Current Issue : October - December Volume : 2018 Issue Number : 4 Articles : 5 Articles
Objective. The outcomes of biatrial ablation (BA) and isolated left atrial ablation (LA) in atrial fibrillation remain inconclusive.\nIn this meta-analysis, we assess the currently available evidence to compare outcomes between BA and LA. Methods. Electronic\nsearches were performed from database inception to December 2016, and relevant studies were accessed. Odds ratios and weight\nmean differences with 95% confidence intervals are reported. Twenty-one studies comprising 3609 patients were included in the\npresent meta-analysis. Results. The prevalence of sinus rhythm in the BA cohort was similar to that in the LA cohort at discharge,\nat 12 months, and after more than 1 year of follow-up. However, at 6 months, the prevalence of sinus rhythm was higher in the BA\ncohort than in the LA cohort.The rate of permanent pacemaker implantation was higher in the BA cohort than in the LA cohort.\nHowever, 30-day and late mortality and neurological events were similar between the BA and LA groups. Conclusion. There was\nno significant difference in the rate of restored sinus rhythm, the risk of death, and cerebrovascular events between BA and LA, but\nBA had a higher rate of permanent pacemaker implantation....
Breijo�s electrocardiographic model is becoming better known to cardiologists\nevery day. The decrease in the PR interval, together with the decrease of the\nQTc interval in the same individual, is the main and only feature of the same\nindividual. It can often go unnoticed, but many problems could be avoided if\nit was previously diagnosed, including sudden death....
Objective: Making the interest of using immunohistochemistry clear in addition\nto histological test in the diagnosis of lymphomas. Methods: This is a retrospective\nstudy from January 2011 to June 2013 involving 18 cases of lymphomas\ncollected in the teaching hospitals of Treichville and Yopougon.\nResults: 1) 38.88% diagnosis of LMNH B large-cell in histology against\n38.88% LDGCB with IHC. 2) 11.11% diagnosis of LMNH small cell in histology\nagainst 11.11% with IHC. 3) 5.55% diagnosis of T lymphoma in histology\nagainst 27.77% diagnosis of T lymphoma with IHC. 4) 5.55% diagnosis of follicular\nlymphoma in histology against 11.11% diagnosis of LF with IHC. 5)\n11.11% diagnosis of Burkitt lymphoma in histology against 5.55% diagnosis of\nLB with IHC. 6) 5.55% diagnosis of medullary hypoplasia in histology against\n5.55% diagnosis of Hodgkin�s disease. Our results confirm the contribution of\nimmunohistochemistry in the diagnosis of lymphomas in addition to histological\ntest. This is striking, especially as there is 27.77% of T lymphoma with\nimmunohistochemistry against only 5.55% with histology....
Background: Acute heart failure timely and effective diagnosis and treatment\ndirectly affects the prognosis of patients, so early diagnosis of acute heart failure\ntreatment is very important. The current diagnosis of acute heart failure\nhas yet to be further improved. To investigate the relationship between plasma\nlevels of Galectin-3 and NT-proBNP in cardiac structure and function in patients\nwith acute heart failure (AHF) Early detection of failure. Methods: The\nclinical data of 86 patients with acute heart failure in our hospital were analyzed\nand followed up. Twenty-six healthy subjects with normal cardiac function\nwere used as control group. The plasma Galectin-3 and NT-proBNP levels\nwere compared between the two groups to observe the value of plasma\nGalectin-3 combined with NT-proBNP in the diagnosis of acute heart failure.\nResults: There was no significant difference in the level of Galectin-3 and\nNT-proBNP between heart function group II and control group, and the levels\nof cardiac function III and IVG plasma Galectin-3 and NT-proBNP were\nsignificantly higher in patients with heart failure Compared with the healthy\ncontrol group, the patients� LVEF decreased and their cardiac function increased.\nThe levels of plasma Galectin-3 and NT-proBNP increased significantly\n(P < 0.01). Multivariate Logistic regression analysis demonstrated that\nplasma levels of Galectin-3 and NT-proBNP were independent of cardiac\nfunction. The area under the ROC curve for the combined detection of plasma\nGalectin-3 and NT-proBNP was greater than the area under the two alone\ntests. Conclusion: The combined detection of Galectin-3 and NT-proBNP has\nhigh sensitivity and specificity in the diagnosis of acute heart failure and can\nbe used as a new detection mode....
Bruton�s tyrosine kinase (BTK) is a critical terminal enzyme in the B-cell antigen receptor\n(BCR) pathway. BTK activation has been implicated in the pathogenesis of certain B-cell malignancies.\nTargeting this pathway has emerged as a novel target in B-cell malignancies, of which ibrutinib\nis the first-in-class agent. A few other BTK inhibitors (BTKi) are also under development (e.g.,\nacalabrutinib). While the predominant action of BTKi is the blockade of B-cell receptor pathway\nwithin malignant B-cells, increasing the knowledge of off-target effects as well as a potential\nrole for B-cells in proliferation of solid malignancies is expanding the indication of BTKi into\nnon-hematological malignancies. In addition to the expansion of the role of BTKi monotherapy,\ncombination therapy strategies utilizing ibrutinib with established regimens and combination with\nmodern immunotherapy compounds are being explored....
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