Current Issue : October - December Volume : 2018 Issue Number : 4 Articles : 6 Articles
Background. Diarrhea is one of the leading causes of preventable death in developing countries and mainly affects children and\ninfants. It has been reported that the leaf of Justicia schimperiana is used as an antidiarrheal agent in Libo Kemekem district,\nnorthwest Ethiopia. Method. The 80% methanolic leaf extract of J. schimperiana was evaluated for its activity against castor oilinduced\ndiarrhea, enteropooling, and gastrointestinal motility in mice. Results. Significant reduction (...
Over the last few decades, Rumex species have been recognized as a promising source of new compounds with numerous\npharmacological activities. Therefore, the antioxidant activity of Rumex tingitanus (R. tingitanus) leaves extracts was evaluated\nin vitro and then confirmed in vivo as well as the antidepressant-like and toxicological effects of the extracts. The ethyl acetate\nfraction (Rt EtOAcF) followed by hydroalcoholic extract (Rt EtOH-H2O) showed a remarkable in vitro antioxidant activity. The\nhydroalcoholic extract (Rt EtOH-H2O) showed significant hepatoprotective activity against carbon tetrachloride- (CCl4-) induced\nliver toxicity which is seen frominhibition of the malondialdehyde (MDA) accumulation and enhancement of the liver antioxidant\nenzymes activities. The Rt EtOH-H2O and Rt EtOAcF extracts were able to reduce the immobility time in mice and then elicited\na significant antidepressant-like effect. The ethyl acetate fraction (Rt EtOAcF) was purified and resulted in the identification of a\nnew antioxidant component called 4...
Discovery and identification of three bioactive compounds affecting endothelial function in\nGinkgo biloba Extract (GBE) based on chromatogram-bioactivity correlation analysis. Three portions\nwere separated from GBE via D101 macroporous resin and then re-combined to prepare nine GBE\nsamples. 21 compounds in GBE samples were identified through UFLC-DAD-Q-TOF-MS/MS.\nCorrelation analysis between compounds differences and endothelin-1 (ET-1) in vivo in nine GBE\nsamples was conducted. The analysis results indicated that three bioactive compounds had\nclose relevance to ET-1: Kaempferol-3-O-�±-L-glucoside, 3-O-{2-O-{6-O-[P-OH-trans-cinnamoyl]-\n�²-D-glucosyl}-�±-rhamnosyl} Quercetin isomers, and 3-O-{2-O-{6-O-[P-OH-trans-cinnamoyl]-\n�²-D-glucosyl}-�±-rhamnosyl} Kaempferide. The discovery of bioactive compounds could provide\nreferences for the quality control and novel pharmaceuticals development of GRE. The present work\nproposes a feasible chromatogram-bioactivity correlation based approach to discover the compounds\nand define their bioactivities for the complex multi-component systems....
Cognitive dysfunction is a major health problem in 21st century, one of the most functionally devastating aspects of many neuropsychiatric disorders and neurodegenerative disorders. Gmelina arborea Roxb. belongs to the family Verbinaceae. It is found in part of India, Western Ghats and from foot of North-West Himalaya to Chittagong and throughout Deccan Peninsula. This plant is planted in gardens and also as an avenue tree. The aim of present study was to study the nootropic effect of chloroform extract of Gmelina arborea (CEGA) and hydro-alcoholic extract of Gmelina arborea (HAEGA) by using various animal models. The models used for the study of nootropic activity of CEGA and HAEGA were step down passive avoidance, sodium nitrite induced amnesia, elevated plus maze in mice and conditioned avoidance response in rat. The CEGA (500 mg/kg) and HAEGA (500 mg/kg) was suspended in distilled water and administered orally to mice and rat. Piracetam was administered orally as a standard drug. Control animals receive equivalent volume of distilled water. Scopolamine (0.4 mg/kg) and sodium nitrate (35 mg/kg) significantly decreased the step down latency (SDL) compare to control group in learning and memory trials. On treatment with CEGA (500 mg/kg) and HAEGA (500 mg/kg) significantly reversed scopolamine and sodium nitrate induced spatial memory impairment as compared to negative control group. In conditioned avoidance response, CEGA (500 mg/kg) and HAEGA (500 mg/kg) significantly reduced time taken by the rat to climb the pole while in the elevated plus-maze test, mice treated with CEGA (500 mg/kg) and HAEGA (500 mg/kg) significantly reduced transfer latency (TL). The present study suggests that chloroform extract and hydro-alcoholic extract of Gmelina arborea shows statistically significant nootropics activity....
Since ancient times, mankind all over the world mainly depended upon the plant kingdom to meet their all needs of medicines, for alleviating ailments. The present work carried out as an ethnobotanical approach based on the historical medicinal values of shikakai containing saponin glycosides. The results of preliminary phytochemical tests on aqueous extract of seed kernels showed that the presence of saponins, steroids, flavonoids, tannins, proteins and carbohydrates. The antibacterial activity of aqueous extract of seed kernels of the Acacia concinna by cup plate method has maximum activity against gram positive organism, Bacillus subtilis followed by the gram negative organism Proteus vulgaris. The staphylococcus aureus and E. coli organisms showed nearly equal inhibition. The extract has least activity on Micrococcus luteus. The inhibitory actions on both gram positive and negative organisms due to presence of multiple active plant constituents present in the extract along with inert constituents. The aqueous extract of seed kernels showed paralysis and death of earth worms more than the standard drug piperazine citrate at the tested lowest concentration of 10 mg/ml, it might be due to presence of remarkable proved anthelmintics, saponins, tannins and flavonoids present in the extract....
Extracts of aerial part of Euphorbia characias were examined to check potential inhibitors for three selected enzymes involved\nin several metabolic disorders. Water and ethanol extracts from leaves and flowers showed in vitro inhibitory activity toward ...
Loading....