Current Issue : January - March Volume : 2018 Issue Number : 1 Articles : 7 Articles
Purpose. This meta-analysis was conducted to compare the intraoperative and postoperative outcomes of bimanual microincision\ncataract surgery (B-MICS) and coaxial microincision cataract surgery (C-MICS). Methods. Three databases were searched for\npapers that compared B-MICS and C-MICS from inception to June 2016. The following intraoperative and postoperative\noutcomes were included in the final meta-analysis: ultrasound time (UST), effective phacoemulsification time (EPT), balanced\nsalt solution use (BSS use), mean surgery time, best-corrected visual acuity (BCVA), central corneal thickness (CCT), and\nincreased CCT. Results. There were no statistically significant differences in mean surgery time, UST, BSS use, BCVA, CCT, or\nincreased CCT (one subgroup at postoperative day 7-8 and another subgroup at postoperative day 30). However, there was less\nEPT needed during surgery (p < 0 01) and lower levels of increased CCT at postoperative day 1 (p = 0 02) in the B-MICS group\ncompared with the C-MICS group. Conclusions. The EPT was shorter and increased CCT was less at postoperative day 1 in the\nB-MICS group. There were no statistically significant differences in other intraoperative and postoperative outcomes between\nthe B-MICS group and the C-MICS group. B-MICS is an efficient and safe cataract surgery procedure....
Purpose: To compare intraocular pressure (IOP)-lowering efficacy and safety\nof travoprost 0.004% and travoprost 0.004% and beta-blocker 0.5% fixed\ncombination ophthalmic solution in patients with open-angle glaucoma and\nocular hypertension. Methods: In this prospective, multicentre clinical trial,\n62 patients received travoprost 0.004% (n = 31) or travoprost 0.004% and beta-\nblocker 0.5% fixed combination (n = 31). Efficacy and safety were compared\nacross treatment groups over 2 years. IOP reduction and adverse events\nwere examined at 3, 6, 12 and 24 months for each group. Results: Mean IOP\nat the first visit in the travoprost 0.004% group was 26.4 (SD �± 2.1), and travoprost\n0.004%/timolol 0.5% group was 26.3 (SD �± 2.1). Mean IOP after 24\nmonths in the travoprost 0.004% group was 20.5 (SD �± 1.5) and travoprost\n0.004%/timolol 0.5% group was 18.5 (SD �± 1.5). There were statistically significant\ndifferences in IOP in both eyes after third visit (after 1 year) and\nfourth visit (after 2 years). Conclusion: After 2 year of treatment, travoprost\n0.004%/timolol 0.5% produced clinically relevant IOP reductions in patients\nwith open-angle glaucoma or ocular hypertension that were greater than those\nproduced by travoprost 0.004% alone....
Background: To investigate the distribution of the height, weight and body mass index (BMI) of children with\ncongenital cataracts (CC) before surgical treatment.\nMethods: This prospective study included children with CC ââ?°Â¤14 years of age presenting at the Zhongshan\nOphthalmic Center from Jan. 2013 to Aug. 2016. The height, weight, and BMI measurements of all participating\nchildren were obtained and compared with the World Health Organization Child Growth Reference (WHO Reference),\nmatched by age and gender. The presence of a family history of CC or complicated systemic diseases as well as\nparental education levels and family income were also recorded.\nResults: In total, 595 children with CC were included. The mean age was 52.75 Ã?± 33.99 months, and 34.29%\n(204/595) of them were unilateral cases. Among all of the children, 6.72% (40/595) of cases were complicated\nby systemic diseases. More than 1/5 (21.01%, 125/595) of the children had a family history of CC and exhibited\nbilateral involvement. Less than 1/4 (23.2) of the mothers were highly educated, and more than half of the\nfamilies had a family income below the city average. Height, weight, and BMI measurements of most children\nwith CC were within the normal ranges (Ã?±95% CI of the WHO Reference). Compared to the WHO Reference,\nboth girls and boys aged 2ââ?¬â??5 years revealed shorter heights, and the girls aged 5ââ?¬â??14 years exhibited a shorter\nheight, lower body weight and lower BMI. The heights of the children with CC and systemic diseases were also\nshorter than the WHO Reference. The children with CC who had a family history of disease had shorter heights\nand lower BMIs than children with CC but no family history, and the measurements of both groups were lower\nthan the WHO Reference values.\nConclusions: The height, weight and BMI of most of the children with CC in this study were within the normal ranges\nof the WHO Reference. However, the children with CC and concomitant systemic diseases and those with a family\nhistory of CC had shorter heights and lower BMIs. This information aids in our understanding of the physical\ndevelopment of children with CC....
