Current Issue : July - September Volume : 2018 Issue Number : 3 Articles : 5 Articles
Trabectedin is a synthetic antineoplastic drug, binding to the minor groove of\nDNA and affecting DNA repair pathways, resulting in G2-M cell cycle arrest\nand apoptosis. Trabectedin has demonstrated high efficacy against various\nsoft tissue sarcomas. However, its extravasation causes serious complications,\nsuch as tissue necrosis and a delay in the treatment of underlying diseases.\nMethods: We experienced a rare case in which trabectedin extravasation\ncaused severe pectoralis major muscle necrosis. A 45-year-old man with multiple\nlung metastases of follicular dendritic cell sarcoma received 2.15 mg of\ntrabectedin totally through a central venous access device (CVAD) system in\nthe right precordium. Computed tomography showed extensive turbidity of\nsubcutaneous fatty tissue and swelling of the pectoralis major muscle to the\nupper margin of the liver, and the creatine kinase level was elevated to 759\nU/L (reference value from 54 to 286). We performed surgical debridement\ntwice, and the CVAD was concomitantly removed; thereafter, the skin defect\nwas reconstructed with a split skin mesh graft. Results: Histopathology\nshowed extreme degeneration of striated muscle and fatty tissue. Unfortunately,\ndisability of the right arm abducens persisted after treatment because\nof debridement around the right humerus muscle. Discussion: Several reports\nhave described cases of the extravasation of trabectedin. A few have\nmentioned severe muscular degeneration similar to that shown in the present\ncase. Because trabectedin is a strong vesicant cytotoxic agent, it is principally\nadministered through a CVAD rather than peripheral vessels and is continued\nduring the nighttime; this can lead to a delay in patients or attending\ndoctors noticing any extravasation. We need to spread appropriate knowledge\nof this drug and make an effort to prevent severe complications like in the present case....
Background. Malignant melanoma is among the fastest increasing malignancies in many countries. With the help of new tools,\nsuch as teledermoscopy referrals between primary healthcare and dermatology clinics, the diagnosis of these patients could\nbe made more efficient. The introduction of a high-quality smartphone with a built-in digital camera may make the early\ndetectionmore convenient.This study presents novel directions for early detection ofmalignantmelanoma based on a smartphone\napplication. Objectives and Methods. In this study, we concentrate on a precise description of a complex infrastructure of a fully\nautomated computer-aided diagnostic system for early detection of malignant melanoma. The framework has been customized\nfor a dermoscope that is customized to attach to the smartphone to be able to carry out mobile teledermoscopy. The application\nrequirements, architecture, and computational methods as well as behavioral and dynamic aspects have been presented in this\npaper. Conclusion. This paper presents a broad application architecture, which can be easily customized for rapid deployment of\na sophisticated health application. Mobile teledermoscopy is a new horizon that might become in the future the basis of the early\ndetection of pigmented skin lesions as a screening tool for primary care doctors and inexperienced dermatologists....
Several herbal remedies have been used as topical agents to cure burn wound, one of the most common injuries in worldwide. In\nthis study, we investigated the potential use of Cleistocalyx operculatus essential oil to treat the burn wound.We identified a total of\n13 bioactive compounds of essential oil, several of which exhibited the anti-inflammatory and antimicrobial activities. Furthermore,\nthe essential oil showed the antibacterial effect against S. aureus but not with P. aeruginosa. The supportive effect of essential oil\non burn wound healing process also has been proven. Among three groups of mice, wound contraction rate of essential oil treated\ngroup (100%) was significantly higher than tamanu oil treated (79%) and control mice (71%) after 20 days (0.22 �± 0.03 versus\n0.31 �± 0.02 cm2, resp., ...
It was tried to microencapsulate camellia oil using heterocoagulation between\nfatty acid dissolved in camellia oil and chitosan dissolved in the continuous\nwater phase. Oleic acid as a fatty acid was dissolved in camellia oil in order to\ncertainly form the microcapsule shell made from oleic acid and chitosan. The\nmicrocapsules were observed with optical microscope and characterized about\nthe diameters, Ã?¶ -potential, FTIR analysis and adhesion feature on human hair.\nMicroca psules with the mean diameter in the range from ca. 1.5 Ã?¼m to 4.5 Ã?¼m\ncould be prepared with the preparation method presented in this study. The\noil droplets of camellia oil charged negatively to be âË?â??54.6 mV and the microcapsules\ncharged positively to be 59.6 mV. The microcapsules adhered well on\nthe negatively charged human hair and were kept stably before and after drying\nat room temperature for 24 h and blowing....
We frequently encounter characteristic color variation including hypopigmentation,\nhyperpigmentation, and erythema in extramammary Paget�s disease\n(EMPD) lesions. Owing to unclear hypopigmentation, the lesional border\nof EMPD can be poorly defined and it is likely insufficient to perform its\ncomplete resection. Although the existence of Toker�s cells and lack of lesional\nbFGF production have been reported to cause hypopigmentation inside of\nEMPD lesions, exact mechanisms of hypopigmentation in EMPD are not fully\nexplored. We experienced three EMPD patients with obviously hypopigmented\nEMPD macules and histopathologically confirmed a reduced number\nof melanocytes on the hypopigmented macules and their loss on the erythematous\nplaques or nodules. An ultrastructural analysis on the hypopigmented\nlesions revealed disturbance of melanosome maturation and melanosome\ntransfer to the adherent Pagets� cell on the basal layer. No Paget�s cells even\nadhered to remaining melanocytes with dendrites contained matured melanosome\nand a few number of matured melanosome complexes were observed\nin basal keratinocytes. In the present study, we hypothesize that severe disturbance\nof not only melanogenesis but also melanosome transfer to surrounding\nPaget�s cells and basal keratinocytes may cause characteristic hypopigmentation\nin EMPD. Future bioanalysis would reveal molecular mechanisms\nfor hypopigmentation in EMPD....
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