Current Issue : April - June Volume : 2019 Issue Number : 2 Articles : 5 Articles
The development of effective forms to incorporate poorly soluble drugs into delivery\nsystems remains a problem. Thus, it is important to find alternatives such as finding excipients\nthat increase drug solubility. Ionic liquids (ILs), particularly choline-based ILs, have been studied\nas solubility enhancers in drug delivery systems. Nonetheless, to acknowledge this property as a\nfunctionality, it needs to be proven at non-toxic concentrations. Hence, herein two choline-amino\nacid ILs were studied as functional excipients by evaluating their influence on the solubility of the\npoorly water-soluble ferulic acid and rutin, while considering their safety. The solubility of the drugs\nwas always higher in the presence of the ILs than in water. Ionic liquids did not affect the radical\nscavenging activity of the drugs or the cell viability. Moreover, stable oil-in-water (O/W) emulsions\nwere prepared containing each drug and the ILs, allowing a significantly higher drug loading.\nGlobally, our results suggest that choline-based ILs may act as green functional excipients, since at\nnon-toxic concentrations they considerably improve drug solubility/loading, without influencing the\nantioxidant activity of the drugs, the cell viability, or the stability of the formulations....
Nail delivery has interest for local treatment of nail diseases. Nevertheless, the low\npermeability of drugs in the nail plaque precludes the efficacy of local treatments. The use of\npenetration enhancers can increase drug permeability and improve the efficacy of the treatment of nail\npathologies. In this work, different chemical substances have been evaluated as potential penetration\nenhancers. With this aim, the effect of different substances such as sodium lauryl sulfate (SLS),\npolyethylene glycol 300 (PEG 300), carbocysteine, N-acetylcysteine, lactic acid, potassium phosphate,...........
Amphotericin B is a low soluble broad-spectrum antifungal agent. Cyclodextrins can\nbe added to amphotericin formulations to enhance both their solubility and antifungal properties.\nSemisolid amphotericin formulations containing gamma cyclodextrin (AGCD) were prepared and\ncompared with two reference formulationsâ??one of them without any solubility enhancer (A)\nand the other with DMSO (ADMSO). Rheological, the permeability through hairless mouse skin\nand antifungal characteristics of the different formulations were evaluated. All three semisolid\nformulations show low thixotropy characteristics. ADMSO was the formulation with the least\nconsistency, lowest viscosity, and greatest extensibility. The AGCD formulation had the opposite\nbehavior and had both the greatest consistency and viscosity and the lowest extensibility. The lowest\npermeability was obtained with the reference A formulation while both AGCD and ADMSO had a\nsimilar permeability enhancement. According to the antimicrobial in vitro efficacy trials, the AGCD\nformulation showed 45â??60% more activity than the reference A formulation. It can be concluded thatâ?¦â?¦â?¦....
This study is carried out on polysaccharide-based hydrogel extracted from the seeds of Ocimum basilicum L. for its evaluation\nas a superabsorbent and stimuli responsive biomaterial for sustained release drug delivery system. O. basilicum (Syn: Basil) seed\nhydrogel (BSH) expressed high swelling capacity at pH 6.8 and 7.4 and deionized water.Highly reversible on-off switching (swellingdeswelling)\nbehavior of BSHwas ascertained in deionized water and ethanol, pH 7.4 and 1.2, and deionized water and normal saline.\nScanning electron microscopy (SEM) of BSHhas revealed macroporous structure of BSHhaving average pore size of.................
Onychomycosis affects about 15% of the population. This disease causes physical\nand psychosocial discomfort to infected patients. Topical treatment (creams, solutions, gels,\ncolloidal carriers, and nail lacquers) is usually the most commonly required due to the high toxicity\nof oral drugs. Currently, the most common topical formulations (creams and lotions) present a low\ndrug delivery to the nail infection. Nail lacquers appear to increase drug delivery and simultaneously\nimprove the effectiveness of treatment with increased patient compliance. These formulations leave a\npolymer film on the nail plate after solvent evaporation. The duration of the film residence in the nail\nconstitutes an important property of nail lacquer formulation. In this study, a polyurethane polymer\nwas used to delivery antifungals drugs, such as terbinafine hydrochloride (TH) and ciclopirox olamine\n(CPX) and the influence of its concentration on the properties of nail lacquer formulations was\nassessed. The nail lacquer containing the lowest polymer concentration (10%) was the most effective\nregarding the in vitro release, permeation, and antifungal activity. It has also been demonstrated that\nthe application of PU-based nail lacquer improves the nail plate, making it smooth and uniform and\nreduces the porosity contributing to the greater effectiveness of these vehicles. To conclude, the use\nof polyurethane in nail formulations is promising for nail therapeutics....
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