Background: The effects of preservatives of antiglaucoma medications on corneal surface and tear function have\nbeen widely shown in literature; it�s not the same as regards the active compounds themselves. The purpose of our\nstudy was to compare Ocular Surface Disease (OSD) signs and symptoms of Tafluprost 0.0015% versus preservative\nfree (PF) Timolol 0.1% eyedrops in ocular hypertensive (OH) and in primary open-angle glaucoma (POAG) patients.\nMethods: A cross-sectional study included patients in monotherapy for at least 36 months with Tafluprost 0.0015%\n(27) or PF Timolol 0.1% (24) and 20 healthy age and sex-matched volunteers. All subjects underwent clinical tests\n(Schirmer I and break-up time), in vivo confocal microscopy (IVCM) and were surveyed using Ocular Surface Disease\nIndex (OSDI) and Glaucoma Symptoms Scale (GSS) questionnaires. The groups were compared with ANOVA,\nKruskal-Wallis test, t-test, Mann-Whitney test and Bonferroni�s adjustment of p-values.\nResults: No significant differences were found in questionnaires scores, clinical tests, IVCM variables between\ntherapy groups. Tafluprost 0.0015% group showed significantly higher OSDI score, basal epithelial cells density,\nstromal reflectivity, sub-basal nerves tortuosity (p = 0.0000, 0.037, 0.006, 0.0000) and less GSS score, number of\nsub-basal nerves (p = 0.0000, 0.037) than controls but similar clinical tests results (p > 0.05). PF Timolol group\nhad significantly higher OSDI score, basal epithelial cells density, stromal reflectivity and sub-basal nerve tortuosity (p = 0.\n000, 0.014, 0.008, 0.002), less GSS score, BUT and number of sub-basal nerves (p = 0.0000, 0.026, 0.003) than controls.\nConclusions: Compared to PF Timolol 0.1%, Tafluprost 0.0015% showed similar safety with regards to tear function and\ncorneal status and a similar tolerability profile. Both therapy groups show some alterations in corneal microstructure but\nno side effects on tear function except for an increased tear instability in PF Timolol 0.1% group. Ophtalmologists should\nbe aware that even PF formulations may lead to a mild ocular surface impairment...
Aim. To report outcomes of pars plana vitrectomy (PPV) in pediatric retinal detachment (RD) with proliferative vitreoretinopathy\n(PVR), complications, factors influencing the final anatomical and functional results. Methods. Retrospective consecutive case\nseries of 14 eyes. Average postoperative follow-up period was 34 months. Results. Mean age of patients was 10 years; eleven\npatients (79%) were males. The most common etiology was trauma (57%), the secondââ?¬â?myopia (36%) and one case of uveitis\n(7%). At the day of presentation, the best-corrected visual acuity (BCVA) was worse than hand motion (50%); macula was\ndetached in 86% of cases. Simultaneous PPV and phacoemulsification with intraocular lens (IOL) implantation were performed\nin 12 cases (86%). The most common endotamponade during PPV was silicone oil (93%). Anatomic reattachment was\naccomplished in 86% of cases. Final BCVA was equal or better than 0.1 in 50% of patients. The postoperative complications\nwere found in 5 eyes (36%). Conclusion. Complete PPV was allowed for anatomically reattached retina and preserved vision\nin pediatric complex RD with PVR. However, visual outcomes were not satisfactory. Preserving vision in children with RD is\nof great importance for their future motor and intellectual development. This trial is registered with ClinicalTrials.gov\nIdentifier: NCT03208205....
Purpose. The aim of this study was twofold: first, to evaluate the predisposing factors for occurrence of malignant glaucoma and\nsecond, to compare frequency of malignant glaucoma depending on the type of primary glaucoma surgery. Methods.\nRetrospective analysis was performed in 1689 consecutive patients who underwent glaucoma surgery alone or combined with\nphacoemulsification. Data collected included the type of surgery, width of the filtration angle, presence or absence of malignant\nglaucoma in the postoperative period, and time from the primary surgery to malignant glaucoma occurrence. Results. Malignant\nglaucoma occurred in 22 eyes that amounted to 1.3% of cases among all surgery performed. Mean time from glaucoma surgery\nto malignant glaucoma occurrence was 61.4 �± 190.5 days. Among patients with penetrating surgery, malignant glaucoma\noccurred in 2.3% of patients, whereas after nonpenetrating operations, such complication was not found (p = 0 00004).\nMalignant glaucoma occurred more often in patients with shallow iridocorneal angle (p = 0 0013). Conclusions. The risk of\nmalignant glaucoma development is associated with penetrating characteristic of glaucoma surgery, after which this\ncomplication appears and its occurrence is higher in eyes with shallow iridocorneal angle. The risk of malignant glaucoma after\ntrabeculectomy compared to iridencleisis as well as after phacotrabeculectomy compared to phacoiridencleisis is equivalent....
Background/Aims. To investigate the patterns of retinal ganglion cell damage at different stages of glaucoma, using the\ncircumpapillary retinal nerve fiber layer (RNFL) and macula ganglion cell-inner plexiform layer (GCIPL) thicknesses.\nMethods. In 296 eyes of 296 glaucoma patients and 55 eyes of 55 healthy controls, the correlations of mean deviation (MD) with\nthe superior and inferior quadrant RNFL/GCIPL thickness (defined as the average of three superior and inferior sectors, resp.)\nwere analyzed. Results. In early to moderate glaucoma, most of the RNFL/GCIPL thicknesses had significant positive\ncorrelations with the MD. In advanced glaucoma, the superior GCIPL thickness showed the highest correlation with MD\n(r = 0 495), followed by the superior RNFL (r = 0 452) (all; P < 0 05). The correlation coefficient of the inferior RNFL\nthickness with MD (r < 0 471) was significantly stronger in early to moderate glaucoma compared to that in advanced glaucoma\n(r = 0 192; P < 0 001). In contrast, the correlations of the superior GCIPL thickness with MD (r = 0 452) in advanced glaucoma\nwas significantly stronger compared to that in early to moderate glaucoma (r = 0 159; P < 0 001). Conclusions. The most\npreserved region in advanced glaucoma appears to be the superior macular GCIPL, whereas the most vulnerable region for\ninitial glaucoma is the inferior RNFL around the optic disc....
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