Current Issue : July - September Volume : 2019 Issue Number : 3 Articles : 5 Articles
Sustained-release olmesartan tablets (OLM) were prepared by the simple, direct\ncompression of composites of anionic sulfobutyl ether...............................
Lovastatin (LOV) is a drug used to treat hypercholesterolemia. Recent studies have\nidentified its antioxidant effects and potential use in the treatment of some types of cancer. However,\nthe low bioavailability related to its poor water solubility limits its use in solid oral dosage forms.\nTherefore, to improve the solubility of LOV three eutectic systems of LOV with the carboxylic\nacids benzoic (BEN), salicylic (SAL) and cinnamic (CIN) were obtained. Both binary phase and\nTammann diagrams were constructed using differential scanning calorimetry (DSC) data of mixtures\nprepared from 0.1 to 1.0 molar ratios. Binary mixtures and eutectics were prepared by liquid-assisted\ngrinding. The eutectics were further characterized by DSC and powder X-ray diffraction (PXRD),\nFourier-transform infrared spectroscopy (FT-IR) and scanning electron microscopy (SEM). The\nLOV-BEN, LOV-SAL and LOV-CIN system formed a eutectic at an LOV mole fraction of 0.19,\n0.60 and 0.14, respectively. The systems exhibited improvements in LOV solubility, becoming more\nsoluble by five-fold in the LOV-SAL system and approximately four-fold in the other two systems.\nConsidering that the solubility enhancements and the carboxylic acids used are generally recognized\nas safe by the U.S. Food and Drug Administration (FDA), the LOV eutectic systems are promising\nmaterials to be used in a solubility enhancement strategy for pharmaceutical product formulation....
Mesalamine an anti-inflammatory drug, which degrades in acidic environment. Hence protection of drug is done by coating the drug with retardant coating polymers. The aim and objective of the present study was to prepare press coated tablets of mesalamine by press coating technique. Core tablets were prepared by direct compression method and evaluated for their physicochemical properties. Formulations for press coating method were selected based on physicochemical properties and in-vitro drug release characteristics. Press coated tablets were formulated by using different combinations of ethyl cellulose, HPMC E15 and cellulose acetate phthalate as a coating layer. Among the various formulations, F3 formulation containing ethyl cellulose: HPMC E15 (10:90) and F4 formulation containing ethyl cellulose: cellulose acetate phthalate (20:80) were optimized based on their better drug release within 8 hrs. SEM studies of press coated tablets showed that the surface of core tablet is uniformly coated by press coating. Stability studies are conducted for optimized formulation and results showed that the formulations were stable. As a result, press coated tablets developed in this study delivered mesalamine in the intestine and protected the drug from degradation in stomach....
The discovery of a new pharmacological application of berberine hydrochloride (BH) made\nit more clinically valuable. However, the further development of BH was hampered by its short\nhalf-life and side effects after intravenous injection. To overcome these problems, a novel BH delivery\nsystem was developed using natural red blood cell membrane-camouflaged BH-loaded gelatin\nnanoparticles (RBGPs) to reduce the toxicity associated with injections and achieve sustained release.\nThe size of the RBGPs was......................
The advent and growth of resistance phenomena to antibiotics has reached critical levels,\ninvalidating the action of a majority of antibiotic drugs currently used in the clinical field. Several\ninnovative techniques, such as the nanotechnology, can be applied for creating innovative drug\ndelivery systems designed to modify drug release itself and/or drug administration route;\nmoreover, they have proved suitable for overcoming the phenomenon of antibiotic resistance.\nElectrospun nanofibers, due to their useful structural properties, are showing promising results as\nantibiotic release devices for preventing bacteria biofilm formation after surgical operation and for\nlimiting resistance phenomena. In this work gentamicin sulfate (GS) was loaded into polylactide-copolycaprolactone\n(PLA-PCL) electrospun nanofibers; quantification and in vitro drug release\nprofiles in static and dynamic conditions were investigated; GS kinetic release from nanofibers was\nstudied using mathematical models. A preliminary microbiological test was carried out towards\nStaphylococcus aureus and Escherichia coli bacteria....
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