Skin elasticity\nincreased, as well, although to a lesser extent. The results of this study point out the usefulness of\nrosemary EO-loaded NLCs for the treatment of cutaneous alterations involving loss of skin hydration\nand elasticity....
Hot melt extrusion (HME) is considered an efficient technique in developing solid molecular\ndispersions, and has been demonstrated to provide sustained, modified and targeted drug delivery\nresulting in improved bioavailability. However, most commercial enteric or pH-responsive polymers\nare relatively difficult to process or have high Glass Transition Temperature (Tg) values, making their\nuse with temperature-sensitive drugs, probiotics or biologics not viable. Shellac is a natural\nthermoplastic, and after a review of current literature on the pharmaceutical HME process, a possible\ngap in the knowledge of the use of shellac to produce dosage forms by means of HME was identified.\nThis work explores the possibility of SSBÃ?® 55 pharmaceutical-grade shellac as a melt-extrudable\nencapsulation polymer to entrap freeze-dried probiotic powder and to determine bacterial cell\nviability post-processing. Well-defined strands were produced from the physical mixture of shellac\nand BiocareÃ?® Bifidobacterium Probiotic. FTIR clarified that there are no significant interactions\nbetween the probiotic and polymer. All of the samples demonstrated less than 5% degradation over\n24 h at pH of both 1.2 and 6.8. At pH 7.4, both loaded samples gave a similar dissolution trend with\ncomplete degradation achieved after 10ââ?¬â??11 h. Following five-month storage, 57.8% reduction in\nviability was observed....
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